potassium;trifluoro(hept-1-enyl)boranuide | 847153-80-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 硼酸衍生物
• 英文名称: potassium;trifluoro(hept-1-enyl)boranuide
• CAS: 847153-80-4
• 化学式: C₇H₁₃BF₃*K
• 分子量: 204.085
• InChiKey: NTVXNUXMYHANGQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.51
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  potassium;trifluoro(hept-1-enyl)boranuide 在 palladium diacetate 、 silver(l) oxide 作用下， 以 二甲基亚砜 为溶剂， 反应 7.0h， 以42%的产率得到十四碳-6,8-二烯
  参考文献：
  名称：

  Palladium-catalyzed oxidative homocoupling of potassium alkenyltrifluoroborates: synthesis of symmetrical 1,3-dienes

  摘要：

  Herein, we describe a convenient method for the synthesis of symmetrical 1,3-dienes employing an oxidative palladium-catalyzed homocoupling of potassium alkenyltrifluoroborates providing products in good yields relative to existing methodologies. This is the first report of a cross-dimerization of potassium alkenyltrifluoroborates. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.04.127
• 作为产物：
  描述：

  1-庚炔 在 儿萘酚硼烷 、 potassium hydrogen difluoride 作用下， 以 水 为溶剂， 生成 potassium;trifluoro(hept-1-enyl)boranuide
  参考文献：
  名称：

  Palladium-catalyzed oxidative homocoupling of potassium alkenyltrifluoroborates: synthesis of symmetrical 1,3-dienes

  摘要：

  Herein, we describe a convenient method for the synthesis of symmetrical 1,3-dienes employing an oxidative palladium-catalyzed homocoupling of potassium alkenyltrifluoroborates providing products in good yields relative to existing methodologies. This is the first report of a cross-dimerization of potassium alkenyltrifluoroborates. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.04.127

文献信息

• Iron trichloride promoted hydrolysis of potassium organotrifluoroborates
  作者：David W. Blevins、Min-Liang Yao、Li Yong、George W. Kabalka

  DOI：10.1016/j.tetlet.2011.09.140

  日期：2011.12

  In the presence of iron trichloride, the hydrolysis of potassium organotrifluoroborates occurs smoothly at room temperature to afford the corresponding organoboronic acids in good to excellent yields. The hydrolysis is effective for aryltrifluoroborates as well as alkenyl- and alkyl-trifluoroborates.

  在三氯化铁的存在下，有机三氟硼酸钾的水解在室温下平稳进行，以良好或优异的产率提供相应的有机硼酸。水解对于芳基三氟硼酸盐以及烯基-和烷基三氟硼酸盐是有效的。
• Stereochemistry–activity relationship of orally active tetralin S1P agonist prodrugs
  作者：Bin Ma、Kevin M. Guckian、Edward Yin-Shiang Lin、Wen-Cherng Lee、Daniel Scott、Gnanasambandam Kumaravel、Timothy L. Macdonald、Kevin R. Lynch、Cheryl Black、Sowmya Chollate、Kyungmin Hahm、Gregg Hetu、Ping Jin、Yi Luo、Ellen Rohde、Anthony Rossomando、Robert Scannevin、Joy Wang、Chunhua Yang

  DOI：10.1016/j.bmcl.2010.02.006

  日期：2010.4

  Modifying FTY720, an immunosuppressant modulator, led to a new series of well phosphorylated tetralin analogs as potent S1P1 receptor agonists. The stereochemistry effect of tetralin ring was probed, and (-)(R)-2-amino-2-((S)-6-octyl-1,2,3,4-tetrahydronaphthalen-2-yl)propan-1-ol was identified as a good SphK2 substrate and potent S1P1 agonist with good oral bioavailability. (C) 2010 Elsevier Ltd. All rights reserved.