1,3,8-trihydroxy-6-amino-10H-anthracen-9-one | 918299-83-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 英文名称: 1,3,8-trihydroxy-6-amino-10H-anthracen-9-one
• 英文别名: 3-Amino-1,6,8-trihydroxyanthracen-9(10H)-one；3-amino-1,6,8-trihydroxy-10H-anthracen-9-one
• CAS: 918299-83-9
• 化学式: C₁₄H₁₁NO₄
• 分子量: 257.246
• InChiKey: TYUIDBMRQCYPSZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  19
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  104
• 氢给体数：
  4
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  1,3,8-trihydroxy-6-amino-10H-anthracen-9-one 、 乙酰氯 以 1,4-二氧六环 、 吡啶 为溶剂， 反应 1.0h， 以92%的产率得到1,3,8-trihydroxy-6-(acetylamino)-10H-anthracen-9-one
  参考文献：
  名称：

  A Route to Amino Functionalized Hypericin Derivatives and their Chemical and Photochemical Properties Pertaining to Photodynamic Therapy

  摘要：

  Syntheses of amino functionalized hypericin derivatives could be achieved starting from the recently prepared emodin derived 1,3,8-trimethoxy-6-amino-9,10-anthraquinone. Our strategies for the preparation of 10,11-didemethyl-10,11-diaminohypericin, 10,11-didemethyl-10,11-di(acetylamino) hypericin, and its hypericinoidic diazepine derivative include synthetical modifications on the levels of the anthraquinone, anthron, and the phenanthroperylenequinone system itself. The chemical as well as photochemical properties of these unique hypericin derivatives, which might constitute new photodynamic therapy agents, are reported.

  DOI：

  10.1007/s00706-005-0397-5
• 作为产物：
  描述：

  1,3,8-trimethoxy-6-amino-9,10-anthraquinone 在 氢溴酸 、 tin(ll) chloride 作用下， 以 溶剂黄146 为溶剂， 反应 0.5h， 以98%的产率得到1,3,8-trihydroxy-6-amino-10H-anthracen-9-one
  参考文献：
  名称：

  A Route to Amino Functionalized Hypericin Derivatives and their Chemical and Photochemical Properties Pertaining to Photodynamic Therapy

  摘要：

  Syntheses of amino functionalized hypericin derivatives could be achieved starting from the recently prepared emodin derived 1,3,8-trimethoxy-6-amino-9,10-anthraquinone. Our strategies for the preparation of 10,11-didemethyl-10,11-diaminohypericin, 10,11-didemethyl-10,11-di(acetylamino) hypericin, and its hypericinoidic diazepine derivative include synthetical modifications on the levels of the anthraquinone, anthron, and the phenanthroperylenequinone system itself. The chemical as well as photochemical properties of these unique hypericin derivatives, which might constitute new photodynamic therapy agents, are reported.

  DOI：

  10.1007/s00706-005-0397-5

文献信息

• A Route to Amino Functionalized Hypericin Derivatives and their Chemical and Photochemical Properties Pertaining to Photodynamic Therapy
  作者：Bernd Lackner、Klaus Bretterbauer、Clemens Schwarzinger、Heinz Falk

  DOI：10.1007/s00706-005-0397-5

  日期：2005.12

  Syntheses of amino functionalized hypericin derivatives could be achieved starting from the recently prepared emodin derived 1,3,8-trimethoxy-6-amino-9,10-anthraquinone. Our strategies for the preparation of 10,11-didemethyl-10,11-diaminohypericin, 10,11-didemethyl-10,11-di(acetylamino) hypericin, and its hypericinoidic diazepine derivative include synthetical modifications on the levels of the anthraquinone, anthron, and the phenanthroperylenequinone system itself. The chemical as well as photochemical properties of these unique hypericin derivatives, which might constitute new photodynamic therapy agents, are reported.