N-((4-oxo-4,5,7,8-tetrahydro-3H-pyrano[4,3-d]pyrimidin-2-yl)methaneyl)-2-(4-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)piperidin-1-yl)ethanamide | 1419952-47-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-((4-oxo-4,5,7,8-tetrahydro-3H-pyrano[4,3-d]pyrimidin-2-yl)methaneyl)-2-(4-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)piperidin-1-yl)ethanamide
• 英文别名: N-((4-oxo-4,5,7,8-tetrahydro-3H-pyrano[4,3-d]pyrimidin-2-yl)methyl)-2-(4-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)piperidin-1-yl)ethanamide；N-((4-Oxo-4,5,7,8-tetrahydro-3H-pyrano[4,3-d]pyrimidin-2-yl)methyl)-2-(4-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)piperidin-1-yl)acetamide；N-((4-Oxo-4,5,7,8-tetrahydro-3H-pyrano[4,3-d]pyrimidin-2-yl)methyl)-2-(4-(1,2,3,4-tetrahydroisoquinolin-2-carbonyl)piperidin-1-yl)acetamide；2-[4-(3,4-dihydro-1H-isoquinoline-2-carbonyl)piperidin-1-yl]-N-[(4-oxo-3,5,7,8-tetrahydropyrano[4,3-d]pyrimidin-2-yl)methyl]acetamide
• CAS: 1419952-47-8
• 化学式: C₂₅H₃₁N₅O₄
• 分子量: 465.552
• InChiKey: FDEXUIWWMRDSAV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  34
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  103
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  1-(2-oxo-2-((4-oxo-4,5,7,8-tetrahydro-3H-pyrano[4,3-d]pyrimidin-2-yl)methylamino)ethyl)piperidine-4-carboxylic acid 、 四氢异喹啉 、 生成 N-((4-oxo-4,5,7,8-tetrahydro-3H-pyrano[4,3-d]pyrimidin-2-yl)methaneyl)-2-(4-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)piperidin-1-yl)ethanamide
  参考文献：
  名称：

  2-piperidin-1-yl-acetamide compounds for use as tankyrase inhibitors

  摘要：

  本发明提供了式(I)的化合物，其中R1-R5和L如本文所定义。本发明还提供了包含式(I)化合物的药物组合物和制剂，以及将这些化合物用作坦克酶抑制剂和治疗Wnt信号和与坦克酶1和2信号相关的疾病的用途，包括但不限于癌症。

  公开号：

  US09181266B2

文献信息

• [EN] NOVEL 2-PIPERIDIN-1-YL-ACETAMIDE COMPOUNDS FOR USE AS TANKYRASE INHIBITORS<br/>[FR] NOUVEAUX COMPOSÉS 2-PIPERIDIN-1-YL-ACETAMIDE UTILISABLES EN TANT QU'INHIBITEURS DE TANKYRASE
  申请人：NOVARTIS AG

  公开号：WO2013012723A1

  公开（公告）日：2013-01-24

  The present invention provides for compounds of formula (I), wherein R1-R5 and L are defined herein. The present invention also provides for pharmaceutical compositions and combinations comprising a compound of formula (I) as well as for the use of such compounds as tankyrase inhibitors and in the treatment of Wnt signaling and tankyrase 1 and 2 signaling related disorders which include, but are not limited to, cancer.

  本发明提供了式(I)的化合物，其中R1-R5和L在此处定义。本发明还提供了包含式(I)化合物的药物组合物和组合物，以及将这些化合物用作坦基酶抑制剂以及用于治疗Wnt信号和坦基酶1和2信号相关疾病的用途，包括但不限于癌症。
• NOVEL 2-PIPERIDIN-1-YL-ACETAMIDE COMPOUNDS FOR USE AS TANKYRASE INHIBITORS
  申请人：Cheung Atwood Kim

  公开号：US20150025070A1

  公开（公告）日：2015-01-22

  The present invention provides for compounds of formula (I): wherein R 1 -R 5 and L are defined herein. The present invention also provides for pharmaceutical compositions and combinations comprising a compound of formula (I) as well as for the use of such compounds as tankyrase inhibitors and in the treatment of Wnt signaling and tankyrase 1 and 2 signaling related disorders which include, but are not limited to, cancer.

  本发明提供了公式（I）的化合物：其中R1-R5和L在此定义。本发明还提供了含有公式（I）化合物的药物组合物和组合物，以及将这些化合物用作坦克酶抑制剂和治疗与Wnt信号和坦克酶1和2信号相关的疾病的用途，包括但不限于癌症。
• US9181266B2
  申请人：——

  公开号：US9181266B2

  公开（公告）日：2015-11-10