2,6-dibromo-4-(methoxymethoxy)pyridine | 220616-69-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2,6-dibromo-4-(methoxymethoxy)pyridine
• CAS: 220616-69-3
• 化学式: C₇H₇Br₂NO₂
• 分子量: 296.946
• InChiKey: PIDUYYFYIVQKIX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  31.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2,6-dibromo-4-(methoxymethoxy)pyridine 在 bis-triphenylphosphine-palladium(II) chloride 、 tris(dibenzylideneacetone)dipalladium(0) chloroform complex 、 potassium fluoride 、 copper(l) iodide 、 水 、 二异丙胺 、 三对苯甲基膦 、 三氟乙酸 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 2.0h， 生成 2,6-bis(2-pyridylethynyl)-4(3H)-pyridone
  参考文献：
  名称：

  Rate enhancement of hexose sugar oxidation on an ethynylpyridine-functionalized Pt/Al2O3 catalyst with induced chirality

  摘要：

  在功能化的乙炔吡啶（EPy）-铂/铝氧化物催化剂上，实现了对六碳糖选择性氧化反应的速率提升。EPy配体与六碳糖反应物之间的宿主- guest相互作用生成了一种在催化剂表面引发手性复杂的复合物。

  DOI：

  10.1039/c3cc43482f
• 作为产物：
  描述：

  2,6-二溴-4-(4,4,5,5-四甲基-1,3,2-二噁硼烷-2-基)吡啶 在 Oxone 、 sodium hydride 作用下， 以 四氢呋喃 、 水 、 丙酮 为溶剂， 生成 2,6-dibromo-4-(methoxymethoxy)pyridine
  参考文献：
  名称：

  Rate enhancement of hexose sugar oxidation on an ethynylpyridine-functionalized Pt/Al2O3 catalyst with induced chirality

  摘要：

  在功能化的乙炔吡啶（EPy）-铂/铝氧化物催化剂上，实现了对六碳糖选择性氧化反应的速率提升。EPy配体与六碳糖反应物之间的宿主- guest相互作用生成了一种在催化剂表面引发手性复杂的复合物。

  DOI：

  10.1039/c3cc43482f

文献信息

• 含嘧啶并二氢吡唑啉酮类衍生物、其药学上可接受的盐及其制备方法和应用
  申请人：优领医药科技（香港）有限公司

  公开号：CN115838375A

  公开（公告）日：2023-03-24

  本发明公开了一种含嘧啶并二氢吡唑啉酮类衍生物、其药学上可接受的盐及其制备方法和应用。本发明提供了一种含嘧啶并二氢吡唑啉酮类衍生物、其立体异构体或其药学上可接受的盐。该化合物能够抑制Wee1，且对Plk1具有较佳的选择性，可治疗癌症。
• Saccharide Recognition-Induced Transformation of Pyridine−Pyridone Alternate Oligomers from Self-Dimer to Helical Complex
  作者：Hajime Abe、Hiroshi Machiguchi、Shinya Matsumoto、Masahiko Inouye

  DOI：10.1021/jo800599w

  日期：2008.6.1

  Co-oligomers involving (1H)-4-pyridone and 4-alkoxypyridine rings were studied, and it was found that their supramolecular transformation was caused by saccharide recognition-In the co-oligomers, pyridone and pyridine rings are alternately linked at their 2,6-position with an acetylene bond. The pyridine rings behave as a hydrogen bonding acceptor, and the pyridone rings and tautomerized 4-pyridinol work as a donor. Pyridine-pyridone-pyridine 3-mer was found to self-dimerize on the basis of vapor pressure osmometry in CHCl3, and the association constant was obtained as 2.3 x 10(3) M-1 by H-1 NMR titration. Longer 5-, 7-, 9-, and 11-mer oligomers showed considerable broadening and anisotropy in the H-1 NMR spectra due to self-association. These longer oligomers recognized octyl beta-D-glucopyranoside and changed their form into a chiral helical complex, showing characteristic circular dichroism.
• Remarkably Strong, Uncharged Hydrogen-Bonding Interactions of Polypyridine-Macrocyclic Receptors for Deoxyribofuranosides
  作者：Masahiko Inouye、Kunihide Takahashi、Hiroyuki Nakazumi

  DOI：10.1021/ja983539u

  日期：1999.1.1

  Novel macrocyclic saccharide receptors that possess a pyridine-pyridone-pyridine arrangement as a hydrogen-bonding motif are presented. The artificial receptors exhibited a remarkably strong binding affinity for deoxyribofuranoside derivatives in CDCl3 (K-a = 19 000 M-1 -Delta G(298) = 24.4 kJ/mol), one of the highest values of artificial receptors having only uncharged hydrogen-bonding sites for monosaccharide derivatives. Selective extraction of deoxyribose by the receptors was also observed; the extractabilities,;or affinities to the receptors of various pentoses and hexoses, decreased in the following order: deoxyribose > lyxose congruent to ribose > arabinose congruent to fructose congruent to xylose > glucose > mannose > galactose.