N-benzyl-5-cyano-2-methyl-6-oxo-1,6-dihydropyridine-3-carboxamide | 1256945-18-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: N-benzyl-5-cyano-2-methyl-6-oxo-1,6-dihydropyridine-3-carboxamide
• 英文别名: N-benzyl-5-cyano-2-methyl-6-oxo-1H-pyridine-3-carboxamide
• CAS: 1256945-18-2
• 化学式: C₁₅H₁₃N₃O₂
• 分子量: 267.287
• InChiKey: AMTIHIBIDCIRSC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  82
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  5-cyano-2-methyl-6-oxo-1H-pyridine-3-carbonyl chloride 、 苄胺 在 三乙胺 作用下， 以 二氯甲烷 、 乙酸乙酯 为溶剂， 生成 N-benzyl-5-cyano-2-methyl-6-oxo-1,6-dihydropyridine-3-carboxamide
  参考文献：
  名称：

  Effect of milrinone analogues on intracellular calcium increase in single living H9C2 cardiac cells

  摘要：

  The synthesis of milrinone analogues where the 4-pyridyl moiety was replaced by an ester or amide group is reported. Only amide derivatives are able to support intracellular calcium influx following chemical depolarization with 60 mM KCI in a percentage varying from 20 to 45% of differentiated H9C2 cardiomyocytes. Those cells were differentiated after chronic exposure to 10 nM retinoic acid which induces the expression of voltage-gated calcium channels. Analogues of milrinone containing an ester function did not show significant activity. (C) 2010 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2010.08.001

文献信息

• Effect of milrinone analogues on intracellular calcium increase in single living H9C2 cardiac cells
  作者：Tiziana Pietrangelo、Letizia Giampietro、Barbara De Filippis、Rita La Rovere、Stefania Fulle、Rosa Amoroso

  DOI：10.1016/j.ejmech.2010.08.001

  日期：2010.11

  The synthesis of milrinone analogues where the 4-pyridyl moiety was replaced by an ester or amide group is reported. Only amide derivatives are able to support intracellular calcium influx following chemical depolarization with 60 mM KCI in a percentage varying from 20 to 45% of differentiated H9C2 cardiomyocytes. Those cells were differentiated after chronic exposure to 10 nM retinoic acid which induces the expression of voltage-gated calcium channels. Analogues of milrinone containing an ester function did not show significant activity. (C) 2010 Elsevier Masson SAS. All rights reserved.