(4-chloro-methylbenzyl)pyridin-2-ylmethyl-phosphoramidic acid diethyl ester 、 6-diethoxyphosphoryl-3,6,17-triazabicyclo[11.3.1]heptadeca-1(17),13,15-triene 在
potassium carbonate 作用下,
以
乙腈 为溶剂,
反应 18.0h,
以62%的产率得到N-[3-(6-diethoxyphosphoryl-3,6,17-triazabicyclo[11.3.1]heptadeca-1(17),13,15-trienyl)-1,4-phenylenebis(methylene)]-N-(diethoxyphosphoryl)-2-(aminomethyl)pyridine