DL-α-Linoloyl-β-oleoyl-glycerin | 104485-08-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: DL-α-Linoloyl-β-oleoyl-glycerin
• 英文别名: α-Linoloyl-β-oleoyl-glycerin；α-Linoleoyl-β-oleoyl-glycerin；1-Linoleoyl-2-oleoyl-rac-glycerol；[1-hydroxy-3-[(9Z,12Z)-octadeca-9,12-dienoyl]oxypropan-2-yl] (Z)-octadec-9-enoate
• CAS: 104485-08-7
• 化学式: C₃₉H₇₀O₅
• 分子量: 618.982
• InChiKey: FQNNBQJKEBDPQS-LTEAFHAISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  13.7
• 重原子数：
  44
• 可旋转键数：
  35
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  72.8
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  9,10,12,13-Tetrabromo-octadecanoic acid 2-(9,10-dibromo-octadecanoyloxy)-3-hydroxy-propyl ester 在 锌 作用下， 生成 DL-α-Linoloyl-β-oleoyl-glycerin
  参考文献：
  名称：

  Shvets,V.I. et al., Journal of general chemistry of the USSR, 1963, vol. 33, p. 1794 - 1797

  摘要：

  DOI：

文献信息

• MGAT2, a Monoacylglycerol Acyltransferase Expressed in the Small Intestine
  作者：Chi-Liang Eric Yen、Robert V. Farese

  DOI：10.1074/jbc.m301633200

  日期：2003.5

  Acyl CoA:monoacylglycerol acyltransferase (MGAT) catalyzes the synthesis of diacylglycerol, a precursor of triacylglycerol. In the intestine, MGAT plays a major role in the absorption of dietary fat by catalyzing the resynthesis of triacylglycerol in enterocytes. This resynthesis is required for the assembly of lipoproteins that transport absorbed fat to other tissues. Despite intense efforts, a gene encoding an intestinal MGAT has not been found. Previously, we identified a gene encoding MGAT1, which in mice is expressed in the stomach, kidney, adipose tissue, and liver but not in the intestine. We now report the identification of homologous genes in humans and mice encoding MGAT2. Expression of the MGAT2 cDNA in either insect or mammalian cells markedly increased MGAT activity in cell membranes. MGAT activity was proportional to the level of MGAT2 protein expressed, and the amount of diacylglycerol produced depended on the concentration of MGAT substrates (fatty acyl CoA or monoacylglycerol). In humans, the MGAT2 gene is highly expressed in the small intestine, liver, stomach, kidney, colon, and white adipose tissue; in mice, it is expressed predominantly in the small intestine. The discovery of the MGAT2 gene will facilitate studies to determine the functional role of MGAT2 in fat absorption in the intestine and to determine whether blocking MGAT activity in enterocytes is a feasible approach to inhibit fat absorption and treat obesity.
• Shvets,V.I. et al., Journal of general chemistry of the USSR, 1963, vol. 33, p. 1794 - 1797
  作者：Shvets,V.I. et al.

  DOI：——

  日期：——