N-methyl-2-{[7-oxo-3-(2,4,6-trifluorobenzoyl)-l,7-dihydro-6H-pyrrolo[2,3-c]pyridin-6-yl]methyl}-1H-benzimidazole-5-carboxamide | 1201596-53-3

• 分子结构分类: 有机化合物
• 英文名称: N-methyl-2-{[7-oxo-3-(2,4,6-trifluorobenzoyl)-l,7-dihydro-6H-pyrrolo[2,3-c]pyridin-6-yl]methyl}-1H-benzimidazole-5-carboxamide
• 英文别名: N-methyl-2-{[7-oxo-3-(2,4,6-trifluorobenzoyl)-1,7-dihydro-6H-pyrrolo[2,3-c]pyridin-6-yl]methyl}-1H-benzimidazole-5-carboxamide；N-methyl-2-[[7-oxo-3-(2,4,6-trifluorobenzoyl)-1H-pyrrolo[2,3-c]pyridin-6-yl]methyl]-3H-benzimidazole-5-carboxamide
• CAS: 1201596-53-3
• 化学式: C₂₄H₁₆F₃N₅O₃
• 分子量: 479.418
• InChiKey: VPGXENKXUFYMPQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  35
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  111
• 氢给体数：
  3
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  2-{[7-oxo-3-(2,4,6-trifluorobenzoyl)-1,7-dihydro-6H-pyrrolo[2,3-c]pyridin-6-yl]methyl}-1H-benzimidazole-5-carboxylic acid 、 methylamine ethyl alcohol 在 乙胺 作用下， 生成 N-methyl-2-{[7-oxo-3-(2,4,6-trifluorobenzoyl)-l,7-dihydro-6H-pyrrolo[2,3-c]pyridin-6-yl]methyl}-1H-benzimidazole-5-carboxamide
  参考文献：
  名称：

  PYRROLO [2,3-C] PYRIDINE DERIVATIVES AS P38 KINEASE INHIBITING AGENTS

  摘要：

  化学式（I）描述的化合物或其药学上可接受的盐：（A）是p38的抑制剂，可用于治疗炎症，例如哮喘、类风湿性关节炎、类风湿性脊柱炎、骨关节炎、痛风性关节炎和其他关节炎症状；炎症关节、湿疹、牛皮癣或其他炎症性皮肤病，如晒伤；炎症性眼部疾病，包括结膜炎；与炎症相关的发热、疼痛和其他症状。

  公开号：

  US20110105430A1

文献信息

• [EN] PYRROLO [2, 3-C] PYRIDINE DERIVATIVES AS P38 KINASE INHIBITING AGENTS<br/>[FR] DÉRIVÉS DE PYRROLO[2,3-C]PYRIDINE EN TANT QU'INHIBITEURS DE KINASE P38
  申请人：MERCK & CO INC

  公开号：WO2009152072A1

  公开（公告）日：2009-12-17

  Compounds described by the chemical formula (I) or pharmaceutically acceptable salts thereof: (A) are inhibitors of p38 and are useful in the treatment of inflammation such as in the treatment of asthma, rheumatoid arthritis, rheumatoid spondylitis, osteoarthritis, gouty arthritis and other arthritic conditions; inflamed joints, eczema, psoriasis or other inflammatory skin conditions such as sunburn; inflammatory eye conditions including conjunctivitis; pyresis, pain and other conditions associated with inflammation.

  化学式（I）描述的化合物或其药用盐：（A）是p38的抑制剂，可用于治疗炎症，如哮喘、类风湿关节炎、类风湿脊柱炎、骨关节炎、痛风性关节炎和其他关节炎症状；发炎关节、湿疹、牛皮癣或其他炎症性皮肤症状，如晒伤；炎症性眼部疾病，包括结膜炎；发热、疼痛和其他与炎症相关的症状。
• P38 KINASE INHIBITING AGENTS
  申请人：Sahoo Soumya P.

  公开号：US20090325953A1

  公开（公告）日：2009-12-31

  Compounds described by the chemical formula (I) or pharmaceutically acceptable salts thereof: are inhibitors of p38 and are useful in the treatment of inflammation such as in the treatment of asthma, COPD, ARDS, rheumatoid arthritis, rheumatoid spondylitis, osteoarthritis, gouty arthritis and other arthritic conditions; inflamed joints, eczema, psoriasis or other inflammatory skin conditions such as sunburn; inflammatory eye conditions including conjunctivitis; pyresis, pain and other conditions associated with inflammation.

  化学式（I）或其药学上可接受的盐所描述的化合物：它们是p38的抑制剂，可用于治疗炎症，如哮喘、COPD、ARDS、类风湿关节炎、类风湿脊柱炎、骨关节炎、痛风性关节炎和其他关节炎症状；发炎的关节、湿疹、牛皮癣或其他炎症性皮肤状况，如晒伤；炎症性眼部状况，包括结膜炎；发热、疼痛和其他与炎症有关的状况。
• P38 kinase inhibiting agents
  申请人：Merck Sharp & Dohme Corp.

  公开号：US08017605B2

  公开（公告）日：2011-09-13

  Compounds described by the chemical formula (I) or pharmaceutically acceptable salts thereof: are inhibitors of p38 and are useful in the treatment of inflammation such as in the treatment of asthma, COPD, ARDS, rheumatoid arthritis, rheumatoid spondylitis, osteoarthritis, gouty arthritis and other arthritic conditions; inflamed joints, eczema, psoriasis or other inflammatory skin conditions such as sunburn; inflammatory eye conditions including conjunctivitis; pyresis, pain and other conditions associated with inflammation.

  化学式为（I）或其药学上可接受的盐所描述的化合物：是p38抑制剂，可用于治疗炎症，例如哮喘，COPD，ARDS，类风湿性关节炎，类风湿性脊柱炎，骨关节炎，痛风性关节炎和其他关节炎症状；炎症性关节，湿疹，牛皮癣或其他炎症性皮肤病，例如晒伤；包括结膜炎在内的炎症性眼病；与炎症相关的发热，疼痛和其他症状。
• PYRROLO-[2, 3-C]-PYRIDINE DERIVATIVES AS P38 KINASE INHIBITING AGENTS
  申请人：Merck Sharp & Dohme Corp.

  公开号：EP2300485B1

  公开（公告）日：2012-01-18
• PYRROLO Ý2, 3-C¨PYRIDINE DERIVATIVES AS P38 KINASE INHIBITING AGENTS
  申请人：Merck Sharp & Dohme Corp.

  公开号：EP2300485A1

  公开（公告）日：2011-03-30