2-[(Pyridin-2-ylmethyl)-amino]-benzoic acid methyl ester | 880494-17-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[(Pyridin-2-ylmethyl)-amino]-benzoic acid methyl ester
• 英文别名: Methyl 2-[(pyridin-2-ylmethyl)amino]benzoate；methyl 2-(pyridin-2-ylmethylamino)benzoate
• CAS: 880494-17-7
• 化学式: C₁₄H₁₄N₂O₂
• mdl: MFCD11178984
• 分子量: 242.277
• InChiKey: ZDSSMOFQNIHBTJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.142
• 拓扑面积：
  51.2
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-[(Pyridin-2-ylmethyl)-amino]-benzoic acid methyl ester 在 一水合肼 作用下， 以 异丙醇 为溶剂， 生成
  参考文献：
  名称：

  Oxadiazole derivatives as a novel class of antimitotic agents: Synthesis, inhibition of tubulin polymerization, and activity in tumor cell lines

  摘要：

  Oxadiazole derivatives were synthesized and evaluated for their ability to inhibit tubulin polymerization and to cause mitotic arrest in tumor cells. The most potent compounds inhibited tubulin polymerization at concentrations below 1 mu M. Lead analogs caused mitotic arrest of A431 human epidermoid cells and cells derived from multi-drug resistant tumors (10, EC50 = 7.8 nM). Competition for the colchicine binding site and pharmacokinetic properties of selected potent compounds were also investigated and are reported herein, along with structure-activity relationships for this novel series of antimitotic agents. (C) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.11.094
• 作为产物：
  描述：

  吡啶-2-甲醛 在 硫酸 作用下， 以 甲醇 为溶剂， 反应 53.0h， 生成 2-[(Pyridin-2-ylmethyl)-amino]-benzoic acid methyl ester
  参考文献：
  名称：

  用 2-吡啶甲胺受体基团功能化的荧光 Zr(IV) 金属-有机框架检测和吸附水介质中的重金属离子

  摘要：

  重金属离子导致的全球环境污染日益严重，这提高了研究新型多功能材料以同时检测和去除水资源中这些污染物的重要性。在这项研究中，我们报道了一种基于对苯二甲酸酯配体的微孔 8 连接 Zr 4+金属有机骨架 (MOF)，该配体装饰有螯合 2-吡啶甲胺侧基 ( dMOR-2 )，它显示出高效的荧光传感和吸附重金属阳离子。我们通过详细的荧光研究证明了dMOR-2与聚乙烯吡咯烷酮的水分散性复合材料实时检测 Cu 2+、Pb 2+和 Hg 2+的能力在水性介质中。发现这些物种的检测限低于 2 ppb，而系统的性能不受其他潜在竞争离子存在的影响。此外，吸附研究表明，dMOR-2与海藻酸钙的复合材料 ( dMOR-2@CaA ) 是一种出色的 Pb 2+和 Cu 2+离子吸附剂，容量分别为 376 ± 15 和 117 ± 4 mg/g dMOR-2@CaA，同时显示出在低初始浓度和大量过量的其他阳离子物质存在

  DOI：

  10.1021/acs.inorgchem.2c00434

文献信息

• Oxadiazole derivatives as a novel class of antimitotic agents: Synthesis, inhibition of tubulin polymerization, and activity in tumor cell lines
  作者：Xiaohu Ouyang、Evgueni L. Piatnitski、Vatee Pattaropong、Xiaoling Chen、Hai-Ying He、Alexander S. Kiselyov、Avdhoot Velankar、Joel Kawakami、Marc Labelle、Leon Smith、Julia Lohman、Sui Ping Lee、Asra Malikzay、James Fleming、Jason Gerlak、Ying Wang、Robin L. Rosler、Kai Zhou、Stan Mitelman、Margarita Camara、David Surguladze、Jacqueline F. Doody、M. Carolina Tuma

  DOI：10.1016/j.bmcl.2005.11.094

  日期：2006.3

  Oxadiazole derivatives were synthesized and evaluated for their ability to inhibit tubulin polymerization and to cause mitotic arrest in tumor cells. The most potent compounds inhibited tubulin polymerization at concentrations below 1 mu M. Lead analogs caused mitotic arrest of A431 human epidermoid cells and cells derived from multi-drug resistant tumors (10, EC50 = 7.8 nM). Competition for the colchicine binding site and pharmacokinetic properties of selected potent compounds were also investigated and are reported herein, along with structure-activity relationships for this novel series of antimitotic agents. (C) 2005 Elsevier Ltd. All rights reserved.
• Detection and Sorption of Heavy Metal Ions in Aqueous Media by a Fluorescent Zr(IV) Metal–Organic Framework Functionalized with 2-Picolylamine Receptor Groups
  作者：Stavros A. Diamantis、Anastasia D. Pournara、Eirini D. Koutsouroubi、Constantinos Moularas、Yiannis Deligiannakis、Gerasimos S. Armatas、Antonios G. Hatzidimitriou、Manolis J. Manos、Theodore Lazarides

  DOI：10.1021/acs.inorgchem.2c00434

  日期：2022.5.23

  which shows highly efficient fluorescence sensing and sorption of heavy metal cations. We demonstrate by detailed fluorescence studies the ability of a water-dispersible composite of dMOR-2 with polyvinylpyrrolidone for real-time detection of Cu2+, Pb2+, and Hg2+ in aqueous media. The limits of detection were found to be below 2 ppb for these species, while the system’s performance is not affected by

  重金属离子导致的全球环境污染日益严重，这提高了研究新型多功能材料以同时检测和去除水资源中这些污染物的重要性。在这项研究中，我们报道了一种基于对苯二甲酸酯配体的微孔 8 连接 Zr 4+金属有机骨架 (MOF)，该配体装饰有螯合 2-吡啶甲胺侧基 ( dMOR-2 )，它显示出高效的荧光传感和吸附重金属阳离子。我们通过详细的荧光研究证明了dMOR-2与聚乙烯吡咯烷酮的水分散性复合材料实时检测 Cu 2+、Pb 2+和 Hg 2+的能力在水性介质中。发现这些物种的检测限低于 2 ppb，而系统的性能不受其他潜在竞争离子存在的影响。此外，吸附研究表明，dMOR-2与海藻酸钙的复合材料 ( dMOR-2@CaA ) 是一种出色的 Pb 2+和 Cu 2+离子吸附剂，容量分别为 376 ± 15 和 117 ± 4 mg/g dMOR-2@CaA，同时显示出在低初始浓度和大量过量的其他阳离子物质存在