4-Dipropylamino-buttersaeure | 105538-52-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 4-Dipropylamino-buttersaeure
• 英文别名: γ-Di-n-propylamino-buttersaeure；4-(Dipropylazaniumyl)butanoate
• CAS: 105538-52-1
• 化学式: C₁₀H₂₁NO₂
• 分子量: 187.282
• InChiKey: KFIQIGCCTMBCOH-UHFFFAOYSA-N

物化性质

• 熔点：
  229 °C
• 沸点：
  289.8±23.0 °C(Predicted)
• 密度：
  0.958±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  13
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  44.6
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  γ-Di-n-propylamino-buttersaeure-methylester 在 盐酸 作用下， 生成 4-Dipropylamino-buttersaeure
  参考文献：
  名称：

  Intramolecular Assistance of Decarboxylative Acylation

  摘要：

  DOI：

  10.1021/ja01474a024

文献信息

• NANOMATERIALS
  申请人：Guide Therapeutics, Inc.

  公开号：US20210169804A1

  公开（公告）日：2021-06-10

  Lipid nanoparticle compositions for delivery of nucleic acids are described. The lipid nanoparticle may contain a conformationally constrained ionizable lipid as part of the composition. These compositions may allow for delivery of cargo without the need for a targeting ligand.

  描述了用于传递核酸的脂质纳米粒子组合物。脂质纳米粒子可能包含作为组合物的一部分的构象受限的可离子化脂质。这些组合物可能允许传递货物而无需靶向配体。
• Prodrugs of rapamycin
  申请人：THE UNIVERSITY OF KANSAS

  公开号：EP0227355A2

  公开（公告）日：1987-07-01

  Water soluble prodrugs of rapamycin are disclosed which are useful as components in injectable pharmaceutical formulations for the treatment of tumors in mammals. Said prodrugs are rapamycin derivatives or salts thereof mono substituted at position 28 or disubstituted at position 28 or and 43 by acylamino substituent of formula wherein m is an integer from 1 to 3 and R1 and R2 are each hydrogen or an alkyl radical having from 1 to 3 carbon atoms or R1 and R2 together with the nitrogen atom to which they are attached form a saturated heterocyclic ring having 4-5 carbon atoms.

  本发明公开了雷帕霉素的水溶性原药，可用作治疗哺乳动物肿瘤的注射药物制剂的成分。 所述原药为雷帕霉素衍生物或其盐，在28位被单取代，或在28位或43位被酰氨基取代，式中m为1至3的整数，R1和R2各自为氢或具有1至3个碳原子的烷基，或R1和R2与所连接的氮原子一起形成具有4至5个碳原子的饱和杂环。
• COREATANT-INCLUDING ELECTROCHEMILUMINESCENT COMPOUNDS, METHODS, SYSTEMS AND KITS UTILIZING SAME
  申请人：——

  公开号：US20010003647A1

  公开（公告）日：2001-06-14

  A method of generating a electrochemiluminescent emission, which comprises exposing an electrochemiluminescent label linked to a coreactant, to conditions suitable for inducing electrochemiluminescence; said compound; a system for generating an electrochemiluminescent emission, which comprises said compound, means for exposing said compound to electrochemical energy, and means for detecting or measuring luminescence emitted from said compound or a composition containing same; and a kit for performing an assay using said compound.

  一种产生电致发光的方法，包括将与核心反应物相连的电致发光标记暴露于适合诱导电致发光的条件下；所述化合物；一种产生电致发光的系统，包括所述化合物、将所述化合物暴露于电化学能量的装置，以及检测或测量从所述化合物或含有该化合物的组合物发出的发光的装置；以及一种使用所述化合物进行检测的试剂盒。
• Coreactant-including electrochemiluminescent compounds, methods, systems and kits utilizing same
  申请人：IGEN International, Inc.

  公开号：US20010018187A1

  公开（公告）日：2001-08-30

  A method of generating a electrochemiluminescent emission, which comprises exposing an electrochemiluminescent label linked to a coreactant, to conditions suitable for inducing electrochemiluminescence; said compound; a system for generating an electrochemiluminescent emission, which comprises said compound, means for exposing said compound to electrochemical energy, and means for detecting or measuring luminescence emitted from said compound or a composition containing same; and a kit for performing an assay using said compound.

  一种产生电致发光的方法，包括将与核心反应物相连的电致发光标记暴露于适合诱导电致发光的条件下；所述化合物；一种产生电致发光的系统，包括所述化合物、将所述化合物暴露于电化学能量的装置，以及检测或测量从所述化合物或含有该化合物的组合物发出的发光的装置；以及一种使用所述化合物进行检测的试剂盒。
• WERMUTH C. -G.; BOURGUIGNON J. -J.; SCHLEWER G.; GIES J. -P.; SCHOENFELDE+, J. MED. CHEM., 30,(1987) N 2, 239-249
  作者：WERMUTH C. -G.、 BOURGUIGNON J. -J.、 SCHLEWER G.、 GIES J. -P.、 SCHOENFELDE+

  DOI：——

  日期：——