(+/-)-tert-butyl 2-[(isobutyl{[9-(tetrahydro-2H-pyran-2-yloxy)-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-yl]methyl}amino)carbonyl]morpholine-4-carboxylate | 941710-39-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: (+/-)-tert-butyl 2-[(isobutyl{[9-(tetrahydro-2H-pyran-2-yloxy)-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-yl]methyl}amino)carbonyl]morpholine-4-carboxylate
• 英文别名: (+/-)-tert-butyl 2-[(isobutyl {[9-(tetrahydro-2H-pyran-2-yloxy)-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-yl]methyl}amino)carbonyl]morpholine-4-carboxylate；tert-butyl 2-[2-methylpropyl-[[5-(oxan-2-yloxy)-6,7,8,9-tetrahydro-5H-benzo[7]annulen-3-yl]methyl]carbamoyl]morpholine-4-carboxylate
• CAS: 941710-39-0
• 化学式: C₃₁H₄₈N₂O₆
• 分子量: 544.732
• InChiKey: WQQAPRFBAAGFGU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  39
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.74
• 拓扑面积：
  77.5
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  (+/-)-tert-butyl 2-[(isobutyl{[9-(tetrahydro-2H-pyran-2-yloxy)-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-yl]methyl}amino)carbonyl]morpholine-4-carboxylate 在 4-甲基苯磺酸吡啶 作用下， 以 乙醇 为溶剂， 生成 (+/-)-tert-butyl 2-{[[(9-hydroxy-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-yl)methyl](isobutyl)amino]-carbonyl}morpholine-4-carboxylate
  参考文献：
  名称：

  WO2007/67511

  摘要：

  公开号：

文献信息

• Morpholine Carboxamide Prokineticin Receptor Antagonists
  申请人：Thompson Wayne J.

  公开号：US20090306076A1

  公开（公告）日：2009-12-10

  The present invention is directed to morpholine carboxamide compounds which are antagonists of prokineticin receptors, in particular antagonists of prokineticin 2 receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which prokineticin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which prokineticin receptors are involved.

  本发明涉及形态啉羧酰胺化合物，其为促动素受体拮抗剂，特别是促动素2受体拮抗剂，可用于治疗或预防神经和精神障碍和疾病，其中涉及促动素受体。本发明还涉及包含这些化合物的制药组合物以及在涉及促动素受体的这种疾病的预防或治疗中使用这些化合物和组合物的用途。
• Morpholine carboxamide prokineticin receptor antagonists
  申请人：Merck Sharp & Dohme. Corp.

  公开号：US07855201B2

  公开（公告）日：2010-12-21

  The present invention is directed to morpholine carboxamide compounds which are antagonists of prokineticin receptors, in particular antagonists of prokineticin 2 receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which prokineticin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which prokineticin receptors are involved.

  本发明涉及形态咪唑羧酰胺化合物，其为促动素受体的拮抗剂，特别是促动素2受体的拮抗剂，并且在治疗或预防神经系统和精神障碍及疾病中起作用，其中涉及促动素受体。本发明还涉及包含这些化合物的制药组合物以及在涉及促动素受体的这类疾病的预防或治疗中使用这些化合物和组合物。
• MORPHOLINE CARBOXAMIDE PROKINETICIN RECEPTOR ANTAGONISTS
  申请人：Merck Sharp & Dohme Corp.

  公开号：EP1959959B1

  公开（公告）日：2013-04-10
• US7855201B2
  申请人：——

  公开号：US7855201B2

  公开（公告）日：2010-12-21