2-(2,4,6-Trimethoxyphenyl)ethenesulfonic acid (3-amino-4-methoxyphenyl)amide | 1584658-01-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(2,4,6-Trimethoxyphenyl)ethenesulfonic acid (3-amino-4-methoxyphenyl)amide
• 英文别名: 2,4,6-trimethoxystyryl-N-(3-amino-4-methoxyphenyl)-sulfonamide；N-(3-amino-4-methoxyphenyl)-2-(2,4,6-trimethoxyphenyl)ethenesulfonamide
• CAS: 1584658-01-4
• 化学式: C₁₈H₂₂N₂O₆S
• 分子量: 394.448
• InChiKey: OLRRWEXEHIWZJV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  27
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  118
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  2-(2,4,6-Trimethoxyphenyl)ethenesulfonic acid (3-amino-4-methoxyphenyl)amide 在 5%-palladium/activated carbon 、 氢气 作用下， 以 甲醇 为溶剂， 以95%的产率得到N-(3-amino-4-methoxyphenyl)-2-(2,4,6-trimethoxyphenyl)ethanesulfonamide
  参考文献：
  名称：

  [EN] SUBSTITUTED ALKYL DIARYL DERIVATIVES, METHODS OF PREPARATION AND USES
  [FR] DÉRIVÉS ALKYL DIARYLES SUBSTITUÉS, PROCÉDÉS DE PRÉPARATION ET D'UTILISATIONS

  摘要：

  公开号：

  WO2014047110A3
• 作为产物：
  描述：

  2,4,6-trimethoxystyryl-N-(4-methoxy-3-nitrophenyl)sulfonamide 、 一水合肼 在 钯 钯 、 ice 作用下， 以 乙醇 为溶剂， 反应 5.0h， 生成 2-(2,4,6-Trimethoxyphenyl)ethenesulfonic acid (3-amino-4-methoxyphenyl)amide
  参考文献：
  名称：

  ACTIVATED CYTOTOXIC COMPOUNDS FOR ATTACHMENT TO TARGETING MOLECULES FOR THE TREATMENT OF MAMMALIAN DISEASE CONDITIONS

  摘要：

  本发明涉及一种激活的细胞毒性化合物，用于附着于靶向分子治疗哺乳动物疾病状况，包括激活剂、间隔连接剂、连接剂（例如自解性连接剂）和从AMINO-SUBSTITUTED（E）-2,6-DIALKOXYSTYRYL 4-SUBSTITUTED BENZYLSULFONES、AMINO-AND-HYDROXY SUBSTITUTED STYRYLSULFONANILIDES和SUBSTITUTED PHENOXY-AND PHENYLTHIO-STYRYLSULFONE DERIVATIVES组成的细胞毒性药物。本发明还涉及附着于靶向分子的激活的细胞毒性化合物，其中靶向分子从抗体、受体、配体、细胞因子、激素和信号转导分子等组成的群体中选择。本发明进一步涉及一种治疗疾病状况的方法。

  公开号：

  US20100022615A1

文献信息

• [EN] 2,4,6-TRIALKOXYSTRYL ARYL SULFONES, SULFONAMIDES AND CARBOXAMIDES, AND METHODS OF PREPARATION AND USE<br/>[FR] 2,4,6-TRIALCOXYSTYRYLARYLSULFONES, SULFONAMIDES ET CARBOXAMIDES, ET PROCÉDÉS DE PRÉPARATION ET D'UTILISATION
  申请人：TEMPLE UNIV - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

  公开号：WO2017023912A1

  公开（公告）日：2017-02-09

  Compounds according to Formula (I) are provided and salts thereof, wherein R1, R2, R3, R4, R5, R6, R13, A, X and Y are as defined herein. Methods for preparing compounds of Formula (I) are also provided, as well as methods of treating cellular proliferative disorders, such as cancer, using compounds of Formula (I).

  根据公式（I）提供化合物及其盐，其中R1、R2、R3、R4、R5、R6、R13、A、X和Y的定义如本文所述。还提供了制备公式（I）化合物的方法，以及利用公式（I）化合物治疗细胞增殖性疾病，如癌症的方法。
• Amino-substituted sulfonanilides and derivatives thereof for treating proliferative disorders
  申请人：Reddy Premkumar E

  公开号：US20050096484A1

  公开（公告）日：2005-05-05

  Compounds useful as antiproliferative agents, including, for example, anticancer agents, are provided according to formula I: wherein: Ar, X, X 1 , g, R and R 3 are as defined herein.

  提供了作为抗增殖剂的化合物，包括例如抗癌剂，其符合以下公式I：其中：Ar，X，X1，g，R和R3的定义如下。
• Unsaturated Sulfides, Sulfones, Sulfoxides and Sulfonamides Synthesis
  申请人：Reddy M.V. Ramana

  公开号：US20090124828A1

  公开（公告）日：2009-05-14

  α,β-Unsaturated sulfides, sulfones, sulfoxides and sulfonamides according to Formula I: wherein Ar 1 , Ar 2 , X, n, * and R are as defined herein, are prepared by dehydration of β-hydroxy sulfides, sulfones, sulfoxides or sulfonamides.

  根据公式I，制备α，β-不饱和硫化物，磺酰酸，亚磺酸和磺酰胺，其中Ar1，Ar2，X，n，*和R的定义如下，通过β-羟基硫化物，磺酰酸，亚磺酸或磺酰胺的脱水反应制备。
• Activated cytotoxic compounds for attachment to targeting molecules for the treatment of mammalian disease conditions
  申请人：Onconova Therapeutics, Inc

  公开号：US08273787B2

  公开（公告）日：2012-09-25

  Activated cytotoxic compounds are described for attachment to targeting molecules for the treatment of a mammalian disease condition which comprise, an activator, a spacer linker, a linker (e.g., self-immolative), and a cytotoxic drug selected from the group consisting of AMINO-SUBSTITUTED (E)-2,6-DIALKOXYSTYRYL 4-SUBSTITUTED BENZYLSULFONES, AMINO-AND-HYDROXY SUBSTITUTED STYRYLSULFONANILIDES, and SUBSTITUTED PHENOXY- AND PHENYLTHIO-STYRYLSULFONE DERIVATIVES. Activated cytotoxic compound attached to a targeting molecule are described wherein the targeting molecule is selected from the group consisting essentially of an antibody, a receptor, a ligand, a cytokine, a hormone, and a signal transduction molecule. The invention is further directed to a method of treatment of disease conditions.

  描述了一种用于治疗哺乳动物疾病的靶向分子附着的活化细胞毒性化合物，包括激活剂、间隔连接剂、连接剂（例如，自解离型）和从AMINO-SUBSTITUTED（E）-2,6-DIALKOXYSTYRYL 4-SUBSTITUTED BENZYLSULFONES、AMINO-AND-HYDROXY SUBSTITUTED STYRYLSULFONANILIDES和SUBSTITUTED PHENOXY-AND PHENYLTHIO-STYRYLSULFONE DERIVATIVES组成的细胞毒性药物。还描述了附着于靶向分子的活化细胞毒性化合物，其中靶向分子选择自抗体、受体、配体、细胞因子、激素和信号转导分子等组成的组。本发明还涉及一种治疗疾病的方法。
• SUBSTITUTED ALKYL DIARYL DERIVATIVES, METHODS OF PREPARATION AND USES
  申请人：TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

  公开号：US20150266819A1

  公开（公告）日：2015-09-24

  Compounds according to Formula I are provided: and salts thereof, wherein Q 1 , Q 2 , R 3 , R 4 , X, and Y are as defined herein. Methods for preparing compounds of Formula I are also provided, as well as methods of treating cellular proliferative disorders, such as cancer, using compounds of Formula (I). Q 2 -X—Y—CHR 3 —CHR 4 -Q 1 (I)

  提供符合公式I的化合物和其盐，其中Q1、Q2、R3、R4、X和Y的定义如本文所述。还提供了制备公式I化合物的方法，以及使用公式（I）化合物治疗细胞增殖性疾病（如癌症）的方法。Q2-X—Y—CHR3—CHR4-Q1（I）