ethyl (E) 2-ethoxy-3-[4-[2-(5-methyl-2-phenylpyrrol-1-yl)ethoxy]phenyl]prop-2-enoate | 494851-83-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: ethyl (E) 2-ethoxy-3-[4-[2-(5-methyl-2-phenylpyrrol-1-yl)ethoxy]phenyl]prop-2-enoate
• 英文别名: ethyl (E)-2-ethoxy-3-[4-[2-(2-methyl-5-phenylpyrrol-1-yl)ethoxy]phenyl]prop-2-enoate
• CAS: 494851-83-1
• 化学式: C₂₆H₂₉NO₄
• 分子量: 419.521
• InChiKey: KAODBWFWRMXHHK-NCELDCMTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  31
• 可旋转键数：
  11
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  49.7
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  ethyl (E) 2-ethoxy-3-[4-[2-(5-methyl-2-phenylpyrrol-1-yl)ethoxy]phenyl]prop-2-enoate 以25%的产率得到(E) 3-{4-[2-(5-methyl-2-phenylpyrrol-1-yl)ethoxy]phenyl}-2-ethoxyprop-2-enoic acid
  参考文献：
  名称：

  Novel heterocyclic compounds having hypolipidemic, hypocholesteremic activities process for their preparation and pharmaceutical compositions containing them and their use in medicine

  摘要：

  具有降脂和降胆固醇活性的新型β-芳基-α-取代丙酸。

  公开号：

  US20030236254A1
• 作为产物：
  描述：

  4-[2-(5-methyl-2-phenylpyrrol-1-yl)ethoxy]benzaldehyde 、 2-乙氧基三乙基磷酸乙酯 在 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 反应 4.0h， 以15%的产率得到ethyl (E) 2-ethoxy-3-[4-[2-(5-methyl-2-phenylpyrrol-1-yl)ethoxy]phenyl]prop-2-enoate
  参考文献：
  名称：

  Novel heterocyclic compounds having hypolipidemic, hypocholesteremic activities process for their preparation and pharmaceutical compositions containing them and their use in medicine

  摘要：

  具有降脂和降胆固醇活性的新型β-芳基-α-取代丙酸。

  公开号：

  US20030236254A1

文献信息

• Novel pyrroles having hypolipidemic hypocholesteremic activities, process for their preparation and pharmaceutical compositions containing them and their use in medicine
  申请人：Lohray Braj Bhushan

  公开号：US20110275669A1

  公开（公告）日：2011-11-10

  The present invention relates to compounds of the general formula (I) their derivatives, their analogs, their tautomeric forms, their pharmaceutically acceptable salts, wherein all variables are as defined in the specification.

  本发明涉及公式（I）的化合物及其衍生物、类似物、互变异构体、药学上可接受的盐，其中所有变量如规范中所定义。
• NOVEL PYRROLES HAVING HYPOLIPIDEMIC HYPOCHOLESTEREMIC ACTIVITIES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE IN MEDICINE
  申请人：CADILA HEALTHCARE LIMITED

  公开号：EP1414439B1

  公开（公告）日：2011-05-04
• US8110598B2
  申请人：——

  公开号：US8110598B2

  公开（公告）日：2012-02-07
• Novel heterocyclic compounds having hypolipidemic, hypocholesteremic activities process for their preparation and pharmaceutical compositions containing them and their use in medicine
  申请人：——

  公开号：US20030236254A1

  公开（公告）日：2003-12-25

  Novel &bgr;-aryl-&agr;-substituted propanoic acids having hypolipidemic and hypocholesteremic activities.

  具有降脂和降胆固醇活性的新型β-芳基-α-取代丙酸。