7-(4'-Methoxybiphenyl-4-yl)-[1,6]naphthyridin-5-ol | 562105-90-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 7-(4'-Methoxybiphenyl-4-yl)-[1,6]naphthyridin-5-ol
• 英文别名: 7-[4-(4-methoxyphenyl)phenyl]-6H-1,6-naphthyridin-5-one
• CAS: 562105-90-2
• 化学式: C₂₁H₁₆N₂O₂
• 分子量: 328.37
• InChiKey: PXTTVHLNVSGXLH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  51.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-甲氧基苯硼酸 、 7-(4-bromophenyl)-1,6-naphthyridin-5-one 在 四(三苯基膦)钯 sodium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 7-(4'-Methoxybiphenyl-4-yl)-[1,6]naphthyridin-5-ol
  参考文献：
  名称：

  1,6 naphthyridines useful as inhibitors of SYK kinase

  摘要：

  揭示了公式（I）中的化合物：其中R3、R5、R7和R8在此定义，这些化合物可作为SYK激酶的抑制剂，并因此可用于治疗由于肥大细胞异常激活导致的疾病，包括过敏和炎症性疾病。还揭示了包含这些化合物的药物组合物以及制备这些化合物的方法。

  公开号：

  US20030158195A1

文献信息

• 1,6 Naphthyridines useful as inhibitors of SYK kinase
  申请人：Boehringer Ingelheim Pharmaceuticals, Inc.

  公开号：US20030229090A1

  公开（公告）日：2003-12-11

  Disclosed are compounds of formula (I): 1 wherein R 3 , R 5 , R 7 and R 8 are defined herein, which are useful as inhibitors SYK kinase and are thus useful for treating diseases resulting from inappropriate mast cell activation, which include allergic and inflammatory diseases. Also disclosed are pharmaceutical compositions comprising these compounds and processes for preparing these compounds.

  公开了式(I)的化合物：其中R3、R5、R7和R8如此定义，它们有用作SYK激酶抑制剂，并因此有用于治疗由不适当的肥大细胞活化引起的疾病，包括过敏和炎症性疾病。还公开了包含这些化合物的制药组合物和制备这些化合物的方法。
• 1,6 NAPHTHYRIDINES USEFUL AS INHIBITORS OF SYK KINASE
  申请人：CYWIN L. Charles

  公开号：US20080114024A1

  公开（公告）日：2008-05-15

  Disclosed are compounds of formula (I): wherein R 3 , R 5 , R 7 and R 8 are defined herein, which are useful as inhibitors SYK kinase and are thus useful for treating diseases resulting from inappropriate mast cell activation, which include allergic and inflammatory diseases. Also disclosed are pharmaceutical compositions comprising these compounds and processes for preparing these compounds.

  本发明涉及式(I)的化合物：其中R3、R5、R7和R8如本文所定义，其可用作抑制SYK激酶的抑制剂，因此可用于治疗由不恰当的肥大细胞激活引起的疾病，包括过敏和炎症性疾病。本发明还涉及包含这些化合物的制药组合物和制备这些化合物的方法。
• 1,6 NAPHTHRIDINES USEFUL AS INHIBITORS OF SYK KINASE
  申请人：CYWIN Charles L.

  公开号：US20090171089A1

  公开（公告）日：2009-07-02

  Disclosed are compounds of formula (I): wherein R 3 , R 5 , R 7 and R 8 are defined herein, which are useful as inhibitors SYK kinase and are thus useful for treating diseases resulting from inappropriate mast cell activation, which include allergic and inflammatory diseases. Also disclosed are pharmaceutical compositions comprising these compounds and processes for preparing these compounds.

  本发明涉及一种化合物，其化学式为（I）：其中R3，R5，R7和R8如本文所定义，这些化合物可用作SYK激酶抑制剂，因此可用于治疗由不适当的肥大细胞激活引起的疾病，包括过敏性和炎症性疾病。本发明还涉及包含这些化合物的制药组合物以及制备这些化合物的过程。
• 1,6 Naphthridines useful as inhibitors of SYK kinase
  申请人：Boehringer Ingelheim Pharmaceuticals, Inc.

  公开号：US07705151B2

  公开（公告）日：2010-04-27

  Disclosed are compounds of formula (I): wherein R3, R5, R7 and R8 are defined herein, which are useful as inhibitors SYK kinase and are thus useful for treating diseases resulting from inappropriate mast cell activation, which include allergic and inflammatory diseases. Also disclosed are pharmaceutical compositions comprising these compounds and processes for preparing these compounds.

  本发明涉及化合物I的公式：其中R3、R5、R7和R8在此定义，其作为SYK激酶抑制剂是有用的，因此可用于治疗由不适当的肥大细胞激活引起的疾病，包括过敏和炎症性疾病。还公开了包含这些化合物的制药组合物和制备这些化合物的过程。
• US7321041B2
  申请人：——

  公开号：US7321041B2

  公开（公告）日：2008-01-22