2-(3-methyl-6-formyl-2-carboxy-5-hydroxy-phenoxy)-3,5-dihydroxy-4-methyl-benzoic acid methyl ester | 1089144-06-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(3-methyl-6-formyl-2-carboxy-5-hydroxy-phenoxy)-3,5-dihydroxy-4-methyl-benzoic acid methyl ester
• 英文别名: 2-(2,4-dihydroxy-6-methoxycarbonyl-3-methylphenoxy)-3-formyl-4-hydroxy-6-methylbenzoic acid
• CAS: 1089144-06-8
• 化学式: C₁₈H₁₆O₉
• 分子量: 376.32
• InChiKey: TZHYARVFTRYXDR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  151
• 氢给体数：
  4
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  2-(3-methyl-6-formyl-2-carboxy-5-hydroxy-phenoxy)-3,5-dihydroxy-4-methyl-benzoic acid methyl ester 在 乙酸酐 作用下， 反应 5.0h， 以30%的产率得到4-formyl-3,8-dihydroxy-1,9-dimethyl-11-oxo-11H-dibenzo[b,e][1,4]dioxepine-6-carboxylic acid methyl ester
  参考文献：
  名称：

  EP2199295

  摘要：

  公开号：
• 作为产物：
  描述：

  2-(3-methyl-6-formyl-2-carboxy-5-methoxy-phenoxy)-3,5-dimethoxy-4-methyl-benzoic acid methyl ester 在 三氯化硼 作用下， 以 二氯甲烷 为溶剂， 以87%的产率得到2-(3-methyl-6-formyl-2-carboxy-5-hydroxy-phenoxy)-3,5-dihydroxy-4-methyl-benzoic acid methyl ester
  参考文献：
  名称：

  EP2199295

  摘要：

  公开号：

文献信息

• Heptacyclic compounds and the pharmaceutical uses thereof for preventing and treating diabetes and metabolic syndrome
  申请人：Shanghai Institute of Materia Medica Chinese Academy of Sciences

  公开号：US08158623B2

  公开（公告）日：2012-04-17

  The invention discloses a new use of a class of heptacyclic compounds in the preparation of formulations for the prevention and treatment of diabetes and metabolic syndromes; the present invention also discloses a new class of heptacyclic compounds; the present invention also discloses a process for preparing the heptacyclic compounds and a composition containing the same. The heptacyclic compounds of the present invention can be used to effectively preventing or treating diseases such as diabetes and metabolic syndromes.

  本发明揭示了一类七环化合物在制备用于预防和治疗糖尿病和代谢综合征的配方中的新用途；本发明还揭示了一类新的七环化合物；本发明还揭示了制备七环化合物和含有七环化合物的组合物的方法。本发明的七环化合物可用于有效地预防或治疗糖尿病和代谢综合征等疾病。
• HEPTACYCLIC COMPOUNDS AND THE PHARMACEUTICAL USES THEREOF FOR PREVENTING AND TREATING DIABETES AND METABOLIC SYNDROME
  申请人：Shen Jianhua

  公开号：US20100173905A1

  公开（公告）日：2010-07-08

  The invention discloses a new use of a class of heptacyclic compounds in the preparation of formulations for the prevention and treatment of diabetes and metabolic syndromes; the present invention also discloses a new class of heptacyclic compounds; the present invention also discloses a process for preparing the heptacyclic compounds and a composition containing the same. The heptacyclic compounds of the present invention can be used to effectively preventing or treating diseases such as diabetes and metabolic syndromes.

  本发明公开了一类七环化合物在制备用于预防和治疗糖尿病和代谢综合症的配方中的新用途；本发明还公开了一类新的七环化合物；本发明还公开了一种制备七环化合物和含有七环化合物的组成物的方法。本发明的七环化合物可用于有效地预防或治疗糖尿病和代谢综合症等疾病。
• COMPOUNDS WITH 7-MEMBER CYCLE AND THE PHARMACEUTICAL USE THEREOF FOR PREVENTING AND TREATING DIABETES AND METABOLISM SYNDROME
  申请人：Shanghai Institute of Materia Medica, Chinese Academy of Sciences

  公开号：EP2199295A1

  公开（公告）日：2010-06-23

  The invention discloses a new use of a class of heptacyclic compounds in the preparation of formulations for the prevention and treatment of diabetes and metabolic syndromes; the present invention also discloses a new class of heptacyclic compounds; the present invention also discloses a process for preparing the heptacyclic compounds and a composition containing the same. The heptacyclic compounds of the present invention can be used to effectively preventing or treating diseases such as diabetes and metabolic syndromes.

  本发明公开了一类庚环化合物在制备预防和治疗糖尿病和代谢综合征的制剂中的新用途；本发明还公开了一类新的庚环化合物；本发明还公开了制备庚环化合物和含有庚环化合物的组合物的工艺。本发明的庚环化合物可用于有效预防或治疗糖尿病和代谢综合征等疾病。
• US8158623B2
  申请人：——

  公开号：US8158623B2

  公开（公告）日：2012-04-17
• EP2199295
  申请人：——

  公开号：——

  公开（公告）日：——