5,6-difluoro-N1-(2-fluoro-4-iodophenyl)-3-(2-methoxyethoxy)benzene-1,2-diamine | 923033-18-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 5,6-difluoro-N1-(2-fluoro-4-iodophenyl)-3-(2-methoxyethoxy)benzene-1,2-diamine
• 英文别名: 3,4-difluoro-2-N-(2-fluoro-4-iodophenyl)-6-(2-methoxyethoxy)benzene-1,2-diamine
• CAS: 923033-18-5
• 化学式: C₁₅H₁₄F₃IN₂O₂
• 分子量: 438.188
• InChiKey: BVGYVERMFYGEMV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  23
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  56.5
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  1-烯丙基环丙磺酰氯 、 5,6-difluoro-N1-(2-fluoro-4-iodophenyl)-3-(2-methoxyethoxy)benzene-1,2-diamine 以to obtain the title product (230 mg, 78%)的产率得到1-allyl-N-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-(2-methoxyethoxy)phenyl)cyclopropane-1-sulfonamide
  参考文献：
  名称：

  DERIVATIVES OF N-(ARYLAMINO) SULFONAMIDES AS INHIBITORS OF MEK

  摘要：

  这项发明涉及N-(2-芳基氨基)芳基磺酰胺，它们是MEK抑制剂，并且在治疗癌症和其他过度增殖性疾病中有用。

  公开号：

  US20080058340A1

文献信息

• DERIVATIVES OF N-(ARYLAMINO) SULFONAMIDES INCLUDING POLYMORPHS AS INHIBITORS OF MEK AS WELL AS COMPOSITIONS, METHODS OF USE AND METHODS FOR PREPARING THE SAME
  申请人：Vernier Jean-Michel

  公开号：US20110060049A1

  公开（公告）日：2011-03-10

  This invention concerns N-(2-arylamino) aryl sulfonamide compounds which are inhibitors of MEK including crystalline polymorphic forms which exhibit a specific powder x-ray diffraction profile and/or a specific differential scanning calorimetry profile. This invention also concerns pharmaceutical compositions comprising the compounds described herein and methods of use of the compounds and compositions described herein, including the use in the treatment and/or prevention of cancer, hyperproliferative diseases and inflammatory conditions. The invention also concerns methods of making the compounds and compositions described herein.

  本发明涉及N-(2-芳基氨基)芳基磺酰胺化合物，其是MEK抑制剂，包括具有特定粉末X射线衍射谱和/或特定差示扫描量热谱的晶体多态形式。本发明还涉及包含所述化合物的制药组合物及所述化合物和组合物的使用方法，包括在治疗和/或预防癌症、高增殖性疾病和炎症疾病中的使用。本发明还涉及制备所述化合物和组合物的方法。
• Derivatives of N-(arylamino) sulfonamides as inhibitors of MEK
  申请人：Ardea Biosciences

  公开号：US07759518B2

  公开（公告）日：2010-07-20

  This invention concerns N-(2-arylamino)aryl sulfonamides, which are inhibitors of MEK and are useful in treatment of cancer and other hyperproliferative diseases.

  这项发明涉及N-(2-芳基氨基)芳基磺酰胺，它们是MEK的抑制剂，并且在治疗癌症和其他过度增殖性疾病方面非常有用。
• DERIVATIVES OF N-(ARYLAMINO)SULFONAMIDES AS INHIBITORS OF MEK
  申请人：MADERNA Andreas

  公开号：US20120022076A1

  公开（公告）日：2012-01-26

  This invention concerns N-(2-arylamino)aryl sulfonamides, which are inhibitors of MEK and are useful in treatment of cancer and other hyperproliferative diseases.

  这项发明涉及N-(2-芳基氨基)芳基磺酰胺，它们是MEK的抑制剂，并且在治疗癌症和其他过度增殖性疾病方面非常有用。
• Compositions and methods for preparing and using same
  申请人：Quart Barry D.

  公开号：US08808742B2

  公开（公告）日：2014-08-19

  This invention relates to compositions, methods for preparing the compositions and methods for treating or preventing diseases, comprising administering the compositions.

  本发明涉及组合物、制备组合物的方法以及治疗或预防疾病的方法，包括给予该组合物。
• Derivatives of N-(arylamino)sulfonamides as inhibitors of MEK
  申请人：Maderna Andreas

  公开号：US08829052B2

  公开（公告）日：2014-09-09

  This invention concerns N-(2-arylamino)aryl sulfonamides, which are inhibitors of MEK and are useful in treatment of cancer and other hyperproliferative diseases.

  这项发明涉及N-(2-芳基氨基)芳基磺酰胺，它们是MEK的抑制剂，并且在癌症和其他增殖性疾病的治疗中有用。