(Z)-1-(2,3-二氟-6-甲氧基苯基)-N-羟基甲亚胺 | 221202-32-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 中文名称: (Z)-1-(2,3-二氟-6-甲氧基苯基)-N-羟基甲亚胺
• 英文名称: N-[(2,3-Difluoro-6-methoxyphenyl)methylidene]hydroxylamine
• CAS: 221202-32-0
• 化学式: C₈H₇F₂NO₂
• 分子量: 187.14
• InChiKey: YEWUKOUGKSQVEP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  41.8
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2,3-二氟-6-甲氧基苯甲醛 、 盐酸羟胺 、 sodium acetate 在 甲醇 作用下， 以 甲醇 为溶剂， 反应 16.0h， 以giving 28.3 g of the desired product of m.p. 199-201° C.的产率得到(Z)-1-(2,3-二氟-6-甲氧基苯基)-N-羟基甲亚胺
  参考文献：
  名称：

  Benzamidoxime derivatives, intermediates and processes for their preparation, and their use as fungicides

  摘要：

  公式I中的Benzamidoxime衍生物：其中R1为二氟甲基或三氟甲基，R2为氢或氟，R3为C1-C4烷基，可以被氰基，C1-C4卤代烷基，C1-C4烷氧基-C1-C4烷基，C3-C6烯基，C3-C6卤代烯基，C3-C6炔基，C3-C8环烷基-C1-C4烷基取代，R4为苯基-C1-C6烷基，可以在苯环上携带一个或多个取代基，所述取代基从卤素，C1-C4烷基，C1-C4卤代烷基，C1-C4烷氧基和C1-C4卤代烷氧基的群中选择，或者为噻吩基-C1-C4烷基，可以在噻吩环上携带一个或多个取代基，所述取代基从卤素，C1-C4烷基，C1-C4卤代烷基，C1-C4烷氧基和C1-C4卤代烷氧基的群中选择，或者为吡唑基-C1-C4烷基，可以在吡唑环上携带一个或多个取代基，所述取代基从卤素，C1-C4烷基，C1-C4卤代烷基，C1-C4烷氧基和C1-C4卤代烷氧基的群中选择。本文描述了它们的制备方法和中间体，以及它们作为杀菌剂的用途。

  公开号：

  US06680402B2

文献信息

• Novel benzamidoxime derivatives, intermediates and processes for their preparation, and their use as fungicides
  申请人：——

  公开号：US20030120085A1

  公开（公告）日：2003-06-26

  Benzamidoxime derivatives of the formula I 1 where R 1 is difluoromethyl or trifluoromethyl R 2 is hydrogen or fluorine R 3 is C 1 -C 4 -alkyl which may be substituted by cyano, C 1 -C 4 -haloalkyl, C 1 -C 4 -alkoxy-C 1 -C 4 -alkyl, C 3 -C 6 -alkenyl, C 3 -C 6 -haloalkenyl, C 3 -C 6 -alkynyl, C 3 -C 8 -cycloalkyl-C 1 -C 4 -alkyl R 4 is phenyl-C 1 -C 6 -alkyl which may carry one or more substitutents selected from the group consisting of halogen, C 1 -C 4 -alkyl, C 1 -C 4 -haloalkyl, C 1 -C 4 -alkoxy and C 1 -C 4 -haloalkoxy on the phenyl ring, or is thienyl-C 1 -C 4 -alkyl which may carry one or more substituents selected from the group consisting of halogen, C 1 -C 4 -alkyl, C 1 -C 4 -haloalkyl, C 1 -C 4 -alkoxy and C 1 -C 4 -haloalkoxy on the thienyl ring, or is pyrazolyl-C 1 -C 4 -alkyl which may carry one or more substituents selected from the group consisting of halogen, C 1 -C 4 -alkyl, C 1 -C 4 -haloalkyl, C 1 -C 4 -alkoxy and C 1 -C 4 -haloalkoxy on the pyrazole ring, are prepared, and intermediates for their preparation and their use as fungicides are described.

  本发明涉及一种Benzamidoxime衍生物，其化学式为I1，其中：R1为二氟甲基或三氟甲基；R2为氢或氟；R3为C1-C4烷基，该烷基可以被氰基、C1-C4卤代烷基、C1-C4烷氧基-C1-C4烷基、C3-C6烯基、C3-C6卤代烯基、C3-C6炔基、C3-C8环烷基-C1-C4烷基所取代；R4为苯基-C1-C6烷基，该苯基可以在苯环上携带一个或多个卤素、C1-C4烷基、C1-C4卤代烷基、C1-C4烷氧基和C1-C4卤代烷氧基中的一种或多种取代基，或为噻吩基-C1-C4烷基，该噻吩基可以在噻吩环上携带一个或多个卤素、C1-C4烷基、C1-C4卤代烷基、C1-C4烷氧基和C1-C4卤代烷氧基中的一种或多种取代基，或为吡唑基-C1-C4烷基，该吡唑基可以在吡唑环上携带一个或多个卤素、C1-C4烷基、C1-C4卤代烷基、C1-C4烷氧基和C1-C4卤代烷氧基中的一种或多种取代基。本发明还涉及制备这些化合物的中间体以及它们作为杀真菌剂的用途。
• Benzamidoxim derivatives, intermediate products and methods for preparing and using them as fungicides
  申请人：BASF Aktiengesellschaft

  公开号：US06420605B1

  公开（公告）日：2002-07-16

  The invention relates to benzamidoxim derivatives of formula (I) wherein the substituents have the following meanings: R1 represents difluoromethyl or trifluoromethyl, R2 represents hydrogen or fluorine, R3 represents C1-C4 alkyl optionally substituted with cyano, C1-C4 halogenalkyl, C1-C4 alkoxy-C1-C4 alkyl, C3-C6 alkenyl, C3-C6 halogenalkenyl, C3-C6 alkinyl, C3-C8 cycloalkyl-C1-C4 alkyl, R4 represents phenyl-C1-C6 alkyl, which can carry one or more substituents selected from the group composed of halogen, C1-C4 alkyl, C1-C4 halogenalkyl, C1-C4 alkoxy or C1-C4 halogenalkoxy on the phenyl ring, or thienyl-C1-C4 alkyl, which can carry one or more substituents selected from the group composed of halogen, C1-C4 alkyl, C1-C4 halogenalkyl, C1-C4 halogenalkoxy on the thienyl ring, or pyrazol-C1-C4 alkyl, which can carry one or more substituents selected from the group composed of halogen, C1-C4 alkyl, C1-C4 halogenalkyl, C1-C4 alkoxy or C1-C4 halogenalkoxy on the pyrazol ring. The invention also relates to intermediate products for the preparation of these derivatives and to their use as fungicides.

  本发明涉及式（I）的苯甲酰肟衍生物，其中取代基具有以下含义：R1代表二氟甲基或三氟甲基，R2代表氢或氟，R3代表C1-C4烷基，可选择地取代氰基，C1-C4卤代烷基，C1-C4烷氧基-C1-C4烷基，C3-C6烯基，C3-C6卤代烯基，C3-C6炔基，C3-C8环烷基-C1-C4烷基，R4代表苯基-C1-C6烷基，其可以在苯环上携带来自卤素，C1-C4烷基，C1-C4卤代烷基，C1-C4烷氧基或C1-C4卤代烷氧基的一个或多个取代基，或噻吩基-C1-C4烷基，其可以在噻吩环上携带来自卤素，C1-C4烷基，C1-C4卤代烷基，C1-C4卤代烷氧基的一个或多个取代基，或吡唑基-C1-C4烷基，其可以在吡唑环上携带来自卤素，C1-C4烷基，C1-C4卤代烷基，C1-C4烷氧基或C1-C4卤代烷氧基的一个或多个取代基。本发明还涉及制备这些衍生物的中间体和它们作为杀真菌剂的用途。
• Benzamidoxime derivatives, intermediates and processes for their preparation, and their use as fungicides
  申请人：BASF Aktiengesellschaft

  公开号：US06680402B2

  公开（公告）日：2004-01-20

  Benzamidoxime derivatives of the formula I: where R1 is difluoromethyl or trifluoromethyl R2 is hydrogen or fluorine R3 is C1-C4-alkyl which may be substituted by cyano, C1-C4-haloalkyl, C1-C4-alkoxy-C1-C4-alkyl, C3-C6-alkenyl, C3-C6-haloalkenyl, C3-C6-alkynyl, C3-C8-cycloalkyl-C1-C4-alkyl R4 is phenyl-C1-C6-alkyl which may carry one or more substitutents selected from the group consisting of halogen, C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-alkoxy and C1-C4-haloalkoxy on the phenyl ring, or is thienyl-C1-C4-alkyl which may carry one or more substituents selected from the group consisting of halogen, C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-alkoxy and C1-C4-haloalkoxy on the thienyl ring, or is pyrazolyl-C1-C4-alkyl which may carry one or more substituents selected from the group consisting of halogen, C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-alkoxy and C1-C4-haloalkoxy on the pyrazole ring, are prepared, and intermediates for their preparation and their use as fungicides are described.

  公式I中的Benzamidoxime衍生物：其中R1为二氟甲基或三氟甲基，R2为氢或氟，R3为C1-C4烷基，可以被氰基，C1-C4卤代烷基，C1-C4烷氧基-C1-C4烷基，C3-C6烯基，C3-C6卤代烯基，C3-C6炔基，C3-C8环烷基-C1-C4烷基取代，R4为苯基-C1-C6烷基，可以在苯环上携带一个或多个取代基，所述取代基从卤素，C1-C4烷基，C1-C4卤代烷基，C1-C4烷氧基和C1-C4卤代烷氧基的群中选择，或者为噻吩基-C1-C4烷基，可以在噻吩环上携带一个或多个取代基，所述取代基从卤素，C1-C4烷基，C1-C4卤代烷基，C1-C4烷氧基和C1-C4卤代烷氧基的群中选择，或者为吡唑基-C1-C4烷基，可以在吡唑环上携带一个或多个取代基，所述取代基从卤素，C1-C4烷基，C1-C4卤代烷基，C1-C4烷氧基和C1-C4卤代烷氧基的群中选择。本文描述了它们的制备方法和中间体，以及它们作为杀菌剂的用途。