7-cyclopropyl-2-phenyl-4H-pyrido[1,2-a]pyrimidin-4-one | 1338923-05-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 7-cyclopropyl-2-phenyl-4H-pyrido[1,2-a]pyrimidin-4-one
• 英文别名: 7-Cyclopropyl-2-phenylpyrido[1,2-a]pyrimidin-4-one
• CAS: 1338923-05-9
• 化学式: C₁₇H₁₄N₂O
• 分子量: 262.311
• InChiKey: PXMWWKJXVVELBL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  32.7
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  7-bromo-2-phenyl-4H-pyrido[1,2-a]pyrimidin-4-one 、 环丙基硼酸 在 potassium phosphate 、 palladium diacetate 、 三环己基膦 作用下， 以 水 、 甲苯 为溶剂， 反应 3.0h， 生成 7-cyclopropyl-2-phenyl-4H-pyrido[1,2-a]pyrimidin-4-one
  参考文献：
  名称：

  Identification of Pyrido[1,2-α]pyrimidine-4-ones as New Molecules Improving the Transcriptional Functions of Estrogen-Related Receptor α

  摘要：

  The nuclear estrogen-related receptor alpha (ERR alpha) plays a central role in the regulation of expression of the genes involved in mitochondrial biogenesis and oxidative metabolism. We have successfully identified a series of pyrido [1,2-alpha]pyrimidin-4-ones as new agonists enhancing the transcriptional functions of ERRa. The compounds potently elevated the m RNA levels and the protein levels of ERRa downstream targets. Consequently, the compounds improved the glucose and fatty acid uptake in C2C12 muscle cells.

  DOI：

  10.1021/jm200976s

文献信息

• Identification of Pyrido[1,2-α]pyrimidine-4-ones as New Molecules Improving the Transcriptional Functions of Estrogen-Related Receptor α
  作者：Lijie Peng、Xuefei Gao、Lei Duan、Xiaomei Ren、Donghai Wu、Ke Ding

  DOI：10.1021/jm200976s

  日期：2011.11.10

  The nuclear estrogen-related receptor alpha (ERR alpha) plays a central role in the regulation of expression of the genes involved in mitochondrial biogenesis and oxidative metabolism. We have successfully identified a series of pyrido [1,2-alpha]pyrimidin-4-ones as new agonists enhancing the transcriptional functions of ERRa. The compounds potently elevated the m RNA levels and the protein levels of ERRa downstream targets. Consequently, the compounds improved the glucose and fatty acid uptake in C2C12 muscle cells.