methyl (2S)-1-chlorosulfonylpiperidine-2-carboxylate | 343616-26-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: methyl (2S)-1-chlorosulfonylpiperidine-2-carboxylate
• CAS: 343616-26-2
• 化学式: C₇H₁₂ClNO₄S
• 分子量: 241.696
• InChiKey: JNRDRJWDMLSDQQ-LURJTMIESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  72.1
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  methyl (2S)-1-chlorosulfonylpiperidine-2-carboxylate 在 吡啶 、 苯胺-15N 作用下， 生成
  参考文献：
  名称：

  An efficient synthesis of sulfamides

  摘要：

  Here we report an efficient synthesis of sulfamides. 3,5-Lutidine was found to be an optimal solvent and catalyst for the reaction. The method was developed during our efforts to synthesize a series of novel FKBP-12 inhibitors in which the known ketoamide linker was replaced with sulfamide. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.03.106
• 作为产物：
  描述：

  在 五氯化磷 作用下， 以 苯 为溶剂， 生成 methyl (2S)-1-chlorosulfonylpiperidine-2-carboxylate
  参考文献：
  名称：

  An efficient synthesis of sulfamides

  摘要：

  Here we report an efficient synthesis of sulfamides. 3,5-Lutidine was found to be an optimal solvent and catalyst for the reaction. The method was developed during our efforts to synthesize a series of novel FKBP-12 inhibitors in which the known ketoamide linker was replaced with sulfamide. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.03.106

文献信息

• An efficient synthesis of sulfamides
  作者：Chuangxing Guo、Liming Dong、Susan Kephart、Xinjun Hou

  DOI：10.1016/j.tetlet.2010.03.106

  日期：2010.5

  Here we report an efficient synthesis of sulfamides. 3,5-Lutidine was found to be an optimal solvent and catalyst for the reaction. The method was developed during our efforts to synthesize a series of novel FKBP-12 inhibitors in which the known ketoamide linker was replaced with sulfamide. (C) 2010 Elsevier Ltd. All rights reserved.