4-hydroxy-2-methyl-n-(pyridin-2-yl)-6-trifluoromethyl-2H-thieno[2,3-e]-1,2-thiazine-3-carboxamide 1,1-dioxide | 90908-34-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 4-hydroxy-2-methyl-n-(pyridin-2-yl)-6-trifluoromethyl-2H-thieno[2,3-e]-1,2-thiazine-3-carboxamide 1,1-dioxide
• 英文别名: 4-hydroxy-2-methyl-n-(2-pyridyl)-6-trifluoromethyl-2H-thieno[2,3-e]-1,2-thiazine-3-carboxamide 1,1-dioxide；2H-Thieno(2,3-e)-1,2-thiazine-3-carboxamide, 4-hydroxy-2-methyl-N-2-pyridinyl-6-trifluoromethyl-, 1,1-dioxide；4-hydroxy-2-methyl-1,1-dioxo-N-pyridin-2-yl-6-(trifluoromethyl)thieno[2,3-e]thiazine-3-carboxamide
• CAS: 90908-34-2
• 化学式: C₁₄H₁₀F₃N₃O₄S₂
• 分子量: 405.378
• InChiKey: FHZDNBBQTQLLLV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  26
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  136
• 氢给体数：
  2
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  2-氨基吡啶 、 4-hydroxy-2-methyl-6-(trifluoromethyl)-2H-thieno[2,3-e]-1,2-thiazine-3-carboxylic acid methylester-1,1-dioxide 、 甲烷 生成 4-hydroxy-2-methyl-n-(pyridin-2-yl)-6-trifluoromethyl-2H-thieno[2,3-e]-1,2-thiazine-3-carboxamide 1,1-dioxide 、 4-hydroxy-2-methyl-3-(2-pyridylcarbamoyl)-6-trifluoromethyl-2H-thienol[2,3,e]-1,2-thiazine 1,1 dioxide
  参考文献：
  名称：

  摘要：

  DOI：

文献信息

• Thieno(2,3-e)-1,2-thiazin-Derivate
  申请人：F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft

  公开号：EP0103142B1

  公开（公告）日：1987-04-22
• Use of Oxicam Compounds
  申请人：Binder Dieter

  公开号：US20070275958A1

  公开（公告）日：2007-11-29

  The invention relates to the use of lornoxicam or analogues thereof which inhibit cyclo-oxygenase 1 and cyclo-oxygenase 2 (COX 1 and COX 2), cannot penetrate the blood-brain barrier under physiological conditions, and reduce the prostaglandin E2-induced induction of the amyloid-precursor-protein (APP), for producing a pharmaceutical composition for the treatment or prevention of Alzheimer's disease or arteriosclerosis.
• USE OF OXICAM COMPOUNDS
  申请人：Binder Dieter

  公开号：US20090239852A1

  公开（公告）日：2009-09-24

  Methods of treating and/or preventing arteriosclerosis are disclosed. In certain methods, a composition containing at least one lornoxicam or lornoxicam analogue that inhibits cyclooxygenase 1 and cyclooxygenase 2 (COX 1 and COX 2), cannot cross the blood/brain barrier under physiological conditions, and reduces the prostaglandin E2-induced induction of the amyloid precursor protein (APP) is administered to a subject to treat and/or prevent arteriosclerosis in the subject.
• US4544655A
  申请人：——

  公开号：US4544655A

  公开（公告）日：1985-10-01
• US8129370B2
  申请人：——

  公开号：US8129370B2

  公开（公告）日：2012-03-06