2-Hydroxy-6-(8-hydroxyoctyl)benzoic acid | 1082424-10-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Hydroxy-6-(8-hydroxyoctyl)benzoic acid
• CAS: 1082424-10-9
• 化学式: C₁₅H₂₂O₄
• 分子量: 266.337
• InChiKey: ILIGLITWSLPRMR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  19
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  77.8
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  Ethyl 2-hydroxy-6-(8-hydroxyoctyl)benzoate 在 sodium hydroxide 作用下， 以 二甲基亚砜 为溶剂， 反应 5.0h， 以18.1 mg的产率得到2-Hydroxy-6-(8-hydroxyoctyl)benzoic acid
  参考文献：
  名称：

  Anacardic acid derivatives as inhibitors of glyceraldehyde-3-phosphate dehydrogenase from Trypanosoma cruzi

  摘要：

  Chagas' disease, a parasitic infection caused by the flagellate protozoan Trypanosoma cruzi, is a major public health problem affecting millions of individuals in Latin America. On the basis of the essential role in the life cycle of T. cruzi, the glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPDH) has been considered an attractive target for the development of novel antitrypanosomatid agents. In the present work, we describe the inhibitory effects of a small library of natural and synthetic anacardic acid derivatives against the target enzyme. The most potent inhibitors, 6-n-pentadecyl-(1) and 6-n-dodecylsalicilic acids (10e), have IC50 values of 28 and 55 mu M, respectively. The inhibition was not reversed or prevented by the addition of Triton X-100, indicating that aggregate-based inhibition did not occur. In addition, detailed mechanistic characterization of the effects of these compounds on the T. cruzi GAPDH-catalyzed reaction showed clear noncompetitive inhibition with respect to both substrate and cofactor. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2008.08.057

文献信息

• Use of salicylic acid derivatives as prodesquamating active agent
  申请人：L'OREAL

  公开号：US11179306B2

  公开（公告）日：2021-11-23

  Cosmetic use of at least one salicylic acid derivative of following formula (I) in which L represents a linear or branched hydrocarbon radical comprising from 1 to 12 carbon atoms and having or not having one or more ethylenic unsaturations, and X represents a radical chosen from —OH and —CO2H, and also its cosmetically acceptable salts, its solvates, such as its hydrates, and its isomers, in a composition comprising a physiologically acceptable medium, as cosmetic agent intended to promote the desquamation of the skin and/or to stimulate epidermal renewal.

  至少一种水杨酸衍生物的化妆品用途，如下式（I），其中 L 代表线性或支链烃基，包含 1 至 12 个碳原子，具有或不具有一个或多个乙烯不饱和基，X 代表选自-OH 和-CO2H 的基，以及其化妆品可接受的盐、溶液剂（如水合物）和异构体，在包含生理上可接受的介质的组合物中，用作旨在促进皮肤脱屑和/或刺激表皮更新的化妆品剂。
• [EN] USE OF SALICYLIC ACID DERIVATIVES AS PRODESQUAMATING ACTIVE AGENT<br/>[FR] UTILISATION DE DÉRIVÉS D'ACIDE SALICYLIQUE À TITRE D'AGENTS ACTIFS DE PRO-DESQUAMATION
  申请人：OREAL

  公开号：WO2015097585A3

  公开（公告）日：2015-10-22
• FRACTIONATION OF CASHEW NUT SHELL LIQUID
  申请人：Bangor University

  公开号：EP2566596A2

  公开（公告）日：2013-03-13
• USE OF SALICYLIC ACID DERIVATIVES AS PRODESQUAMATING ACTIVE AGENT
  申请人：L'OREAL

  公开号：EP3086765B1

  公开（公告）日：2021-07-28
• [EN] FRACTIONATION OF CASHEW NUT SHELL LIQUID<br/>[FR] FRACTIONNEMENT DE BAUME DE CAJOU
  申请人：UNIV BANGOR

  公开号：WO2011138608A2

  公开（公告）日：2011-11-10

  A method for the fractionation of cashew nut shell liquid comprises solvent-solvent extraction using a polar solvent component and a non-polar, non-acidic, non-basic solvent component; wherein the polar solvent component is a mixture comprising: i) a first solvent comprising a fluorinated solvent; and ii) a second solvent comprising a solvent satisfying the following parameters: a) Hildebrand parameter greater than 10 (kcal dnT-3)0,5 and b) dipolarity/polarizability (π), hydrogen bond acidity (a), and hydrogen bond basicity (β) having the following relationship: α/(α + β + π) > 0.5; β/(α + β + π) < 0.8; and π /(α + β + π) > 0.3.