6-(8-formylheptyl)-2-hydroxybenzoic acid | 468081-25-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 6-(8-formylheptyl)-2-hydroxybenzoic acid
• 英文别名: 8-(2-carboxy-3-hydroxyphenyl)octanal；2-Hydroxy-6-(8-oxooctyl)benzoic acid
• CAS: 468081-25-6
• 化学式: C₁₅H₂₀O₄
• 分子量: 264.321
• InChiKey: HFSHHMTXTVRIBB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  19
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  6-(8-formylheptyl)-2-hydroxybenzoic acid 在 甲醇 、 sodium tetrahydroborate 作用下， 反应 2.0h， 以0.42 g的产率得到2-Hydroxy-6-(8-hydroxyoctyl)benzoic acid
  参考文献：
  名称：

  [EN] USE OF SALICYLIC ACID DERIVATIVES AS PRODESQUAMATING ACTIVE AGENT
  [FR] UTILISATION DE DÉRIVÉS D'ACIDE SALICYLIQUE À TITRE D'AGENTS ACTIFS DE PRO-DESQUAMATION

  摘要：

  公开号：

  WO2015097585A3

文献信息

• Use of salicylic acid derivatives as prodesquamating active agent
  申请人：L'OREAL

  公开号：US11179306B2

  公开（公告）日：2021-11-23

  Cosmetic use of at least one salicylic acid derivative of following formula (I) in which L represents a linear or branched hydrocarbon radical comprising from 1 to 12 carbon atoms and having or not having one or more ethylenic unsaturations, and X represents a radical chosen from —OH and —CO2H, and also its cosmetically acceptable salts, its solvates, such as its hydrates, and its isomers, in a composition comprising a physiologically acceptable medium, as cosmetic agent intended to promote the desquamation of the skin and/or to stimulate epidermal renewal.

  至少一种水杨酸衍生物的化妆品用途，如下式（I），其中 L 代表线性或支链烃基，包含 1 至 12 个碳原子，具有或不具有一个或多个乙烯不饱和基，X 代表选自-OH 和-CO2H 的基，以及其化妆品可接受的盐、溶液剂（如水合物）和异构体，在包含生理上可接受的介质的组合物中，用作旨在促进皮肤脱屑和/或刺激表皮更新的化妆品剂。
• Synthesis of isonicotinoylhydrazones from anacardic acid and their in vitro activity against Mycobacterium smegmatis
  作者：B. Narayana Swamy、T.K. Suma、G. Venkateswara Rao、G. Chandrasekara Reddy

  DOI：10.1016/j.ejmech.2006.09.009

  日期：2007.3

  Isonicotinoylhydrazones were synthesized from a natural product anacardic acid, a major constituent of cashew nut shell liquid. The unsaturated side chain in anacardic acid and its 5-nitro derivative were converted into C-8'-aldehydes by oxidative cleavage. C-8'-aldehydes are then coupled with isoniazid (an anti-TB drug) to obtain N-isonicotinoyl-N'-8-[(2'-carbohydroxy-3'-hydroxy) phenyl] octanal hydrazone (5) and N-isonicotinoyl-N'-8-[(2'-carbohydroxy-3'-hydroxy-6-nitro) phenyl] octanal hydrazone (6). These isonicotmoylhydrazones of anacardic aldehydes showed potent antimycobacterial activity against Mycobacterium smegmatis mc(2) 155. The synergistic studies of 5 and 6 with isoniazid showed more inhibitory activities than isoniazid alone. Compounds 5 and 6 also showed activity against Mycobacterium tuberculosis H(37)Rv. (c) 2006 Elsevier Masson SAS. All rights reserved.
• USE OF SALICYLIC ACID DERIVATIVES AS PRODESQUAMATING ACTIVE AGENT
  申请人：L'OREAL

  公开号：US20160331660A1

  公开（公告）日：2016-11-17

  Cosmetic use of at least one salicylic acid derivative of following formula (I) in which L represents a linear or branched hydrocarbon radical comprising from 1 to 12 carbon atoms and having or not having one or more ethylenic unsaturations, and X represents a radical chosen from —OH and —CO 2 H, and also its cosmetically acceptable salts, its solvates, such as its hydrates, and its isomers, in a composition comprising a physiologically acceptable medium, as cosmetic agent intended to promote the desquamation of the skin and/or to stimulate epidermal renewal.
• [EN] USE OF SALICYLIC ACID DERIVATIVES AS PRODESQUAMATING ACTIVE AGENT<br/>[FR] UTILISATION DE DÉRIVÉS D'ACIDE SALICYLIQUE À TITRE D'AGENTS ACTIFS DE PRO-DESQUAMATION
  申请人：OREAL

  公开号：WO2015097585A3

  公开（公告）日：2015-10-22