miyakosyne A | 1312225-41-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: miyakosyne A
• 英文别名: (3R,4E,24E,26R)-14-methyloctacosa-4,24-dien-1,27-diyne-3,26-diol
• CAS: 1312225-41-4
• 化学式: C₂₉H₄₈O₂
• 分子量: 428.699
• InChiKey: VAEFGKZDLREYOM-AYHLBKKOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10
• 重原子数：
  31
• 可旋转键数：
  21
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.72
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  miyakosyne A 、 甲氧基-三氟甲基苯 在 吡啶 作用下， 反应 4.0h， 生成
  参考文献：
  名称：

  Miyakosynes A–F, cytotoxic methyl branched acetylenes from a marine sponge Petrosia sp.

  摘要：

  Cytototoxic linear acetylenes, miyakosynes A-F, were isolated from a marine sponge Petrosia sp. Their structures were elucidated by a combination of spectroscopic analyses and chemical methods. The absolute configuration of the secondary alcohols at each terminus was determined by the modified Mosher's analysis. Miyakosynes show cytotoxicity against HeLa cells at submicromolar concentrations. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2011.04.085

文献信息

• Miyakosynes A–F, cytotoxic methyl branched acetylenes from a marine sponge Petrosia sp.
  作者：Yuki Hitora、Kentaro Takada、Shigeru Okada、Shigeki Matsunaga

  DOI：10.1016/j.tet.2011.04.085

  日期：2011.6

  Cytototoxic linear acetylenes, miyakosynes A-F, were isolated from a marine sponge Petrosia sp. Their structures were elucidated by a combination of spectroscopic analyses and chemical methods. The absolute configuration of the secondary alcohols at each terminus was determined by the modified Mosher's analysis. Miyakosynes show cytotoxicity against HeLa cells at submicromolar concentrations. (C) 2011 Elsevier Ltd. All rights reserved.