Methyl 2-[[5-(aminomethyl)-4-(2,4-difluorophenyl)-6-methylpyridine-2-carbonyl]amino]acetate | 1253518-60-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Methyl 2-[[5-(aminomethyl)-4-(2,4-difluorophenyl)-6-methylpyridine-2-carbonyl]amino]acetate
• CAS: 1253518-60-3
• 化学式: C₁₇H₁₇F₂N₃O₃
• 分子量: 349.337
• InChiKey: XZNIUQDMIJFEES-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  94.3
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  5-(aminomethyl)-4-(2,4-difluorophenyl)-6-methyl-N-(5-methylisoxazol-3-yl)picolinamide 在 benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate 、 水 、 三乙胺 、 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 生成 Methyl 2-[[5-(aminomethyl)-4-(2,4-difluorophenyl)-6-methylpyridine-2-carbonyl]amino]acetate
  参考文献：
  名称：

  Design, Synthesis, and in Vitro Evaluation of Novel Aminomethyl-pyridines as DPP-4 Inhibitors

  摘要：

  A collection of novel aminomethyl-pyridines was designed, synthesized, and investigated as potential inhibitors of DPP-4. Optimization of the screening hit afforded a number of 5-aminomethyl-pyridines with inhibitory activity in the nanomolar range. Selected DPP-4 inhibitors were further evaluated for their selectivity over the closely related peptidase DPP-8. 5-Aminomethyl-4-(2,4-dichlorophenyl)-6-methyl-pyridine-2-carboxylic acid cyanomethyl-amide showed high potency and excellent DPP-4 selectivity [IC50: 10 (DPP-4) and 6600 nM (DPP-8)] and no toxicity in mammalian cell culture.

  DOI：

  10.1021/ml100200c

文献信息

• Design, Synthesis, and in Vitro Evaluation of Novel Aminomethyl-pyridines as DPP-4 Inhibitors
  作者：Katarzyna Kaczanowska、Karl-Heinz Wiesmüller、Arnaud-Pierre Schaffner

  DOI：10.1021/ml100200c

  日期：2010.12.9

  A collection of novel aminomethyl-pyridines was designed, synthesized, and investigated as potential inhibitors of DPP-4. Optimization of the screening hit afforded a number of 5-aminomethyl-pyridines with inhibitory activity in the nanomolar range. Selected DPP-4 inhibitors were further evaluated for their selectivity over the closely related peptidase DPP-8. 5-Aminomethyl-4-(2,4-dichlorophenyl)-6-methyl-pyridine-2-carboxylic acid cyanomethyl-amide showed high potency and excellent DPP-4 selectivity [IC50: 10 (DPP-4) and 6600 nM (DPP-8)] and no toxicity in mammalian cell culture.