4-(3-氟-4-羟苯基)苯酚 | 885473-84-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4-(3-氟-4-羟苯基)苯酚
• 英文名称: 3'-Fluoro-4,4'-dihydroxy-biphenyl
• 英文别名: 3-fluoro[1,1'-biphenyl]-4,4'-diol；3-fluorobiphenyl-4,4'-diol；3-Fluoro-[1,1'-biphenyl]-4,4'-diol；2-fluoro-4-(4-hydroxyphenyl)phenol
• CAS: 885473-84-7
• 化学式: C₁₂H₉FO₂
• 分子量: 204.201
• InChiKey: QVQNAAFDYYJACI-UHFFFAOYSA-N

物化性质

• 沸点：
  339.6±27.0 °C(Predicted)
• 密度：
  1.310±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-(3-氟-4-羟苯基)苯酚 、 (6-bromohexyloxy)methyl-15-crown-5 在 sodium hydroxide 作用下， 以 四氢呋喃 为溶剂， 生成 2-Fluoro-4-[4-[6-(1,4,7,10,13-pentaoxacyclopentadec-2-ylmethoxy)hexoxy]phenyl]phenol
  参考文献：
  名称：

  Reactive mesogen and liquid crystal composition including the same

  摘要：

  提供了一种反应性介质，可改善液晶显示器的显示质量，以及包括该反应性介质的液晶组合物。该反应性介质由以下公式表示：其中，A1、A2和A3分别独立地表示取代或未取代的双价碳氢环或取代或未取代的双价杂环，L1和L2分别独立地表示直接连接、-O-、-S-、-CO-、-COO-、-OCOO-、-O(CH2)k1-、-S(CH2)k1-、-O(CF2)k1-、-S(CF2)k1-、-(CH2)k1-、-CF2CH2-、-(CF2)k1-、-CH═CH-、-CF═CF-、-C≡C-、-CH═CH-COO-或-(CH2)k1-COO-(CH2)k2-O-，Z1和Z2分别独立地表示直接连接、-O-、-S-、-CO-、-COO-、-OCOO-、-O(CH2)m1-、-S(CH2)m1-、-O(CF2)m1-、-S(CF2)m1-、-(CH2)m1-、-CF2CH2-、-(CF2)m1-、-CH═CH-、-CF═CF-、-C≡C-、-CH═CH-COO-、-(CH2)m1-COO-或-(CH2)m1-COO-(CH2)m2-O-，Pa是一种可聚合的基团，B是一个未取代的杂环、取代或未取代的冠醚基团，或其中T1和T2分别独立地表示-OH、-CH3、-CF3、-CHF2、-CH2F、-CH2Br、-CHBr2、-CHCl2或-CH2Cl。

  公开号：

  US10344213B2

文献信息

• Antibacterial macrocycles with substituted biphenyl
  申请人：Endermann Rainer

  公开号：US20070099885A1

  公开（公告）日：2007-05-03

  The invention relates to antibacterial macrocycles with substituted biphenyl and processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the production of medicaments for the treatment and/or prophylaxis of diseases, especially of bacterial infections.

  这项发明涉及具有取代联苯基的抗菌大环化合物，以及它们的制备方法，它们用于治疗和/或预防疾病，以及它们用于生产用于治疗和/或预防疾病的药物，特别是细菌感染。
• [EN] SUBSTITUTED PIPERIDINE DERIVATIVES AND METHODS FOR PREPARING THE SAME<br/>[FR] DÉRIVÉS DE PIPÉRIDINE SUBSTITUÉE ET PROCÉDÉS POUR LES PRÉPARER
  申请人：HYUNDAI PHARM CO LTD

  公开号：WO2013105753A1

  公开（公告）日：2013-07-18

  The present invention relates to a novel compound or a pharmaceutically acceptable salt thereof, a preparation method thereof and a pharmaceutical composition for treating metabolism-related disorder containing the same. Specifically, the present invention relates to a compound of the formula 1, which can activate GPR119 to treat metabolism-related disorders, including diabetes and related diseases, diabetes-related microvascular complications, diabetes-related macrovascular complications, cardiovascular abnormalities, metabolic syndrome and its constituent diseases, and obesity.

  本发明涉及一种新颖化合物或其药用可接受盐，以及其制备方法和含有该化合物的用于治疗与代谢相关疾病的药物组合物。具体而言，本发明涉及一种符合式1的化合物，可以激活GPR119以治疗与代谢相关的疾病，包括糖尿病及相关疾病、糖尿病相关微血管并发症、糖尿病相关大血管并发症、心血管异常、代谢综合征及其组成疾病以及肥胖症。
• POLYMERIZABLE COMPOUND, AND LIQUID CRYSTAL COMPOSITION PRODUCED USING SAME
  申请人：DIC CORPORATION

  公开号：US20160137921A1

  公开（公告）日：2016-05-19

  The polymerizable composition and the liquid crystal composition containing the polymerizable compound of the present invention have favorable storage stability as evaluated on the basis of the occurrence of precipitation, separation, or the like of crystals during storage. The present invention relates to a polymerizable compound, a liquid crystal composition which contains the compound, and further a liquid crystal display element which contains an optically anisotropic material which is a cured product of the liquid crystal composition, or a cured product which controls alignment of liquid crystal molecules. That is, the present invention relates to a polymerizable compound, and a liquid crystal composition containing the polymerizable compound which contains the polymerizable compound and a liquid crystal compound. The polymerizable compound is a compound represented by General Formula (I), and is useful for an optically anisotropic material, a retardation layer, an alignment film, or a polarizing layer.

  本发明的可聚合组合物和含有该可聚合化合物的液晶组合物在存储期间的晶体沉淀、分离等方面具有良好的稳定性。本发明涉及一种可聚合化合物、包含该化合物的液晶组合物以及进一步包含液晶组合物的光学各向异性材料的固化产物的液晶显示元件，或控制液晶分子取向的固化产物。也就是说，本发明涉及一种可聚合化合物和包含该可聚合化合物的液晶组合物，该可聚合化合物是由通式（I）表示的化合物，可用于光学各向异性材料、减速层、取向膜或偏振层。
• POLYMERIZABLE COMPOUND HAVING METHOXYMETHYL ACRYLIC GROUP, LIQUID CRYSTAL COMPOSITION, AND LIQUID CRYSTAL DISPLAY DEVICE
  申请人：JNC Corporation

  公开号：EP3725764A1

  公开（公告）日：2020-10-21

  The problem is to provide a polymerizable compound having suitable polymerization reactivity, a high conversion ratio, low polymerization starting temperature, and high solubility in a liquid crystal composition; a liquid crystal composition containing the compound; and a liquid crystal display device including the composition. A means thereof includes a compound represented by formula (1) and a liquid crystal composition containing the compound. In formula (1), R1, R2 and R3 are independently alkyl or the like; n is 0 or the like; ring A1 is phenyl or the like, and ring A2 and ring A3 are independently 1,4-phenylene or the like; Z1 and Z2 are independently a single bond or the like; Sp1 to Sp4 are a single bond or the like; a is 1 or the like; c, d and e are independently 0 or 1, and a sum of c, d and e is 1 or the like; and P1 to P4 are a polymerizable group, and at least one of P1 to P4 is a polymerizable group represented by formula (P-1).

  问题在于提供一种在液晶组合物中具有合适的聚合反应活性、高转化率、低聚合起始温度和高溶解度的可聚合化合物；一种含有该化合物的液晶组合物；以及一种包括该组合物的液晶显示设备。 其手段包括由式（1）表示的化合物和含有该化合物的液晶组合物。 在式 (1) 中，R1、R2 和 R3 独立地为烷基或类似物；n 为 0 或类似物；环 A1 为苯基或类似物，环 A2 和环 A3 独立地为 1,4-亚苯基或类似物；Z1 和 Z2 独立地为单键或类似物；Sp1至Sp4为单键或类似物；a为1或类似物；c、d和e独立地为0或1，且c、d和e之和为1或类似物；以及P1至P4为可聚合基团，且P1至P4中至少有一个为式（P-1）所代表的可聚合基团。
• Cellulose acylate film, process for producing cellulose acylate film, polarizing plate and liquid crystal display device
  申请人：Fukagawa Nobutaka

  公开号：US20060093759A1

  公开（公告）日：2006-05-04

  A cellulose acylate film that has: an in-plane retardation Re and a retardation Rth in a thickness direction at a wavelength of 590 nm, which are satisfied with ranges of expressions (I) to (III); a coefficient of a thermal expansion of from 20 ppm/° C. to 100 ppm/° C.; and a haze of from 0.01 to 0.8, and a polarizing plate and a display device using the same. 20≦Re≦50  Expression (I) 70≦Rth≦200  Expression (II) 1.0≦Rth/Re≦3.0  Expression (III) In the foregoing expressions, each of Re and Rth is a value at 25° C. and 60% RH, and has a unit of nm.

  一种丙烯酸纤维素薄膜，其在波长为 590 纳米时的面内阻滞率 Re 和厚度方向上的阻滞率 Rth 符合表达式 (I) 至 (III) 的范围；热膨胀系数为 20 ppm/°C 至 100 ppm/°C；雾度为 0.01 至 0.8，以及使用该薄膜的偏光板和显示装置。 20≦Re≦50 Expression (I) 70≦Rth≦200 Expression (II) 1.0≦Rth/Re≦3.0 表达式 (III) 在上述表达式中，Re 和 Rth 均为 25° C 和 60% 相对湿度下的数值，单位为纳米。