(3R)-3-phenyl-3-phenylsulfanylpropanal | 1529806-42-5

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: (3R)-3-phenyl-3-phenylsulfanylpropanal
• CAS: 1529806-42-5
• 化学式: C₁₅H₁₄OS
• 分子量: 242.342
• InChiKey: OBOPLZQQDLJNFG-OAHLLOKOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  42.4
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (3R)-3-phenyl-3-phenylsulfanylpropanal 在 sodium tetrahydroborate 作用下， 以 乙醇 为溶剂， 反应 1.0h， 生成 (R)-3-phenyl-3-(phenylsulfanyl)propan-1-ol
  参考文献：
  名称：

  The study of biocatalyzed thio-Michael reaction: a greener and multi-gram protocol

  摘要：

  This Letter introduces a new, cheap and green protocol for the thio-Michael reaction. Here we applied three free enzymes such as lipase from pancreas porcine, chymosin and papain and an immobilized one: the Liposyme (R). The reactions were executed at room temperature and resulted in the thio-Michael adduct in good or excellent yields. The protocol describes the use of EtOH as solvent and a less percentage of enzymes, which is in concordance with the green chemistry topics, so we can mention that chymosin and papain were used as biocatalyst in an organic reaction for the first time in this Letter. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.11.047
• 作为产物：
  描述：

  苯硫酚 、 肉桂醛 在 lipase from pancreas porcine type II 作用下， 以 乙醇 为溶剂， 反应 2.0h， 以97%的产率得到
  参考文献：
  名称：

  The study of biocatalyzed thio-Michael reaction: a greener and multi-gram protocol

  摘要：

  This Letter introduces a new, cheap and green protocol for the thio-Michael reaction. Here we applied three free enzymes such as lipase from pancreas porcine, chymosin and papain and an immobilized one: the Liposyme (R). The reactions were executed at room temperature and resulted in the thio-Michael adduct in good or excellent yields. The protocol describes the use of EtOH as solvent and a less percentage of enzymes, which is in concordance with the green chemistry topics, so we can mention that chymosin and papain were used as biocatalyst in an organic reaction for the first time in this Letter. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.11.047

文献信息

• The study of biocatalyzed thio-Michael reaction: a greener and multi-gram protocol
  作者：Paula V.S. Rizzo、Ligia A. Boarin、Ingridhy O.M. Freitas、Roberto S. Gomes、Adilson Beatriz、Andrelson W. Rinaldi、Nelson Luís C. Domingues

  DOI：10.1016/j.tetlet.2013.11.047

  日期：2014.1

  This Letter introduces a new, cheap and green protocol for the thio-Michael reaction. Here we applied three free enzymes such as lipase from pancreas porcine, chymosin and papain and an immobilized one: the Liposyme (R). The reactions were executed at room temperature and resulted in the thio-Michael adduct in good or excellent yields. The protocol describes the use of EtOH as solvent and a less percentage of enzymes, which is in concordance with the green chemistry topics, so we can mention that chymosin and papain were used as biocatalyst in an organic reaction for the first time in this Letter. (C) 2013 Elsevier Ltd. All rights reserved.