Mechanistic Investigation on the Formation of Indolizines from 2-Enynylpyridines
作者:Inma R. Lahoz、Cristina Sicre、Armando Navarro-Vázquez、Carlos Silva López、María-Magdalena Cid
DOI:10.1021/ol901760a
日期:2009.11.5
2,3,7-Trisubstituted indolizines were obtained from E- or Z-2-enynyl-4-substituted pyridines. The mechanistic pathway involves a base-catalyzed double-bond isomerization, if the E-isomer is the starting material, followed by a concerted pseudocoarctate cyclization.