7-hydroxy-8-methyl-5-thioxo-3-(p-tolyl)-1-(p-tolylazo)-5,6-dihydro-3H-pyrido[3,4-d]pyridazin-4-one | 1034774-36-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 7-hydroxy-8-methyl-5-thioxo-3-(p-tolyl)-1-(p-tolylazo)-5,6-dihydro-3H-pyrido[3,4-d]pyridazin-4-one
• 英文别名: 8-methyl-3-(4-methylphenyl)-1-[(4-methylphenyl)diazenyl]-5-sulfanyl-6H-pyrido[3,4-d]pyridazine-4,7-dione
• CAS: 1034774-36-1
• 化学式: C₂₂H₁₉N₅O₂S
• 分子量: 417.491
• InChiKey: AHTTYSDNTZYYOA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  30
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  87.5
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  N,N-dimethyl-N'-(7-methyl-4-oxo-3-(p-tolyl)-1-(p-tolylazo)-3,4-dihydrothieno[3,4-d]pyridazin-5-yl)formamidine 在 乙酸铵 、 溶剂黄146 作用下， 反应 0.42h， 以64%的产率得到7-hydroxy-8-methyl-5-thioxo-3-(p-tolyl)-1-(p-tolylazo)-5,6-dihydro-3H-pyrido[3,4-d]pyridazin-4-one
  参考文献：
  名称：

  Studies with Condensed Aminothiophenes: Microwave Assisted Cycloaddition Reactions of Thieno[3,4-d]pyridazinone and Thieno[3,4-c]quinolinone

  摘要：

  DOI：

  10.3987/com-07-11301

文献信息

• Disperse Dyes Based on Aminothiophenes: Their Dyeing Applications on Polyester Fabrics and Their Antimicrobial Activity
  作者：Saleh Al-Mousawi、Morsy El-Apasery、Huda Mahmoud

  DOI：10.3390/molecules18067081

  日期：——

  A series of monoazo disperse dyes derived from arylazothienopyridazines were synthesized. Fastness properties of dyed polyester samples were measured. Most of the dyed fabrics tested displayed excellent washing and perspiration fastness and moderate light fastness. Finally, the biological activity of the synthesized dyes against Gram positive bacteria, Gram negative bacteria and yeast were evaluated

  合成了一系列衍生自芳基偶氮噻吩并哒嗪的单偶氮分散染料。测定染色聚酯样品的牢度性能。大多数测试的染色织物显示出优异的耐洗和汗渍牢度以及中等的耐光牢度。最后，评价了合成染料对革兰氏阳性菌、革兰氏阴性菌和酵母菌的生物活性。
• Studies with Condensed Aminothiophenes: Microwave Assisted Cycloaddition Reactions of Thieno[3,4-d]pyridazinone and Thieno[3,4-c]quinolinone
  作者：Saleh Mohammed Al-Mousawi、Morsy Ahmed EL-Apasery、Mohamed Hilmy Elnagdi

  DOI：10.3987/com-07-11301

  日期：——