6-fluoro-5-(4-methoxyphenyl)-8,9-dihydro-7H-benzo[7]annulene | 1269617-56-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 6-fluoro-5-(4-methoxyphenyl)-8,9-dihydro-7H-benzo[7]annulene
• CAS: 1269617-56-2
• 化学式: C₁₈H₁₇FO
• 分子量: 268.331
• InChiKey: GVCBTJKNNCQABX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2--benzo<3,4>cyclohepten-(1) 在 Selectfluor 作用下， 以 乙腈 为溶剂， 以81%的产率得到6-fluoro-5-(4-methoxyphenyl)-8,9-dihydro-7H-benzo[7]annulene
  参考文献：
  名称：

  Halogenation of 1,1-diaryl alkenes

  摘要：

  A variety of vinyl halides were prepared from reaction of 1,1-diarylalkenes with different halogenating agents (e.g., Selectfluor and N-halosuccinimide) with good yields under mild and base-free conditions. Synthesis of these molecules has been reported in the literature for being not easy to conduct. Among all the existing preparations of vinyl halide procedures, this protocol has the most facile and practical process. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.12.041

文献信息

• Halogenation of 1,1-diaryl alkenes
  作者：Meng-Yang Chang、Ming-Fang Lee、Chung-Han Lin、Nein-Chia Lee

  DOI：10.1016/j.tetlet.2010.12.041

  日期：2011.2

  A variety of vinyl halides were prepared from reaction of 1,1-diarylalkenes with different halogenating agents (e.g., Selectfluor and N-halosuccinimide) with good yields under mild and base-free conditions. Synthesis of these molecules has been reported in the literature for being not easy to conduct. Among all the existing preparations of vinyl halide procedures, this protocol has the most facile and practical process. (C) 2010 Elsevier Ltd. All rights reserved.