(2R,6S)-2,6-Diallyl-piperidine-1-carboxylic acid benzyl ester | 446873-77-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2R,6S)-2,6-Diallyl-piperidine-1-carboxylic acid benzyl ester
• 英文别名: benzyl (2R,6S)-2,6-bis(prop-2-enyl)piperidine-1-carboxylate
• CAS: 446873-77-4
• 化学式: C₁₉H₂₅NO₂
• 分子量: 299.413
• InChiKey: HDQWMVWZEQCRRA-HDICACEKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  22
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (2R,6S)-2,6-Diallyl-piperidine-1-carboxylic acid benzyl ester 在 Grubbs catalyst first generation 作用下， 以 二氯甲烷 为溶剂， 反应 15.0h， 生成 11-azabicyclo[5.3.1]dec-3-ene-11-carboxylic acid phenylmethyl ester
  参考文献：
  名称：

  A ring-closing olefin metathesis approach to bridged azabicyclic structures

  摘要：

  A facile and general entry to functionalized bridged bicyclic nitrogen heterocycles has been developed that involves the ring-closing metathesis (RCM) of cis-2,6-dialkenyl-N-acyl piperidines that were readily prepared from glutarimide or 4-methoxypyridine. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(02)00100-4
• 作为产物：
  描述：

  6-(2-propenyl)piperidin-2-one 在 正丁基锂 、 二异丁基氢化铝 作用下， 以 四氢呋喃 、 甲苯 为溶剂， 生成 (2R,6S)-2,6-Diallyl-piperidine-1-carboxylic acid benzyl ester
  参考文献：
  名称：

  A ring-closing olefin metathesis approach to bridged azabicyclic structures

  摘要：

  A facile and general entry to functionalized bridged bicyclic nitrogen heterocycles has been developed that involves the ring-closing metathesis (RCM) of cis-2,6-dialkenyl-N-acyl piperidines that were readily prepared from glutarimide or 4-methoxypyridine. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(02)00100-4

文献信息

• A ring-closing olefin metathesis approach to bridged azabicyclic structures
  作者：Christopher E Neipp、Stephen F Martin

  DOI：10.1016/s0040-4039(02)00100-4

  日期：2002.3

  A facile and general entry to functionalized bridged bicyclic nitrogen heterocycles has been developed that involves the ring-closing metathesis (RCM) of cis-2,6-dialkenyl-N-acyl piperidines that were readily prepared from glutarimide or 4-methoxypyridine. (C) 2002 Elsevier Science Ltd. All rights reserved.