Gly-Arg-Gly-Asp-Tyr-OH

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Gly-Arg-Gly-Asp-Tyr-OH
• 英文别名: GRGDY；Gly-Arg-Gly-Asp-Tyr；(3S)-3-[[2-[[(2S)-2-[(2-aminoacetyl)amino]-5-(diaminomethylideneamino)pentanoyl]amino]acetyl]amino]-4-[[(1S)-1-carboxy-2-(4-hydroxyphenyl)ethyl]amino]-4-oxobutanoic acid
• 化学式: C₂₃H₃₄N₈O₉
• 分子量: 566.571
• InChiKey: OBLNMUKJWUIHTD-JYJNAYRXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -5.6
• 重原子数：
  40
• 可旋转键数：
  17
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  302
• 氢给体数：
  10
• 氢受体数：
  11

反应信息

• 作为反应物：
  描述：

  sulfo-SANPAH 、 Gly-Arg-Gly-Asp-Tyr-OH 以 乙醇 、 水 为溶剂， 反应 2.0h， 生成
  参考文献：
  名称：

  Homogeneous synthesis of GRGDY grafted chitosan on hydroxyl groups by photochemical reaction for improved cell adhesion

  摘要：

  A novel homogeneous synthesis route was presented to produce RGD-containing peptide modified chitosan (CTS) with purpose of improving cell adhesion and growth. Bifunctional photosensitive crosslinker, Sulfo-SANPAH, was used to link cell adhesive peptide GRGDY and CTS under controlled condition. The synthesis process was proved by FTIR, MALDI-TOF MS and H-1 NMR analyses, and the mechanism was demonstrated clearly and completely that hydroxyl groups of CTS were prior: to amino groups for nucleophilic reaction with Sulfo-SANPAH. Moreover, cell adhesion and proliferation were evaluated for GRGDY grafted CTS. The results showed that GRGDY grafted CTS formed by the novel strategy had potential application not only as drug or gene carriers but also as tissue engineered scaffolds. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.carbpol.2009.12.019

文献信息

• IMPLANTABLE MATERIALS HAVING ENGINEERED SURFACES AND METHOD OF MAKING SAME
  申请人：CHOUBEY Animesh

  公开号：US20090304772A1

  公开（公告）日：2009-12-10

  Implantable materials having engineered surfaces and method of making same comprising geometric features on at least one surface of the material having at least one of chemical, physiochemical and electrochemical activity different than regions of the at least one surface without the features.
• US8268340B2
  申请人：——

  公开号：US8268340B2

  公开（公告）日：2012-09-18
• US8932347B2
  申请人：——

  公开号：US8932347B2

  公开（公告）日：2015-01-13
• [EN] IMPLANTABLE MATERIALS HAVING ENGINEERED SURFACES AND METHOD OF MAKING SAME<br/>[FR] MATÉRIAUX IMPLANTABLES À SURFACES MODIFIÉES ET PROCÉDÉ DE FABRICATION ASSOCIÉ
  申请人：ADVANCED BIO PROSTHETIC SURFAC

  公开号：WO2010124072A2

  公开（公告）日：2010-10-28

  Implantable materials having engineered surfaces and method of making same comprising geometric features on at least one surface of the material having at least one of chemical, physiochemical and electrochemical activity different than regions of the at least one surface without the features.
• Homogeneous synthesis of GRGDY grafted chitosan on hydroxyl groups by photochemical reaction for improved cell adhesion
  作者：Yan Yang、Xiudong Liu、Weiting Yu、Houjiang Zhou、Xiaoxia Li、Xiaojun Ma

  DOI：10.1016/j.carbpol.2009.12.019

  日期：2010.5

  A novel homogeneous synthesis route was presented to produce RGD-containing peptide modified chitosan (CTS) with purpose of improving cell adhesion and growth. Bifunctional photosensitive crosslinker, Sulfo-SANPAH, was used to link cell adhesive peptide GRGDY and CTS under controlled condition. The synthesis process was proved by FTIR, MALDI-TOF MS and H-1 NMR analyses, and the mechanism was demonstrated clearly and completely that hydroxyl groups of CTS were prior: to amino groups for nucleophilic reaction with Sulfo-SANPAH. Moreover, cell adhesion and proliferation were evaluated for GRGDY grafted CTS. The results showed that GRGDY grafted CTS formed by the novel strategy had potential application not only as drug or gene carriers but also as tissue engineered scaffolds. (C) 2009 Elsevier Ltd. All rights reserved.