(R)-2-Amino-3-mercapto-propionic acid butyl ester

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (R)-2-Amino-3-mercapto-propionic acid butyl ester
• 英文别名: Cysteine, butyl ester；butyl (2R)-2-amino-3-sulfanylpropanoate
• 化学式: C₇H₁₅NO₂S
• 分子量: 177.268
• InChiKey: CYJYHSYAYORDLU-LURJTMIESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  11
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  53.3
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  光气 、 (R)-2-Amino-3-mercapto-propionic acid butyl ester 以 甲苯 、 苯 为溶剂， 以94%的产率得到butyl L-2-oxothiazolidine-4-carboxylate
  参考文献：
  名称：

  Arapov, O. V.; Borisova, M. A.; Krasil'nikov, I. I., Russian Journal of Applied Chemistry, 1995, vol. 68, # 2.2, p. 294 - 296

  摘要：

  DOI：

文献信息

• Integrin interaction inhibitors for the treatment of cancer
  申请人：H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

  公开号：US10059740B2

  公开（公告）日：2018-08-28

  Integrin interaction inhibitors using a beta-turn promoter are described herein. These peptides are useful in treating cancer, such as multiple myeloma, by administering a therapeutically effective amount of the integrin interaction inhibitor. Data show that integrin interaction inhibitors act synergistically or additively interact with anti-proliferative agents such as doxorubicin, SAHA, arsenic trioxide, and etoposide.

  本文描述了使用β-转角促进剂的整合素相互作用抑制剂。这些肽对治疗癌症，如多发性骨髓瘤，是有用的，通过给予整合素相互作用抑制剂的治疗有效量。数据显示整合素相互作用抑制剂与抗增殖剂（如阿霉素、SAHA、三氧化二砷和依托泊苷）具有协同作用或加成作用。
• INTEGRIN INTERACTION INHIBITORS FOR THE TREATMENT OF CANCER
  申请人：Hazlehurst Lori

  公开号：US20130065837A1

  公开（公告）日：2013-03-14

  Integrin interaction inhibitors using a beta-turn promoter are described herein. These peptides are useful in treating cancer, such as multiple myeloma, by administering a therapeutically effective amount of the integrin interaction inhibitor. Data show that integrin interaction inhibitors act synergistically or additively interact with anti-proliferative agents such as doxorubicin, SAHA, arsenic trioxide, and etoposide.

  本文描述了使用β-转角促进剂的整合素相互作用抑制剂。通过给予治疗有效量的整合素相互作用抑制剂，这些肽对于治疗癌症，如多发性骨髓瘤，是有用的。数据表明，整合素相互作用抑制剂与抗增殖剂（如多柔比星，SAHA，三氧化二砷和依托泊苷）呈协同或加成作用。
• [EN] SALT OF ABT-263 AND SOLID-STATE FORMS THEREOF<br/>[FR] SEL DE ABT-263 ET FORMES SOLIDES DE CELUI-CI
  申请人：ABBOTT LAB

  公开号：WO2010127190A1

  公开（公告）日：2010-11-04

  ABT-263 bis-HCl and crystalline polymorphs thereof are suitable active pharmaceutical ingredients for pharmaceutical compositions useful in treatment of a disease characterized by overexpression of one or more anti-apoptotic Bcl-2 family proteins, for example cancer.

  ABT-263 bis-HCl及其结晶多形体是适用于制备药物组合物的有效药物成分，用于治疗一种疾病，该疾病以一个或多个抗凋亡Bcl-2家族蛋白质的过度表达为特征，例如癌症。
• PEPTIDES FOR THE TREATMENT OF CANCER
  申请人：H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

  公开号：US20150071918A1

  公开（公告）日：2015-03-12

  The invention relates to novel cyclic compounds (cyclic peptides), linkers useful as beta-turn promoters in cyclic peptides, and methods for treatment of malignant cells in vitro or in vivo using one or more linear and cyclic peptides. The peptides can act as integrin interaction inhibitors and may be used in the treatment of cancers as monotherapies or in combination with other anti-cancer agents, such as proteasome inhibitors, inhibitors of autophagy, alkylating agents, MEK inhibitors, FAK/PYK2 inhibitors, and EGFR inhibitors. The invention further concerns a method of predicting the binding of a cyclic or linear HYD1 peptide to a cancer cell by assessing overexpression of biomarkers such as CD44, VLA-4 integrin, basigin, CD138 (syndecan 1), NCAM, ICAM1, ICAM3, and CD59. The invention further concerns a method of detecting one or more members of a complex comprising CD44, VLA-4 integrin, basigin, CD138 (syndecan 1), NCAM, ICAM1, ICAM3, and CD59, using a linear or cyclic HYD1 peptide bearing a detectable moiety.

  本发明涉及新型环状化合物（环状肽）、在环状肽中作为β-转角促进剂有用的连接剂，以及使用一种或多种线性和环状肽治疗体外或体内恶性细胞的方法。这些肽可以作为整合素相互作用抑制剂，并可用于单独治疗或与其他抗癌药物（如蛋白酶体抑制剂、自噬抑制剂、烷化剂、MEK抑制剂、FAK/PYK2抑制剂和EGFR抑制剂）联合治疗癌症。本发明进一步涉及通过评估过表达的生物标志物（如CD44、VLA-4整合素、basigin、CD138（syndecan 1）、NCAM、ICAM1、ICAM3和CD59）来预测环状或线性HYD1肽与癌细胞结合的方法。本发明还涉及一种使用带有可检测基团的线性或环状HYD1肽检测CD44、VLA-4整合素、basigin、CD138（syndecan 1）、NCAM、ICAM1、ICAM3和CD59复合物中一种或多种成员的方法。
• APPARATUS AND METHOD FOR PRODUCING RESIN
  申请人：TEIJIN LIMITED

  公开号：EP1120435A1

  公开（公告）日：2001-08-01

  A method of producing a polycarbonate or the like which is excellent in hydrolysis and heat stability such as a reduction in molecular weight at the time of molding and color retention and moldability such as releasability and transferability, rarely experiences residence deterioration such as coloring, crosslinking and gel formation and has an extremely small content of foreign matter by employing a special structure for an opening in the side surface of a horizontal cylindrical vacuum resin treating apparatus, supplying a molten polycarbonate into a unidirectional rotary intermeshing double-screw extruder under specific conditions, adding a specific agent under specific conditions and cleaning the inner surface of a production apparatus by a specific method.

  一种聚碳酸酯或类似物的生产方法，该聚碳酸酯或类似物具有优异的水解稳定性和热稳定性（如成型时分子量降低）以及保色性和成型性（如脱模性和转移性），很少发生着色等居住劣化、通过在卧式圆柱形真空树脂处理装置的侧表面开口处采用特殊结构，在特定条件下将熔融聚碳酸酯送入单向旋转啮合双螺杆挤出机，在特定条件下添加特定药剂，并通过特定方法清洁生产装置的内表面，可生产出异物含量极低的聚碳酸酯。