Asn-Pro | 78346-95-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Asn-Pro
• 英文别名: (2S)-1-[(2S)-2,4-diamino-4-oxobutanoyl]pyrrolidine-2-carboxylic acid
• CAS: 78346-95-9
• 化学式: C₉H₁₅N₃O₄
• 分子量: 229.236
• InChiKey: GADKFYNESXNRLC-WDSKDSINSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.2
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  127
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  Nε-Z-NAlpha-叔丁氧羰基-L-赖氨酸羟基琥珀酰亚胺酯 、 Asn-Pro 生成 (2S)-1-[(2S)-4-amino-2-[[(2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-6-(phenylmethoxycarbonylamino)hexanoyl]amino]-4-oxobutanoyl]pyrrolidine-2-carboxylic acid
  参考文献：
  名称：

  ONOPRIENKO, L. V.;MIXALEVA, I. I.;LUNEV, V. E.;NESMEYANOV, V. A.;IVANOV, +, BIOORGAN. XIMIYA, 15,(1989) N, S. 908-921

  摘要：

  DOI：
• 作为产物：
  描述：

  N²-(tert-butoxycarbonyl)-L-asparaginyl-L-proline 以99%的产率得到
  参考文献：
  名称：

  ONOPRIENKO, L. V.;MIXALEVA, I. I.;LUNEV, V. E.;NESMEYANOV, V. A.;IVANOV, +, BIOORGAN. XIMIYA, 15,(1989) N, S. 908-921

  摘要：

  DOI：

文献信息

• N-carboxyalkyl dipeptides, a process for preparing and a pharmaceutical composition comprising the same
  申请人：Merck & Co., Inc.

  公开号：EP0049506A1

  公开（公告）日：1982-04-14

  N-Carboxyalkyl dipeptides and derivatives thereof are disclosed which are useful as angiotensin converting enzyme inhibitors and as antihypertensives, and a process for preparing them. Those compounds are represented by the formula wherein R and R5 are individually hydroxy, lower alkoxy, aralkoxy; R1 is C1-8 alkyl; substituted C1-5 alkyl, substituted aralkyl or substituted heteroaralkyl; R2 is hydroxy, amino, alkoxy, aralkyloxy; n is one, two or three; R3 is aryl, heteroaryl, cycloalkyl, aminoloweralkyl, aralkyl; R4 is hydrogen or loweralkyl; or R3 and R4 are joined to form a ring having the following formulae: R6 is hydrogen or loweralkyl; p is 1, 2, or 3; W is a bond, -CH2-, or C=O; and, Z is a bond, -CH2-, or -CH2CH2-; and, the pharmaceutically acceptable salts thereof.

  本发明公开了可用作血管紧张素转换酶抑制剂和抗高血压药的 N-羧烷基二肽及其衍生物，以及制备它们的工艺。 这些化合物用式表示 式中 R 和 R5 分别为羟基、低级烷氧基、烷氧基； R1 是 C1-8 烷基、取代的 C1-5 烷基、取代的芳基或取代的杂烷基； R2 是羟基、氨基、烷氧基、烷氧基； n 是 1、2 或 3； R3 是芳基、杂芳基、环烷基、氨基低级烷基、芳基； R4 是氢或低级烷基；或 R3 和 R4 连接形成具有下式的环： R6是氢或低级烷基；p是1、2或3；W是键、-CH2-或C=O；Z是键、- -或- -；及其药学上可接受的盐。
• Novel synthetic, immunologically active peptides useful for the preparation of antimalarial vaccines
  申请人：ENIRICERCHE S.p.A.

  公开号：EP0345867A1

  公开（公告）日：1989-12-13

  Synthetic peptides constituted by at least two repeating, consecutive units of asparaginyl-proline (Asn-­Pro)n sequence, are novel. Said peptides are power ful immunogens, capable of inducing in laboratory animals the formation of a high concentration of antibodies capable of reacting both with the (Asn-Pro)n peptides, and with the immunodominant epitope of the circumsporozoite protein of Plasmodium falciparum. Said peptides, which can be obtained in a pure form by chemical synthesis are particularly useful for preparing antimalarial vaccines, and diagnostic kits for the determination of malaria on man.

  由至少两个天冬酰胺基-脯氨酸（Asn-Pro）n 序列的连续重复单元构成的合成肽是一种新型肽。 这些肽是强效免疫原，能够在实验动物体内诱导形成高浓度的抗体，这些抗体既能与（Asn-Pro）n 肽反应，也能与恶性疟原虫周孢子虫蛋白的免疫优势表位反应。 这些肽可以通过化学合成获得纯品，特别适用于制备抗疟疫苗和用于确定人类疟疾的诊断试剂盒。
• Nutrient compositions containing peptides
  申请人：CLINTEC NUTRITION COMPANY

  公开号：EP0457314A1

  公开（公告）日：1991-11-21

  Nutrient compositions comprise an aqueous solution of at least one dipeptide with an N-terminal amino acid selected from glutamine, aspargine, tyrosine, tryptophan, and aspargine. The C-terminal amino acid is alanine, glycine, tryptophan, arginine, proline or serine. The nutritional compositions contain from about 0.1 to 25.0 percent by weight of oligopeptides, preferably about 0.5 to 5.0 percent by weight.

  营养组合物包含至少一种二肽的水溶液，其 N 端氨基酸选自谷氨酰胺、天门冬氨酸、酪氨酸、色氨酸和天门冬氨酸。 C 端氨基酸为丙氨酸、甘氨酸、色氨酸、精氨酸、脯氨酸或丝氨酸。营养组合物含有约 0.1%至 25.0%（按重量计）的低聚肽，最好是约 0.5%至 5.0%（按重量计）。
• Functional Identification and Structure Determination of Two Novel Prolidases from cog1228 in the Amidohydrolase Superfamily,
  作者：Dao Feng Xiang、Yury Patskovsky、Chengfu Xu、Alexander A. Fedorov、Elena V. Fedorov、Abby A. Sisco、J. Michael Sauder、Stephen K. Burley、Steven C. Almo、Frank M. Raushel

  DOI：10.1021/bi100897u

  日期：2010.8.10

  Two uncharacterized enzymes from the amidohydrolase superfamily belonging to cog1228 were cloned, expressed, and purified to homogeneity. The two proteins, Sgx9260c (gi|44242006) and Sgx9260b (gi|44479596), were derived from environmental DNA samples originating from the Sargasso Sea. The catalytic function and substrate profiles for Sgx9260c and Sgx9260b were determined using a comprehensive library of dipeptides and N-acyl derivative of L-amino acids. Sgx9260c catalyzes the hydrolysis of Gly-L-Pro, L-Ala-L-Pro, and N-acyl derivatives of L-Pro. The best substrate identified to date is N-acetyl-L-Pro with a value of k(cat)/K-m of 3 x 10(5) M-1 s(-1). Sgx9260b catalyzes the hydrolysis of L-hydrophobic L-Pro dipeptides and N-acyl derivatives of L-Pro. The best substrate identified to date is N-propionyl-L-Pro with a value of k(cat)/K-m of 1 x 10(5) M-1 s(-1). Three-dimensional structures of both proteins were determined by X-ray diffraction methods (PDB codes 3MKV and 3FEQ). These proteins fold as distorted (beta/alpha)(8)-barrels with two divalent cations in the active site. The structure of Sgx9260c was also determined as a complex with the N-methylphosphonate derivative of L-Pro (PDB code 3N2C). In this structure the phosphonate moiety bridges the binuclear metal center, and one oxygen atom interacts with His-140. The a-carboxylate of the inhibitor interacts with Tyr-231. The proline side chain occupies a small substrate binding cavity formed by residues contributed from the loop that follows beta-strand 7 within the (beta/alpha)(8)-barrel. A total of 38 other proteins from cog1228 are predicted to have the same substrate profile based on conservation of the substrate binding residues. The structure of an evolutionarily related protein, Cc2672 from Caulobacter crecentus, was determined as a complex with the N-methylphosphonate derivative of L-arginine (PDB code 3MTW).
• US5116946A
  申请人：——

  公开号：US5116946A

  公开（公告）日：1992-05-26