Nicotinaldehyde 5H-(1,2,4)triazino(5,6-b)indol-3-ylhydrazone | 73718-28-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: Nicotinaldehyde 5H-(1,2,4)triazino(5,6-b)indol-3-ylhydrazone
• 英文别名: N-[(E)-pyridin-3-ylmethylideneamino]-5H-[1,2,4]triazino[5,6-b]indol-3-amine
• CAS: 73718-28-2
• 化学式: C₁₅H₁₁N₇
• 分子量: 289.29
• InChiKey: RSFGPHAYVGOZNX-RQZCQDPDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  91.7
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  3-hydrazino-5H-[1,2,4]triazino[5,6-b]indole 、 3-吡啶甲醛 以100%的产率得到
  参考文献：
  名称：

  RAM V. J., ARCH. PHARM., 1980, 313, NO 2, 108-113

  摘要：

  DOI：

文献信息

• TGF-BETA MODULATORS AND METHODS FOR USING THE SAME
  申请人：Burmester James K.

  公开号：US20090176870A1

  公开（公告）日：2009-07-09

  The present invention provides a method of modulating TGF-β activity in a subject. Methods of the present invention comprise administering to the subject an effective amount of a compound of the formula: or a salt, prodrug, tautomer, hydrate, solvate, or stereoisomer thereof, wherein a is an integer from 0 to 4; each R 1 is independently hydroxy, alkoxy, halide, alkyl, cyano, nitro, amino, monoalkylamino, dialkylamino, or carboxy; R 2 is aryl, cycloalkyl, alkenyl, or alkyl, each of which is optionally substituted; each of X 1 and X 2 is independently O, S or NR 3 , wherein R 3 is hydrogen or alkyl; X 3 is hydrogen, alkoxy, alkyl, hydroxy, halide, amino, monoalkylamino, or dialkylamino; and X 4 is alkoxy, hydroxy, halide, amino, monoalkylamino, or dialkylamino.
• RAM V. J., ARCH. PHARM., 1980, 313, NO 2, 108-113
  作者：RAM V. J.

  DOI：——

  日期：——