2,2'-Dihydroxy-4-tert.-butylbiphenyl | 30534-85-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,2'-Dihydroxy-4-tert.-butylbiphenyl
• 英文别名: 4-Tert-butyl-2-(2-hydroxyphenyl)phenol
• CAS: 30534-85-1
• 化学式: C₁₆H₁₈O₂
• 分子量: 242.318
• InChiKey: WJAIDEHMYYIOKS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2,2'-Dihydroxy-4-tert.-butylbiphenyl 、 乙酸酐 在 吡啶 作用下， 以 四氢呋喃 为溶剂， 生成 [2-(2-Acetyloxyphenyl)-4-tert-butylphenyl] acetate
  参考文献：
  名称：

  Synthesis of Unsymmetrical o-Biphenols and o-Binaphthols via Silicon-Tethered Pd-Catalyzed C−H Arylation

  摘要：

  A mild, practical, and efficient method for the synthesis of unsymmetrical o-biphenols (including o-phenol-naphthols and o-binaphthols) has been developed. Unsymmetrical bis-aryloxy silanes, which were readily prepared in a semi-one-pot fashion, underwent the Pd-catalyzed intramolecular arylation followed by a routine TBAF desilylation step to furnish valuable unsymmetrical biphenols without necessity of isolation of seven-membered intermediates. The excellent functional group tolerance allows for synthesis of a variety of functionalized o-biphenols and o-binaphthols from easily available staring materials.

  DOI：

  10.1021/ol100924n
• 作为产物：
  描述：

  在 四丁基氟化铵 作用下， 以 四氢呋喃 为溶剂， 反应 2.0h， 生成 2,2'-Dihydroxy-4-tert.-butylbiphenyl
  参考文献：
  名称：

  Synthesis of Unsymmetrical o-Biphenols and o-Binaphthols via Silicon-Tethered Pd-Catalyzed C−H Arylation

  摘要：

  A mild, practical, and efficient method for the synthesis of unsymmetrical o-biphenols (including o-phenol-naphthols and o-binaphthols) has been developed. Unsymmetrical bis-aryloxy silanes, which were readily prepared in a semi-one-pot fashion, underwent the Pd-catalyzed intramolecular arylation followed by a routine TBAF desilylation step to furnish valuable unsymmetrical biphenols without necessity of isolation of seven-membered intermediates. The excellent functional group tolerance allows for synthesis of a variety of functionalized o-biphenols and o-binaphthols from easily available staring materials.

  DOI：

  10.1021/ol100924n

文献信息

• [EN] GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES<br/>[FR] ANTAGONISTE DES RECEPTEURS DU GLUCAGON, PREPARATION ET UTILISATIONS THERAPEUTIQUES
  申请人：LILLY CO ELI

  公开号：WO2005123668A1

  公开（公告）日：2005-12-29

  The present invention discloses novel compounds of Formula I, or pharmaceutically acceptable salts thereof, which have glucagon receptor antagonist or inverse agonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I as well as methods of using them to treat diabetic and other glucagon related metabolic disorders, and the like.

  本发明公开了具有胰高血糖素受体拮抗剂或逆拮抗剂活性的化合物I的新化合物，或其药用可接受的盐，以及制备这些化合物的方法。在另一实施例中，本发明公开了包含化合物I的药物组合物，以及使用它们治疗糖尿病和其他与胰高血糖素相关的代谢性疾病等方法。
• Glucagon Receptor Antagonists, Preparation and Therapeutic Uses
  申请人：Conner Eugene Scott

  公开号：US20070249688A1

  公开（公告）日：2007-10-25

  The present invention discloses novel compounds of Formula I, or pharmaceutically acceptable salts thereof, which have glucagon receptor antagonist or inverse agonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I as well as methods of using them to treat diabetic and other glucagon related metabolic disorders, and the like.

  本发明公开了化合物I式的新型化合物，或其药学上可接受的盐，其具有葡萄糖高素受体拮抗剂或反向激动剂活性，以及制备这些化合物的方法。在另一种实施方式中，本发明还公开了包括I式化合物的药物组合物，以及使用它们治疗糖尿病和其他与葡萄糖高素相关的代谢性疾病的方法等。
• GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES
  申请人：CONNER Scott Eugene

  公开号：US20110124648A1

  公开（公告）日：2011-05-26

  The present invention discloses novel compounds of Formula I, or pharmaceutically acceptable salts thereof, which have glucagon receptor antagonist or inverse agonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I as well as methods of using them to treat diabetic and other glucagon related metabolic disorders, and the like.

  本发明披露了式I的新型化合物或其药学上可接受的盐，其具有胰高血糖素受体拮抗剂或反向激动剂活性，以及制备这种化合物的方法。在另一种实施方式中，本发明还披露了包含式I化合物的药物组合物，以及使用它们治疗糖尿病和其他胰高血糖素相关代谢紊乱等疾病的方法。
• Glucagon receptor antagonists, preparation and therapeutic uses
  申请人：Eli Lilly & Company

  公开号：EP2159221A1

  公开（公告）日：2010-03-03

  The present invention discloses novel compounds of Formula I, or pharmaceutically acceptable salts thereof, which have glucagon receptor antagonist or inverse agonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I as well as methods of using these compounds and compositions to treat diabetic and other glucagon related metabolic disorders, and the like.

  本发明公开了具有胰高血糖素受体拮抗剂或反向激动剂活性的新型式 I 化合物或其药学上可接受的盐，以及制备此类化合物的方法。在另一个实施方案中，本发明公开了包含式 I 化合物的药物组合物，以及使用这些化合物和组合物治疗糖尿病和其他胰高血糖素相关代谢紊乱等疾病的方法。
• Methods and apparatus for stabilization of surfaces
  申请人：Polylast Systems, LLC

  公开号：US10309070B2

  公开（公告）日：2019-06-04

  Various embodiments provide surface compositions and methods for porous, flexible, and durable surfaces that may stabilize native soil, provide substantially uniform drainage of moisture, and provide a barrier between the native soil, vegetation, and other compositions disposed over the surface composition, such as sand and/or soil. The compositions and methods may comprise utilizing a liquid coating composition, liquid binder, and/or antimicrobial composition in combination with a particulate material configured to provide a desired pore size, elasticity, compression, and/or stability to the surface composition. Various embodiments of the surface composition may form a prefabricated flexible bunker liner for application to the native soil in a golf course bunker beneath sand.

  各种实施方案提供了用于多孔、柔韧和耐用表面的表面组合物和方法，这些表面组合物和方法可以稳定原生土壤，提供基本均匀的水分排放，并在原生土壤、植被和放置在表面组合物上的其他组合物（如沙子和/或土壤）之间提供屏障。这些组合物和方法可包括利用液体涂层组合物、液体粘结剂和/或抗菌组合物与颗粒材料相结合，使表面组合物具有所需的孔径、弹性、压缩性和/或稳定性。表面组合物的各种实施方案可形成预制的柔性沙坑衬垫，用于高尔夫球场沙坑中沙下的原生土壤。