2-[(1H-benzimidazol-2-yl)sulfanyl]-N'-[(pyridin-3-yl)methylidene]acetohydrazide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 2-[(1H-benzimidazol-2-yl)sulfanyl]-N'-[(pyridin-3-yl)methylidene]acetohydrazide
• 英文别名: 2-(1H-Benzoimidazol-2-ylsulfanyl)-acetic acid pyridin-3-ylmethylene-hydrazide；2-(1H-benzimidazol-2-ylsulfanyl)-N-[(E)-pyridin-3-ylmethylideneamino]acetamide
• 化学式: C₁₅H₁₃N₅OS
• 分子量: 311.367
• InChiKey: VNXMFSBKKTXLQU-RQZCQDPDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  108
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-(苯并咪唑基硫代)乙酸 肼 、 3-吡啶甲醛 生成 2-[(1H-benzimidazol-2-yl)sulfanyl]-N'-[(pyridin-3-yl)methylidene]acetohydrazide
  参考文献：
  名称：

  Imtiaz Husain M., Kumar Vinay, Indian J. Chem. B, 32 (1993) N 8, S 905-907

  摘要：

  DOI：

文献信息

• Replacement of an Indole Scaffold Targeting Human 15‐Lipoxygenase‐1 Using Combinatorial Chemistry
  作者：Deka Prismawan、Ramon van der Vlag、Hao Guo、Frank J. Dekker、Anna K. H. Hirsch

  DOI：10.1002/hlca.201900040

  日期：2019.5

  Human 15‐lipoxygenase‐1 (15‐LOX‐1) belongs to the class of lipoxygenases, which catalyze oxygenation of polyunsaturated fatty acids, such as arachidonic and linoleic acid. Recent studies have shown that 15‐LOX‐1 plays an important role in physiological processes linked to several diseases such as airway inflammation disease, coronary artery disease, and several types of cancer such as rectal, colon

  人15-脂氧合酶-1（15-LOX-1）属于脂氧合酶，可催化多不饱和脂肪酸（如花生四烯酸和亚油酸）的氧化。最近的研究表明，15‐LOX-1在与多种疾病（如气道炎症，冠状动脉疾病）和多种癌症（如直肠癌，结肠癌，乳腺癌和前列腺癌）有关的生理过程中起着重要作用。在这项研究中，我们旨在从最近确定的吲哚基核心开始，扩展15-LOX-1抑制剂的结构多样性。为了找到新的脚手架，我们采用了组合方法，使用了各种芳族​​醛和脂肪族酰肼尾基。IC 50 = 16± 6μm）和快速有效的结构-活性关系研究。
• ADENYLYL CYCLASES AS NOVEL TARGETS FOR THE TREATMENT OF INFECTION BY EUKARYOTIC PATHOGENS
  申请人：Levin Lonny

  公开号：US20100063099A1

  公开（公告）日：2010-03-11

  The present invention relates to a method of preventing or treating a disease caused by infection by a eukaryotic pathogen, wherein the method comprises administering an effective amount of a modulator of a eukaryotic pathogen's adenylyl cyclase. The invention also provides pharmaceutical compositions useful for preventing or treating a disease, with the compositions containing a therapeutically effective amount of a modulator of a eukaryotic pathogen's adenylyl cyclase. The invention also provides screening methods for identifying selective modulators of a eukaryotic pathogen's adenylyl cyclase that do not substantially modulate an adenylyl cyclase of the subject. The invention also provides methods for culturing eukaryotic pathogens and methods for inducing the pathogenic state in vitro.
• ADENYLYL CYCLASES AS NOVEL TARGETS FOR ANTIBACTRIAL INTERVENTIONS
  申请人：Levin Lonny

  公开号：US20100168203A1

  公开（公告）日：2010-07-01

  The present invention relates to a method of preventing or treating a disease caused by bacterial infection by administering an effective amount of a modulator of bacterial adenylyl cyclase. The invention also provides pharmaceutical compositions useful for preventing or treating a disease, with the compositions containing a therapeutically effective amount of a modulator of bacterial adenylyl cyclase. The invention also provides screening methods for identifying selective modulators of bacterial adenylyl cyclase that do not substantially modulate adenylyl cyclase of the subject. The invention also provides methods for culturing bacterial pathogens and methods for inducing the pathogenic state in vitro.
• METHOD TO TREAT PSORIASIS AND OTHER HYPERPROLIFERATIVE SKIN DISORDERS
  申请人：Buck Jochen

  公开号：US20110305640A1

  公开（公告）日：2011-12-15

  Soluble adenylyl cyclase (sAC) is implicated in proliferation of keratinocytes. Inhibitors of sAC are useful for the treatment and/or prevention of psoriasis and other hyperproliferative skin disorders. Assays to identify such compounds are also described.
• US9017681B2
  申请人：——

  公开号：US9017681B2

  公开（公告）日：2015-04-28