(S)-2-(((benzyloxy)carbonyl)amino)-8-(tert-butoxy)-8-oxooctanoic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (S)-2-(((benzyloxy)carbonyl)amino)-8-(tert-butoxy)-8-oxooctanoic acid
• 英文别名: (2S)-8-[(2-methylpropan-2-yl)oxy]-8-oxo-2-(phenylmethoxycarbonylamino)octanoic acid
• 化学式: C₂₀H₂₉NO₆
• 分子量: 379.4
• InChiKey: WDWRIXWNPLSKDD-INIZCTEOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  27
• 可旋转键数：
  13
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  102
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  (S)-2-(((benzyloxy)carbonyl)amino)-8-(tert-butoxy)-8-oxooctanoic acid 、 2-(1h-Benzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate 、 N,N-二异丙基乙胺 、 N,N-二甲基羟胺 盐酸盐 在 碳酸氢钠 、 Brine 、 Sodium sulfate-III 、 petroleum ether EtOAc 作用下， 以 N,N-二甲基甲酰胺 、 乙酸乙酯 为溶剂， 反应 16.17h， 生成 (S)-tert-butyl 7-(((benzyloxy)carbonyl)amino)-8-(methoxy(methyl)amino)-8-oxooctanoate
  参考文献：
  名称：

  Compounds for use in the treatment of parasitic diseases

  摘要：

  本发明涉及用于治疗寄生虫病的化合物，这些疾病是由寄生虫引起或传播的传染性疾病。本发明的化合物特别活跃于疟疾的病原体。这些化合物是寄生虫组蛋白去乙酰化酶（PfHDAC）的选择性抑制剂，可以在比抑制哺乳动物细胞生长所需浓度更低的浓度下抑制寄生虫（如疟原虫）的生长。

  公开号：

  US09365541B2

文献信息

• Heterocycle Derivatives As Histone Deacetylase (Hdac) Inhibitors
  申请人：Attenni Barbara

  公开号：US20090048228A1

  公开（公告）日：2009-02-19

  The present invention relates to compounds of formula I: or pharmaceutically acceptable salts or tautomers thereof, which are inhibitors of histone deacetylase (HDAC). The compounds of the present invention are useful for treating cellular proliferative diseases, including cancer. Further, the compounds of the present invention are useful for treating neurodegenerative diseases, schizophrenia and stroke among other diseases.

  本发明涉及以下式I的化合物：或其药用可接受的盐或互变异构体，这些化合物是组蛋白去乙酰化酶（HDAC）的抑制剂。本发明的化合物可用于治疗细胞增殖性疾病，包括癌症。此外，本发明的化合物还可用于治疗神经退行性疾病、精神分裂症和中风等其他疾病。
• Hydroxamic acid compounds and methods of use thereof
  申请人：Breslow Ronald

  公开号：US20070155785A1

  公开（公告）日：2007-07-05

  The present invention relates to a novel class of hydroxamic acid derivatives having at least two aryl containing groups, at least one of which is a quinolinyl, isoquinolinyl or benzyl moiety, linked to the hydroxamic acid group through a methylene chain. The hydroxamic acid compounds can be used to treat cancer, for example, brain cancer. The hydroxamic acid compounds can also inhibit histone deacetylase and are suitable for use in selectively inducing terminal differentiation, and arresting cell growth and/or apoptosis of neoplastic cells, thereby inhibiting proliferation of such cells. Thus, the compounds of the present are useful in treating a patient having a tumor characterized by proliferation of neoplastic cells. The compounds of the invention are also useful in the prevention and treatment of TRX-mediated diseases, such as autoimmune, allergic and inflammatory diseases, and in the prevention and/or treatment of diseases of the central nervous system (CNS), such as neurodegenerative diseases.

  本发明涉及一种新型的羟肟酸衍生物，其至少具有两个含芳基团的结构，其中至少一个是喹啉基团、异喹啉基团或苄基团，通过亚甲基链连接到羟肟酸基团上。这些羟肟酸化合物可用于治疗癌症，例如脑癌。这些羟肟酸化合物还可以抑制组蛋白去乙酰化酶，并适用于选择性诱导末期分化、阻止肿瘤细胞生长和/或凋亡，从而抑制这些细胞的增殖。因此，本发明的化合物可用于治疗具有肿瘤细胞增殖特征的患者。该发明的化合物还可用于预防和治疗TRX介导的疾病，例如自身免疫、过敏和炎症性疾病，以及中枢神经系统（CNS）疾病的预防和/或治疗，例如神经退行性疾病。
• Chemokine Receptor Modulators
  申请人：Altiris Therapeutics, Inc

  公开号：US20130172330A1

  公开（公告）日：2013-07-04

  The invention provides compounds of Formula (I) and pharmaceutically acceptable salts, solvates, tautomers, stereoisomers, and/or esters thereof. These compounds, and pharmaceutical composition comprising such compounds are useful treating or preventing HIV infections, and in treating proliferative disorders such as inhibiting the metastasis of various cancers

  本发明提供了化合物I式及其药学上可接受的盐、溶剂合物、互变异构体、立体异构体和/或酯类。这些化合物和包含这些化合物的药物组合物可用于治疗或预防HIV感染，并用于治疗增殖性疾病，如抑制各种癌症的转移。
• COMPOUNDS FOR USE IN THE TREATMENT OF PARASITIC DISEASES
  申请人：IRBM - SCIENCE PARK S.P.A.

  公开号：US20150299163A1

  公开（公告）日：2015-10-22

  The present invention relates to compounds useful for treating parasitic diseases, which are infectious diseases caused or transmitted by a parasite. Compounds of the invention are particularly active against the causative pathogens in malaria. Such compounds are selective inhibitors of parasitic histone deacetylase (PfHDAC) and suppress the growth of parasites, such as Plasmodium falciparum , at a lower concentration than the concentration required for the inhibition of the growth of mammalian cells.

  本发明涉及用于治疗寄生虫病的化合物，这些疾病是由寄生虫引起或传播的传染病。本发明的化合物特别对疟疾病原体具有活性。这些化合物是寄生虫组蛋白去乙酰化酶(PfHDAC)的选择性抑制剂，可以在比抑制哺乳动物细胞生长所需浓度更低的浓度下抑制疟原虫等寄生虫的生长。
• HETEROCYCLE DERIVATIVES AS HISTONE DEACETYLASE (HDAC) INHIBITORS
  申请人：ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A.

  公开号：EP1828171B1

  公开（公告）日：2014-03-12