[4-(2-Hydroxy-ethyl)-5-pyrazin-2-yl-4H-[1,2,4]triazol-3-ylsulfanyl]-acetic acid hydrazide

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: [4-(2-Hydroxy-ethyl)-5-pyrazin-2-yl-4H-[1,2,4]triazol-3-ylsulfanyl]-acetic acid hydrazide
• 英文别名: 2-[[4-(2-Hydroxyethyl)-5-pyrazin-2-yl-1,2,4-triazol-3-yl]sulfanyl]acetohydrazide；2-[[4-(2-hydroxyethyl)-5-pyrazin-2-yl-1,2,4-triazol-3-yl]sulfanyl]acetohydrazide
• 化学式: C₁₀H₁₃N₇O₂S
• 分子量: 295.325
• InChiKey: WLPSOXLOCISYBV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.3
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  157
• 氢给体数：
  3
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  N'-(pyrazine-2-carbonyl)-hydrazinecarbodithioic acid methyl ester 在 氢氧化钾 、 一水合肼 作用下， 以 1,4-二氧六环 、 乙醇 为溶剂， 反应 2.0h， 生成 [4-(2-Hydroxy-ethyl)-5-pyrazin-2-yl-4H-[1,2,4]triazol-3-ylsulfanyl]-acetic acid hydrazide
  参考文献：
  名称：

  STUDIES ON PYRAZINE DERIVATIVES. XL. SYNTHESIS, REACTIVITY, AND TUBERCULOSTATIC ACTIVITY OF 4-HYDROXYALKYL-5-PYRAZINYL4H-[1,2,4]-TRIAZOLE-3-THIONES

  摘要：

  In the reactions of pirazinoyldithiocarbazoic acid monoester with aminoalcohols, 4-hydroxyalkyl-1,2,4-triazole-3-thiones were obtained. Their susceptibility to alkylation, as well as the condensed heterocyclic 1,3-thiazacycloalkyl[3,2-b]-1,2,4-thiazoles(1) formation ability, were examined. Some of the compounds obtained were tested for their tuberculostatic activity.

  DOI：

  10.1080/10426500490485534

文献信息

• STUDIES ON PYRAZINE DERIVATIVES. XL. SYNTHESIS, REACTIVITY, AND TUBERCULOSTATIC ACTIVITY OF 4-HYDROXYALKYL-5-PYRAZINYL4H-[1,2,4]-TRIAZOLE-3-THIONES
  作者：Henryk Foks、Mieczysław Janowiec、Zofia Zwolska、Ewa Augustynowicz-Kopeć

  DOI：10.1080/10426500490485534

  日期：2004.12.1

  In the reactions of pirazinoyldithiocarbazoic acid monoester with aminoalcohols, 4-hydroxyalkyl-1,2,4-triazole-3-thiones were obtained. Their susceptibility to alkylation, as well as the condensed heterocyclic 1,3-thiazacycloalkyl[3,2-b]-1,2,4-thiazoles(1) formation ability, were examined. Some of the compounds obtained were tested for their tuberculostatic activity.