Arphamenine A

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Arphamenine A
• 英文别名: (2R,5S)-5-amino-2-benzyl-8-(diaminomethylideneamino)-4-oxooctanoic acid
• 化学式: C₁₆H₂₄N₄O₃
• 分子量: 320.39
• InChiKey: FQRLGZIGRMSTAX-OLZOCXBDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.6
• 重原子数：
  23
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  145
• 氢给体数：
  4
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  (2R,5S)-2-benzyl-4-oxo-5-(phenylmethoxycarbonylamino)-8-[phenylmethoxycarbonyl-[(E)-N'-phenylmethoxycarbonylcarbamimidoyl]amino]octanoic acid 生成 Arphamenine A
  参考文献：
  名称：

  UMEZAWA, HAMAO;AOYAGI, TAKAAKI;TATSUTA, KUNIAKI;NAKAMURA, TAKESHI;FUKATSU+

  摘要：

  DOI：

文献信息

• COMPOSITIONS AND METHODS FOR USE OF A PROTEASE INHIBITOR AND ADENOSINE FOR PREVENTING ORGAN ISCHEMIA AND REPERFUSION INJURY
  申请人：EMORY UNIVERSITY

  公开号：EP1638579A2

  公开（公告）日：2006-03-29
• Compositions and methods for use of a protease inhibitor and adenosine for preventing organ ischemia and reperfusion injury
  申请人：Vinten-Johansen Jakob

  公开号：US20060205671A1

  公开（公告）日：2006-09-14

  Methods and compositions including combined use of a serine protease inhibitor and adenosine when administered as a single pharmaceutical composition, concomitantly or sequentially in any order to a living subject for preventing organ ischemia or reperfusion injury. The methods and compositions disclosed herein can be used in such procedures as cardiac surgery, non-surgical cardiac revascularization, organ transplantation, perfusion, ischemia, reperfusion, ischemia-reperfusion injury, oxidant injury, cytokine induced injury, shock induced injury, resuscitations injury or apoptosis.
• [EN] COMPOSITIONS AND METHODS FOR USE OF A PROTEASE INHIBITOR AND ADENOSINE FOR PREVENTING ORGAN ISCHEMIA AND REPERFUSION INJURY<br/>[FR] COMPOSITIONS ET METHODES D'UTILISATION D'UN INHIBITEUR DE PROTEASE ET D'UNE ADENOSINE DANS LA PREVENTION D'UNE ISCHEMIE ORGANIQUE ET D'UNE LESION DE REPERFUSION
  申请人：UNIV EMORY

  公开号：WO2005003150A2

  公开（公告）日：2005-01-13

  Methods and compositions including combined use of a serine protease inhibitor and adenosine when administered as a single pharmaceutical composition, concomitantly or sequentially in any order to a living subject for preventing organ ischemia or reperfusion injury. The methods and compositions disclosed herein can be used in such procedures as cardiac surgery, non-surgical cardiac revascularization, organ transplantation, perfusion, ischemia, reperfusion, ischemia-reperfusion injury, oxidant injury, cytokine induced injury, shock induced injury, resuscitations injury or apoptosis.