2-chloro-5-nitro-N-(pyridyl)benzamide | 136146-72-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-chloro-5-nitro-N-(pyridyl)benzamide
• 英文别名: 2-chloro-5-nitro-N-pyridin-2-ylbenzamide
• CAS: 136146-72-0
• 化学式: C₁₂H₈ClN₃O₃
• mdl: MFCD00805643
• 分子量: 277.667
• InChiKey: AOEJOAJTOWYAFP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  87.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  苯乙腈 、 2-chloro-5-nitro-N-(pyridyl)benzamide 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 1.0h， 以67%的产率得到3-Amino-7-nitro-4-phenyl-2-pyridin-2-yl-2H-isoquinolin-1-one
  参考文献：
  名称：

  3-Amino-4-aryl-1(2H)-isoquinolones

  摘要：

  DOI：

  10.1007/bf00474236

文献信息

• Methods and compositions for preserving tissues and organs
  申请人：Yarmush Martin L.

  公开号：US10575515B2

  公开（公告）日：2020-03-03

  The present invention generally relates to methods and compositions to determine viability of an organ for transplantation and other medical purposes. One aspect of the invention relates to a method for assessing the viability of an organ by measuring the energy parameters to determine the energy level of the organ by determining the stored cellular energy (e.g., ATP levels), and/or energy consumption over a particular time period of viability. The energy parameters can be compared to reference energy parameters as a highly accurate and reliable prediction of viable cell yield, and organ viability. Another aspect of the invention relates methods to preserve or extend the time period of viability of an organ any combination of (i) preservation perfusion of the organ to prevent ischemic damage, (ii) chemical metabolic suppression of the organ e.g., using metabolic suppressants, (iii) metabolic suppression by physical or environmental conditions, e.g., sub-zero non-freezing storage.

  本发明一般涉及确定用于移植和其他医疗目的的器官存活能力的方法和组合物。本发明的一个方面涉及一种评估器官存活能力的方法，该方法通过测量能量参数来确定器官的能量水平，具体方法是确定储存的细胞能量（如 ATP 水平）和/或存活特定时间段内的能量消耗。能量参数可与参考能量参数进行比较，从而高度准确可靠地预测存活细胞产量和器官存活率。本发明的另一个方面涉及保存或延长器官存活时间的方法，这些方法可以是以下方法的任意组合：(i) 对器官进行保存灌注以防止缺血性损伤；(ii) 对器官进行化学代谢抑制，例如使用代谢抑制剂；(iii) 通过物理或环境条件进行代谢抑制，例如零度以下的非冷冻储存。
• METHODS AND COMPOSITIONS FOR PRESERVING TISSUES AND ORGANS
  申请人：Yarmush Martin L.

  公开号：US20140030231A1

  公开（公告）日：2014-01-30

  The present invention generally relates to methods and compositions to determine viability of an organ for transplantation and other medical purposes. One aspect of the invention relates to a method for assessing the viability of an organ by measuring the energy parameters to determine the energy level of the organ by determining the stored cellular energy (e.g., ATP levels), and/or energy consumption over a particular time period of viability. The energy parameters can be compared to reference energy parameters as a highly accurate and reliable prediction of viable cell yield, and organ viability. Another aspect of the invention relates methods to preserve or extend the time period of viability of an organ any combination of (i) preservation perfusion of the organ to prevent ischemic damage, (ii) chemical metabolic suppression of the organ e.g., using metabolic suppressants, (iii) metabolic suppression by physical or environmental conditions, e.g., sub-zero non-freezing storage.
• [EN] USE OF PPARGAMMA SPECIFIC INHIBITORS AS ANTI-CANCER THERAPEUTICS<br/>[FR] UTILISATION D'INHIBITEURS SPECIFIQUES DES PPAR-GAMMA COMME AGENTS THERAPEUTIQUES ANTI-CANCEREUX
  申请人：BOSTON MEDICAL CT CORP

  公开号：WO2005077126A2

  公开（公告）日：2005-08-25

  The disclosed method is directed to the use of highly selective PPARϜ inhibitors and to siRNA specific for PPARϜ for treating a patient suffering from a disease or condition characterize by excessive cell proliferation. Exemplary cancers treatable by the method of the invention include, but are not limited to, epithelial cell tumors of the lung, liver, colon, breast or prostate such as human colorectal carcinoma and hepatocellular carcinoma; and lymphocyte-based cancers such as leukemia, lymphoma and multiple myeloma. The method of the invention would be particularly useful for prevention of metastasis, e.g., of epithelial cell tumors, and for reduction in the size of primary tumors or reduction of the rate of proliferation of abnormal lymphocytes or the rate of growth of epithelial precancerous lesions, such as colon cancer polyps. The method of the invention would also be useful for treating diseases characterized by excessive tissue growth such as scleroderma, systemic sclerosis, amyloidosis and gastrointestinal stromal tumors. This treatment could also be used as an immunosuppressant, for preventing the proliferation of lymphocytes. Preferred PPARϜ inhibitors useful in the method of the invention are those that covalently bond to PPARϜ and modify its activity, e.g., by reaction of a nitrogen group in the inhibitor with a cysteine residue in the PPARϜ binding pocket.
• [EN] METHODS AND COMPOSITIONS FOR PRESERVING TISSUES AND ORGANS<br/>[FR] PROCÉDÉS ET COMPOSITIONS POUR LA CONSERVATION DE TISSUS ET D'ORGANES
  申请人：GEN HOSPITAL CORP

  公开号：WO2011140241A2

  公开（公告）日：2011-11-10

  The present invention generally relates to methods and compositions to determine viability of an organ for transplantation and other medical purposes. One aspect of the invention relates to a method for assessing the viability of an organ by measuring the energy parameters to determine the energy level of the organ by determining the stored cellular energy (e.g., ATP levels), and/or energy consumption over a particular time period of viability. The energy parameters can be compared to reference energy parameters as a highly accurate and reliable prediction of viable cell yield, and organ viability. Another aspect of the invention relates methods to preserve or extend the time period of viability of an organ any combination of (i) preservation perfusion of the organ to prevent ischemic damage, (ii) chemical metabolic suppression of the organ e.g., using metabolic suppressants, (iii) metabolic suppression by physical or environmental conditions, e.g., sub-zero non-freezing storage.