N,N-succinyl-glutamic acid | 83556-30-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N,N-succinyl-glutamic acid
• 英文别名: N,N-Succinyl-glutaminsaeure；N-succinylglutamic acid；2-(2,5-dioxopyrrolidin-1-yl)pentanedioic acid
• CAS: 83556-30-3
• 化学式: C₉H₁₁NO₆
• 分子量: 229.189
• InChiKey: VVPXCQJEIWWMEH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.4
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  112
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 sodium hydroxide 作用下， 生成 N,N-succinyl-glutamic acid
  参考文献：
  名称：

  Abderhalden; Rindtorff; Schmitz, Fermentforschung, vol. 10, p. 214,225

  摘要：

  DOI：

文献信息

• TOLL-LIKE RECEPTOR MODULATORS AND TREATMENT OF DISEASES
  申请人：Carson Dennis A.

  公开号：US20100210598A1

  公开（公告）日：2010-08-19

  Provided herein are small molecule conjugates that are agonists or antagonists of one or more toll-like receptors.

  在此提供了一些小分子结合物，它们是一种或多种Toll样受体的激动剂或拮抗剂。
• Antagonists of the bradykinin B1 receptor
  申请人：Ng Gordon

  公开号：US20050215470A1

  公开（公告）日：2005-09-29

  The present invention relates to certain biologically active peptides and conjugated peptides which can be used as therapeutics or prophylactics against diseases or conditions linked to B1 as the causative agent. In a preferred embodiment of the invention biologically active PEG-conjugated peptides are provided. In one aspect of the present invention, pharmacologically active PEG-conjugated peptides of the present invention are useful to treat inflammation or pain.

  本发明涉及某些具有生物活性的肽和共轭肽，可用作治疗或预防与B1作为致病因素相关的疾病或病况的药物。在本发明的一个优选实施例中，提供了具有生物活性的PEG共轭肽。在本发明的一个方面中，本发明的药理活性PEG共轭肽可用于治疗炎症或疼痛。
• REACTIVE MULTI-ARM POLYMERS HAVING BRANCHED END GROUPS
  申请人：Boston Scientific Scimed Inc.

  公开号：US20210060183A1

  公开（公告）日：2021-03-04

  In some aspects, the present disclosure pertains to a polymer that comprises a plurality of polymer arms, wherein a first portion of the polymer arms comprise a reactive end group and wherein a second portion of the polymer arms comprise a branched end group that comprise a plurality of covalently attached diagnostic and/or therapeutic groups, which may be, for example, radiocontrast groups or radioactive groups. Other aspects pertain to a system that comprises (a) a first composition comprising such a polymer and (b) a second composition comprising a multifunctional compound that comprises reactive functional groups that are reactive with the reactive end group of the multi-arm polymer. Still other aspects pertain to a crosslinked reaction product of (a) such a polymer and (b) a multifunctional compound that comprises functional groups that are reactive with the reactive end group of the multi-arm polymer.

  在某些方面，本公开涉及一种聚合物，其包括多个聚合物臂，其中聚合物臂的第一部分包括反应性末端基团，聚合物臂的第二部分包括分支末端基团，该分支末端基团包括多个共价连接的诊断和/或治疗基团，例如放射对比剂或放射性基团。其他方面涉及一种系统，该系统包括（a）包含这种聚合物的第一组成份和（b）包含具有与多臂聚合物的反应性末端基团反应的反应性功能基团的多功能化合物的第二组成份。还有其他方面涉及（a）这种聚合物和（b）包含与多臂聚合物的反应性末端基团反应的功能性基团的多功能化合物的交联反应产物。
• GEL-FORMING COMPOSITION FOR MEDICAL USE, DEVICES FOR THE APPLICATION OF THE COMPOSITION, AND DRUG RELEASE CONTROLLING CARRIER
  申请人：Next21 K.K.

  公开号：EP1985283A1

  公开（公告）日：2008-10-29

  It is an object of the present invention to provide a gel-forming composition which permits on-site administration and can form a gel exhibiting prescribed strength and sustained drug release, devices for the administration thereof, and a kit for medical use. A gel-forming composition which is composed of the first composition comprising a drug, a first gelling agent represented by the general formula (I) and the like, and the first diluent and the second composition comprising the second gelling agent represented by the general formula (I) and the like and the second diluent; and application devices and kits for medical use, which can hold the gel-forming composition. X1 - (OCH2CH2)n - X2 (I) wherein X1 and X2 are each -R1COONHS (wherein R1 is C1-7 alkylene), -COR1COONHS, -NOCOR1-R2 (wherein R2 is maleimido), -R1NH2, -R1SH, or -CO2PhNO2, and n is an integer of 80 to 1000.

  本发明的目的是提供一种允许现场给药并能形成具有规定强度和持续释药的凝胶的凝胶形成组合物、其给药装置和医疗用试剂盒。一种凝胶形成组合物，它由包含药物、通式（I）代表的第一胶凝剂和类似物以及第一稀释剂的第一组合物和包含通式（I）代表的第二胶凝剂和类似物以及第二稀释剂的第二组合物组成；以及可容纳凝胶形成组合物的施用装置和医疗用试剂盒。X1-(OCH2CH2)n-X2(I) 其中X1和X2各自为-R1COONHS(其中R1为C1-7亚烷基)、-COR1COONHS、-NOCOR1-R2(其中R2为马来酰亚胺基)、-R1NH2、-R1SH或-CO2PhNO2，且n为80至1000的整数。
• Toll-like receptor modulators and treatment of diseases
  申请人：The Regents of The University of California

  公开号：EP2607365A1

  公开（公告）日：2013-06-26

  Provided herein are small molecule conjugates that are agonists or antagonists of one or more toll-like receptors.

  本文提供的小分子共轭物是一种或多种收费样受体的激动剂或拮抗剂。