trisodium;[[[3,4-dihydroxy-5-(4-oxido-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl] phosphate

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷酸
• 英文名称: trisodium;[[[3,4-dihydroxy-5-(4-oxido-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl] phosphate
• 化学式: C9H12N2Na3O15P3
• 分子量: 550.09
• InChiKey: MMJGIWFJVDOPJF-UHFFFAOYSA-K

计算性质

• 辛醇/水分配系数(LogP)：
  -13.38
• 重原子数：
  32
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  267
• 氢给体数：
  4
• 氢受体数：
  15

反应信息

• 作为反应物：
  描述：

  trisodium;[[[3,4-dihydroxy-5-(4-oxido-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl] phosphate 、 三正丁胺 在 resultant solution 、 N,N-二甲基甲酰胺 作用下， 以 水 为溶剂， 以to thereby yield a 0.133 M dimethylformamide solution of UTP tributylamine salt的产率得到uridine 5'-triphosphate tri-n-butylamine salt
  参考文献：
  名称：

  PROCESS FOR PRODUCING DI(PYRIMIDINE NUCLEOSIDE 5'-)POLYPHOSPHATE

  摘要：

  通过使用缩合剂将嘧啶核苷酸5'-三磷酸转化为嘧啶核苷酸5'-环三磷酸，然后在镁、锰、铁盐的存在下将嘧啶核苷酸5'-环三磷酸与嘧啶核苷酸反应，可以合成一种嘧啶核苷酸5'-二聚磷酸。该发明方法可以从未保护的嘧啶核苷酸5'-磷酸作为起始物质开始合成，合成产率达到50%或更高。因此，该发明方法适用于大规模合成嘧啶核苷酸5'-二聚磷酸。

  公开号：

  US20100016567A1

文献信息

• Process for producing di(pyrimidine nucleoside 5'-)polyphosphate
  申请人：Yamasa Corporation

  公开号：US08193338B2

  公开（公告）日：2012-06-05

  A di(pyrimidine nucleoside 5′-)polyphosphate is synthesized by converting a pyrimidine nucleoside 5′-triphosphate into a pyrimidine nucleoside 5′-cyclic triphosphate by use of a condensing agent, and subsequently reacting the pyrimidine nucleoside 5′-cyclic triphosphate with a pyrimidine nucleotide in the presence of a salt of a metal selected from among magnesium, manganese, and iron. Through the method of the invention, a di(pyrimidine nucleoside 5′-)polyphosphate can be synthesized from an unprotected pyrimidine nucleoside 5′-phosphate serving as a starting material at a synthesis yield of 50% or higher. Therefore, the method of the invention is suitable for large-scale synthesis of a di(pyrimidine nucleoside 5′-)polyphosphate.

  通过使用缩合剂将嘧啶核苷酸5'-三磷酸转化为嘧啶核苷酸5'-环三磷酸，然后在镁、锰、铁等金属盐的存在下将嘧啶核苷酸5'-环三磷酸与嘧啶核苷酸反应，可以合成一种二(嘧啶核苷酸5'-)聚磷酸。通过本发明的方法，可以从作为起始物的未保护的嘧啶核苷酸5'-磷酸合成出50％或更高的产率的二(嘧啶核苷酸5'-)聚磷酸。因此，本发明的方法适用于大规模合成二(嘧啶核苷酸5'-)聚磷酸。
• PROCESS FOR PRODUCING DI(PYRIMIDINE NUCLEOSIDE 5'-)POLYPHOSPHATE
  申请人：Kogo Satoru

  公开号：US20100016567A1

  公开（公告）日：2010-01-21

  A di(pyrimidine nucleoside 5′-)polyphosphate is synthesized by converting a pyrimidine nucleoside 5′-triphosphate into a pyrimidine nucleoside 5′-cyclic triphosphate by use of a condensing agent, and subsequently reacting the pyrimidine nucleoside 5′-cyclic triphosphate with a pyrimidine nucleotide in the presence of a salt of a metal selected from among magnesium, manganese, and iron. Through the method of the invention, a di(pyrimidine nucleoside 5′-)polyphosphate can be synthesized from an unprotected pyrimidine nucleoside 5′-phosphate serving as a starting material at a synthesis yield of 50% or higher. Therefore, the method of the invention is suitable for large-scale synthesis of a di(pyrimidine nucleoside 5′-)polyphosphate.

  通过使用缩合剂将嘧啶核苷酸5'-三磷酸转化为嘧啶核苷酸5'-环三磷酸，然后在镁、锰、铁盐的存在下将嘧啶核苷酸5'-环三磷酸与嘧啶核苷酸反应，可以合成一种嘧啶核苷酸5'-二聚磷酸。该发明方法可以从未保护的嘧啶核苷酸5'-磷酸作为起始物质开始合成，合成产率达到50%或更高。因此，该发明方法适用于大规模合成嘧啶核苷酸5'-二聚磷酸。

表征谱图