2-(3-amino-5-fluorophenyl)acetonitrile

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(3-amino-5-fluorophenyl)acetonitrile
• 英文别名: (3-Amino-5-fluorophenyl)acetonitrile
• 化学式: C₈H₇FN₂
• 分子量: 150.155
• InChiKey: UKBRLOMWKQCBCA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  49.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(3-amino-5-fluorophenyl)acetonitrile 在 氨 、 氢气 作用下， 以 四氢呋喃 、 水 为溶剂， 25.0 ℃ 、344.75 kPa 条件下， 生成 3-(2-aminoethyl)-5-fluoroaniline
  参考文献：
  名称：

  [EN] PYRAZINE COMPOUNDS AS IRREVERSIBLE INHIBITORS OF FLT3
  [FR] COMPOSÉS DE PYRAZINE EN TANT QU'INHIBITEURS IRRÉVERSIBLES DE FLT3

  摘要：

  Disclosed herein are heterocyclic compounds that inhibit the activity of FLT3. Also described are specific irreversible inhibitors of FLT3. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the FLT3 inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of proliferative diseases or conditions, including hematological malignancies and other diseases or conditions dependent on FLT3 activity.

  公开号：

  WO2023027966A1
• 作为产物：
  描述：

  tert-butyl (3-(cyanomethyl)-5-fluorophenyl)carbamate 在 盐酸 作用下， 以 乙酸乙酯 为溶剂， 生成 2-(3-amino-5-fluorophenyl)acetonitrile
  参考文献：
  名称：

  [EN] PYRAZINE COMPOUNDS AS IRREVERSIBLE INHIBITORS OF FLT3
  [FR] COMPOSÉS DE PYRAZINE EN TANT QU'INHIBITEURS IRRÉVERSIBLES DE FLT3

  摘要：

  Disclosed herein are heterocyclic compounds that inhibit the activity of FLT3. Also described are specific irreversible inhibitors of FLT3. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the FLT3 inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of proliferative diseases or conditions, including hematological malignancies and other diseases or conditions dependent on FLT3 activity.

  公开号：

  WO2023027966A1

文献信息

• [EN] FLT3 COMBINATION THERAPY FOR CANCER AND COMPOSITIONS THEREFOR<br/>[FR] POLYTHÉRAPIE À BASE DE FLT3 POUR LE CANCER ET COMPOSITIONS ASSOCIÉES
  申请人：[en]BIOMEA FUSION, INC.

  公开号：WO2023225005A1

  公开（公告）日：2023-11-23

  Disclosed herein are combinations comprising an inhibitor of FLT3 and an inhibitor of menin. Also described are combinations of specific irreversible inhibitors of FLT3 and irreversible inhibitors of menin. Also described are methods of using the combinations for the treatment of proliferative diseases or conditions, including hematological malignancies and other diseases or conditions dependent on FLT3 activity.