5-bromo-2-chloro-6-fluoro-1H-imidazo[4,5-b]pyridine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并吡啶类
• 英文名称: 5-bromo-2-chloro-6-fluoro-1H-imidazo[4,5-b]pyridine
• 化学式: C₆H₂BrClFN₃
• 分子量: 250.457
• InChiKey: JGDXUCLIIVKEFR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  41.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  5-bromo-2-chloro-6-fluoro-1H-imidazo[4,5-b]pyridine 在 caesium carbonate 、 三乙胺 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 为溶剂， 反应 13.5h， 生成 methyl 5-((5-bromo-6-fluoro-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazo[4,5-b]pyridin-2-yl)oxy)-2-methylbenzoate
  参考文献：
  名称：

  [EN] AMPK ACTIVATORS
  [FR] ACTIVATEURS DE L'AMPK

  摘要：

  This disclosure is directed, at least in part, to AMPK activators useful for the treatment of conditions or disorders associated with AMPK. In some embodiments, the condition or disorder is associated with the gut-brain axis. In some embodiments, condition or disorder is associated with systemic infection and inflammation from having a leaky gut barrier. In some embodiments, the AMPK activators are gut-restricted compounds. In some embodiments, the AMPK activators are agonists, super agonists, full agonists, or partial agonists.

  公开号：

  WO2023097187A1
• 作为产物：
  描述：

  C₆H₃BrFN₃O 在 三氯氧磷 作用下， 生成 5-bromo-2-chloro-6-fluoro-1H-imidazo[4,5-b]pyridine
  参考文献：
  名称：

  [EN] AMPK ACTIVATORS
  [FR] ACTIVATEURS DE L'AMPK

  摘要：

  This disclosure is directed, at least in part, to AMPK activators useful for the treatment of conditions or disorders associated with AMPK. In some embodiments, the condition or disorder is associated with the gut-brain axis. In some embodiments, condition or disorder is associated with systemic infection and inflammation from having a leaky gut barrier. In some embodiments, the AMPK activators are gut-restricted compounds. In some embodiments, the AMPK activators are agonists, super agonists, full agonists, or partial agonists.

  公开号：

  WO2023097187A1

文献信息

• AZABENZIMIDAZOLE DERIVATIVE HAVING AMPK-ACTIVATING ACTIVITY
  申请人：Shionogi & Co., Ltd.

  公开号：EP2733141A1

  公开（公告）日：2014-05-21

  Disclosed is a compound which is useful as an AMPK activator. A compound represented by formula: or a pharmaceutically acceptable salt thereof, wherein R4 is hydrogen, or substituted or unsubstituted alkyl, R1, R2 and R3 are each independently hydrogen, halogen, hydroxy, cyano, nitro, carboxy, substituted or unsubstituted alkyl or the like, with the proviso that R1, R2 and R3 are not simultaneously hydrogen, X is a single bond, -S-, -O-, -NR5-, -C(=O)- or the like, R5 is hydrogen, or substituted or unsubstituted alkyl, Y is substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted heterocyclyl or the like.

  本发明公开了一种可用作 AMPK 激活剂的化合物。 一种由式表示的化合物： 或其药学上可接受的盐、 其中 R4 是氢、或取代或未取代的烷基、 R1、R2 和 R3 各自独立地为氢、卤素、羟基、氰基、硝基、羧基、取代或未取代的烷基或类似物，但 R1、R2 和 R3 不能同时为氢、 X 是单键、-S-、-O-、-NR5-、-C(=O)- 等、 R5 是氢、取代或未取代的烷基、 Y 是取代或未取代的环烷基、取代或未取代的环烯基、取代或未取代的杂环基等。
• US9567330B2
  申请人：——

  公开号：US9567330B2

  公开（公告）日：2017-02-14
• [EN] AMPK ACTIVATORS<br/>[FR] ACTIVATEURS DE L'AMPK
  申请人：[en]KALLYOPE, INC.

  公开号：WO2023097187A1

  公开（公告）日：2023-06-01

  This disclosure is directed, at least in part, to AMPK activators useful for the treatment of conditions or disorders associated with AMPK. In some embodiments, the condition or disorder is associated with the gut-brain axis. In some embodiments, condition or disorder is associated with systemic infection and inflammation from having a leaky gut barrier. In some embodiments, the AMPK activators are gut-restricted compounds. In some embodiments, the AMPK activators are agonists, super agonists, full agonists, or partial agonists.