(4R)-4-amino-5-[[(1R)-1-carboxy-2-(1H-indol-3-yl)ethyl]amino]-5-oxopentanoic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (4R)-4-amino-5-[[(1R)-1-carboxy-2-(1H-indol-3-yl)ethyl]amino]-5-oxopentanoic acid
• 化学式: C₁₆H₁₉N₃O₅
• 分子量: 333.34
• InChiKey: LLEUXCDZPQOJMY-DGCLKSJQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.7
• 重原子数：
  24
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  146
• 氢给体数：
  5
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  thymodepressin 、 (4R)-4-amino-5-[[(1R)-1-carboxy-2-(1H-indol-3-yl)ethyl]amino]-5-oxopentanoic acid 生成 D-isoglutamyl-D-tryptophan
  参考文献：
  名称：

  Crystalline forms of the mono-sodium salt of D-isoglutamyl-D-tryptophan

  摘要：

  本发明涉及D-异谷氨酰-D-色氨酸单钠盐的晶体形式、包含它们的制药组合物、它们在治疗各种疾病和病情中的应用以及它们的制备方法。具体而言，本发明涉及D-异谷氨酰-D-色氨酸单钠盐的晶体修饰1（多形式F）。

  公开号：

  US08592607B2

文献信息

• CRYSTALLINE D-ISOGLUTAMYL-D-TRYPTOPHAN AND THE MONO AMMONIUM SALT OF D-ISOGLUTAMYL-D-TRYPTOPHAN
  申请人：Tam Tim Fat

  公开号：US20100016243A1

  公开（公告）日：2010-01-21

  A process for making pure crystalline D-isoglutamyl-D-tryptophan is provided which includes the step of deprotecting essentially pure N-tert-butoxycarbonyl-D-isoglutamyl-D-tryptophan or its diester to yield essentially pure D-isoglutamyl-D-tryptophan. A process is also provided for the preparation of pure mono ammonium salt of D-isoglutamyl-D-tryptophan from essentially pure N-tert-butoxycarbonyl-D-isoglutamyl-D-tryptophan. D-isoglutamyl-D-tryptophan, ammonium salt (1:1) is a stable pharmaceutical solid.

  提供了一种制备纯结晶D-异戊氨酰-D-色氨酸的过程，包括去保护基本纯的N-叔丁氧羰基-D-异戊氨酰-D-色氨酸或其二酯的步骤，以得到基本纯的D-异戊氨酰-D-色氨酸。还提供了一种从基本纯的N-叔丁氧羰基-D-异戊氨酰-D-色氨酸制备纯D-异戊氨酰-D-色氨酸单铵盐的过程。D-异戊氨酰-D-色氨酸，铵盐（1:1）是一种稳定的药用固体。
• CRYSTALLINE FORMS OF THE MONO-SODIUM SALT OF D-ISOGLUTAMYL-D-TRYPTOPHAN
  申请人：Tam Tim Fat

  公开号：US20100029742A1

  公开（公告）日：2010-02-04

  The present invention relates to crystalline forms of the mono-sodium salt of D-isoglutamyl-D-tryptophan, pharmaceutical compositions comprising them, their use in the treatment of various diseases and conditions, and processes for their preparation. In particular, the present invention relates the crystal modification 1 (polymorphic form F), the crystal modification 2 (polymorphic form I), and the crystal modification 3 (polymorphic form X) of the mono-sodium salt of D-isoglutamyl-D-tryptophan.

  本发明涉及D-异谷氨酰-D-色氨酸单钠盐的结晶形式，包括它们的药物组合物，它们在治疗各种疾病和病况中的应用，以及它们的制备方法。具体来说，本发明涉及D-异谷氨酰-D-色氨酸单钠盐的晶体改性1（多形式F）、晶体改性2（多形式I）和晶体改性3（多形式X）。
• CRYSTALLINE D-ISOGLUTAMYL-D-TRYPTOPHAN AND THE MONO AMMONIUM SLAT OF D-ISOGLUTAMYL-D-TRYPTOPHAN
  申请人：TAM Tim Fat

  公开号：US20130059791A1

  公开（公告）日：2013-03-07

  A process for making pure crystalline D-isoglutamyl-D-tryptophan is provided which includes the step of deprotecting essentially pure N-tert-butoxycarbonyl-D-isoglutamyl-D-tryptophan or its diester to yield essentially pure D-isoglutamyl-D-tryptophan. A process is also provided for the preparation of pure mono ammonium salt of D-isoglutamyl-D-tryptophan from essentially pure N-tert-butoxycarbonyl-D-isoglutamyl-D-tryptophan. D-isoglutamyl-D-tryptophan, ammonium salt (1:1) is a stable pharmaceutical solid.

  提供了一种制备纯结晶D-异谷氨酰-D-色氨酸的过程，包括去保护基的步骤，将基本上纯的N-叔丁氧羰基-D-异谷氨酰-D-色氨酸或其二酯去保护，得到基本上纯的D-异谷氨酰-D-色氨酸。还提供了一种从基本上纯的N-叔丁氧羰基-D-异谷氨酰-D-色氨酸制备纯D-异谷氨酰-D-色氨酸单酰胺盐的过程。D-异谷氨酰-D-色氨酸铵盐（1:1）是一种稳定的药物固体。
• CRYSTALLINE D-ISOGLUTAMYL-D-TRYPTOPHAN AND THE MONO AMMONIUM SALT OF D-ISOGLUTAMYL- D-TRYPTOPHAN
  申请人：Apotex Technologies Inc.

  公开号：EP2121728A1

  公开（公告）日：2009-11-25
• US8119606B2
  申请人：——

  公开号：US8119606B2

  公开（公告）日：2012-02-21