3,3,5,5-tetramethyl-2,3,4,5-tetrahydro-1H-2-benzazepine | 445265-39-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯氮卓类
• 英文名称: 3,3,5,5-tetramethyl-2,3,4,5-tetrahydro-1H-2-benzazepine
• 英文别名: 3,3,5,5-tetramethyl-2,4-dihydro-1H-2-benzazepine
• CAS: 445265-39-4
• 化学式: C₁₄H₂₁N
• mdl: MFCD02925212
• 分子量: 203.327
• InChiKey: REIQGKWQWULFIW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  15
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.571
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3,3,5,5-tetramethyl-2,3,4,5-tetrahydro-1H-2-benzazepine 在 sodium tungstate 、 双氧水 作用下， 以 水 、 丙酮 为溶剂， 以55%的产率得到3,3,5,5-tetramethyl-2-oxido-4H-2-benzazepin-2-ium
  参考文献：
  名称：

  Inhibition of 6-hydroxydopamine-induced oxidative damage by 4,5-dihydro-3H-2-benzazepine N-oxides

  摘要：

  A number of new analogs of 3,3-dimethyl-4,5-dihydro-3H-2-benzazepine 2-oxide, structurally related to the nitrone spin trap alpha-phenyl-N-tert-butylnitrone (PBN), were synthesized and evaluated for their activity in vitro as protectants against oxidative stress induced in rat brain mitochondria by 6-hydroxydopamine (6-OHDA), a neurotoxin producing experimental model of Parkinson's disease (PD). As assessed by a fluorimetric assay, all 2-benzazepine-based nitrones were shown to decrease hydroxyl radicals (center dot OH) generated during 6-OHDA autoxidation. The inhibition effects on the center dot OH formation shown by the 5-gem-dimethyl derivatives, 2-4 times higher than those of the corresponding 5-methyl derivatives, were attributed to the flattening effect of the 5-gem-dimethyl group on the azepine ring, which should enhance nitrone reactivity and/or increase stability of the radical adducts. In contrast, owing to steric hindrance, a methyl group to C-1 diminishes the center dot OH-scavenging activity of the nitrone group. All the assayed compounds were more potent than PBN as inhibitors of 6-OHDA-induced lipid peroxidation (LPO) and protein carbonylation (PCO), taken as an indicator of mitochondrial protein oxidative damage. The most promising antioxidant (compound 11), bearing 5-gem-dimethyl and spiro C-3 cyclohexyl groups, highlighted in this study as the best features, inhibited LPO and PCO with IC50 values of 20 and 48 mu M, respectively, showing a potency improvement over PBN of two order magnitude. Both LPO and PCO inhibition potency data were found primarily related to the center dot OH-scavenging activities, whereas lipophilicity plays a role in improving the LPO (but not PCO) inhibition, as a statistically valuable two-parameter equation proved. (c) 2008 Elsevier Inc. All rights reserved.

  DOI：

  10.1016/j.bcp.2007.12.010

文献信息

• Conversion of 2-ethyl-3,3,5,5-tetramethyl- and 2-ethyl-1,3,3,5,5-pentamethyl-1,2,4,5-tetra-hydro-3h-benz-2-azepines by the action of ethyl propiolate
  作者：L. G. Voskressensky、T. N. Borisova、E. A. Sorokina、L. N. Kulikova、A. V. Kleimenov、S. V. Tolkunov、A. V. Varlamov

  DOI：10.1007/s10593-010-0414-4

  日期：2009.10

  It has been shown that, on interacting 2-ethyl-3,3,5,5-tetramethyl- and 2-ethyl-1,3,3,5,5-pentamethyl-1,2,4,5-tetrahydro-3H-benz-2-azepines with ethyl propiolate in methanol, fission of the azepine ring occurs at the C(1)–N(2) bond involving a molecule of solvent. The indicated azepines do not react with acetylenedicarboxylic acid ester under these conditions.

  已经表明，在相互作用的2-乙基-3,3,5,5-四甲基-和2-乙基-1,3,3,5,5-五甲基-1,2,4,5-四氢-3H上-benz-2-azpinepines与丙酸乙酯在甲醇中，zezpine环的裂变发生在涉及溶剂分子的C（1）–N（2）键处。在这些条件下，所示的a庚烷不与乙炔二羧酸酯反应。
• Inhibition of 6-hydroxydopamine-induced oxidative damage by 4,5-dihydro-3H-2-benzazepine N-oxides
  作者：Ramón Soto-Otero、Estefanía Méndez-Álvarez、Sofía Sánchez-Iglesias、Fedor I. Zubkov、Leonid G. Voskressensky、Alexey V. Varlamov、Modesto de Candia、Cosimo Altomare

  DOI：10.1016/j.bcp.2007.12.010

  日期：2008.4

  A number of new analogs of 3,3-dimethyl-4,5-dihydro-3H-2-benzazepine 2-oxide, structurally related to the nitrone spin trap alpha-phenyl-N-tert-butylnitrone (PBN), were synthesized and evaluated for their activity in vitro as protectants against oxidative stress induced in rat brain mitochondria by 6-hydroxydopamine (6-OHDA), a neurotoxin producing experimental model of Parkinson's disease (PD). As assessed by a fluorimetric assay, all 2-benzazepine-based nitrones were shown to decrease hydroxyl radicals (center dot OH) generated during 6-OHDA autoxidation. The inhibition effects on the center dot OH formation shown by the 5-gem-dimethyl derivatives, 2-4 times higher than those of the corresponding 5-methyl derivatives, were attributed to the flattening effect of the 5-gem-dimethyl group on the azepine ring, which should enhance nitrone reactivity and/or increase stability of the radical adducts. In contrast, owing to steric hindrance, a methyl group to C-1 diminishes the center dot OH-scavenging activity of the nitrone group. All the assayed compounds were more potent than PBN as inhibitors of 6-OHDA-induced lipid peroxidation (LPO) and protein carbonylation (PCO), taken as an indicator of mitochondrial protein oxidative damage. The most promising antioxidant (compound 11), bearing 5-gem-dimethyl and spiro C-3 cyclohexyl groups, highlighted in this study as the best features, inhibited LPO and PCO with IC50 values of 20 and 48 mu M, respectively, showing a potency improvement over PBN of two order magnitude. Both LPO and PCO inhibition potency data were found primarily related to the center dot OH-scavenging activities, whereas lipophilicity plays a role in improving the LPO (but not PCO) inhibition, as a statistically valuable two-parameter equation proved. (c) 2008 Elsevier Inc. All rights reserved.