4-(3-(2-methoxyphenyl)allyl)morpholine | 101114-47-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 4-(3-(2-methoxyphenyl)allyl)morpholine
• 英文别名: 3-Morpholino-1-(2-methoxy-phenyl)-propen-(1)；4-[3-(2-Methoxyphenyl)prop-2-enyl]morpholine
• CAS: 101114-47-0
• 化学式: C₁₄H₁₉NO₂
• 分子量: 233.31
• InChiKey: QHDQCPYBAQHRHA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  21.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  吗啉 、 顺-2-甲氧基肉桂酸 在 聚合甲醛 作用下， 以 水 为溶剂， 反应 12.0h， 以37%的产率得到4-(3-(2-methoxyphenyl)allyl)morpholine
  参考文献：
  名称：

  Additive-Free Decarboxylative Coupling of Cinnamic Acid Derivatives in Water: Synthesis of Allyl Amines

  摘要：

  The first example of an additive-free decarboxylative coupling of cinnamic acid derivatives with formaldehyde and amines to afford the corresponding allyl amines is reported. This reaction is highly environmentally friendly because it was conducted in H2O and without any additives, releasing only CO2 and H2O as byproducts. This reaction showed a broad substrate scope including cyclic and acyclic amines and high functional group tolerance. Moreover, phenyl dienoic acid participated in this type of decarboxylative coupling reaction.

  DOI：

  10.1021/acs.orglett.5b00303

文献信息

• Additive-Free Decarboxylative Coupling of Cinnamic Acid Derivatives in Water: Synthesis of Allyl Amines
  作者：Kyungho Park、Sunwoo Lee

  DOI：10.1021/acs.orglett.5b00303

  日期：2015.3.6

  The first example of an additive-free decarboxylative coupling of cinnamic acid derivatives with formaldehyde and amines to afford the corresponding allyl amines is reported. This reaction is highly environmentally friendly because it was conducted in H2O and without any additives, releasing only CO2 and H2O as byproducts. This reaction showed a broad substrate scope including cyclic and acyclic amines and high functional group tolerance. Moreover, phenyl dienoic acid participated in this type of decarboxylative coupling reaction.