(+)-Hydroxypanduratin A

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二芳基庚烷
• 英文名称: (+)-Hydroxypanduratin A
• 英文别名: (-)-(2,4,6-trihydroxyphenyl)[3'-methyl-2'-(3''-methylbut-2''-enyl)-6'-phenylcyclohex-3'-enyl]methanone；4-hydroxypanduratin A；[(1R,2S,6R)-3-methyl-2-(3-methylbut-2-enyl)-6-phenylcyclohex-3-en-1-yl]-(2,4,6-trihydroxyphenyl)methanone
• 化学式: C₂₅H₂₈O₄
• 分子量: 392.495
• InChiKey: AYPOOQWQTQIRFW-ZRCGQRJVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  29
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  77.8
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  硫酸二甲酯 、 (+)-Hydroxypanduratin A 在 potassium carbonate 作用下， 以 丙酮 为溶剂， 反应 24.0h， 生成 (1'RS,2'SR,6'RS)-(2,4,6-trimethoxyphenyl)<3'-methyl-2'-(3"-methylbut-2"-enyl)-6'-phenylcyclohex-3'-enyl>-methanone
  参考文献：
  名称：

  Anti-inflammatory cyclohexenyl chalcone derivatives in Boesenbergia pandurata

  摘要：

  The cyclohexenyl chalcone derivative [(-)-hydroxypanduratin A], together with the previously known panduratin A, sakuranetin, pinostrobin, pinocembrin, and dihydro-5,6-dehydrokawain were isolated from the chloroform extract of the red rhizome variety of Boesenbergia pandurata (Robx.) Schltr. [currently known as Boesenbergia rotunda (L.) Mansf., Kulturpfl.]. Their structures were assigned on the basis of their spectroscopic data. (-)-Hydroxypanduratin A and (-)-panduratin A showed significant topical anti-inflammatory activity in the assay of TPA-induced ear edema in rats. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0031-9422(01)00451-4

文献信息

• NOVEL USE OF PANDURATIN DERIVATIVE OR BOESENBERGIA PANDURATA EXTRACT
  申请人：Hwang Jae-Kwan

  公开号：US20120088840A1

  公开（公告）日：2012-04-12

  The present invention relates to a novel use of a panduratin derivative or a Boesenbergia pandurata extract. More specifically, the invention relates to a composition for preventing and treating/relieving a metabolic disease selected from a group consisting of obesity, hyperlipidemia, hypercholesterolemia and diabetes, containing a panduratin derivative represented by Chemical Formula 1, 2 or 3 or a Boesenbergia pandurata extract as an active ingredient, a method for treating a metabolic disease selected from a group consisting of obesity, hyperlipidemia, hypercholesterolemia and diabetes, by administering an effective amount of the panduratin derivative or the Boesenbergia pandurata extract to a subject in need thereof, and a use of the panduratin derivative or the Boesenbergia pandurata extract to prepare a reagent for preventing and treating/relieving a metabolic disease selected from a group consisting of obesity, hyperlipidemia, hypercholesterolemia and diabetes. As can be seen foregoing, the present invention provides a novel use of a panduratin derivative or a Boesenbergia pandurata extract. A panduratin derivative or a Boesenbergia pandurata extract of the present invention shows excellent effects on a metabolic disease such as obesity, hyperlipidemia, hypercholesterolemia and diabetes by decreasing highly related causes of metabolic diseases such as on weight, body fat and lipid-content. Since a composition of the present invention is originated from natural materials, it can be used without side effect and provides novel method for preventing and treating/relieving a metabolic disease through body weight loss and body fat loss and the like.
• NOVEL USE OF PANDURATIN DERIVATIVES OR EXTRACT OF KAEMPFERIA PANDURATA COMPRISING THE SAME
  申请人：Hwang Jae Kwan

  公开号：US20120065272A1

  公开（公告）日：2012-03-15

  The present invention relates to a new use of panduratin derivatives or a Kaempferia pandurata extract comprising the same. More particularly, the present invention relates to a composition for improving wrinkles and/or preventing aging, which comprises a panduratin derivative or a Kaempferia pandurata extract comprising the same. The said the panduratin derivative or the Kaempferia pandurata extract comprising the same induces cell proliferation, inhibits degradation of collagen, and promotes synthesis of collagen, therefore, it shows excellent activity in prevention of aging, particularly preventing, improving or treating wrinkle and it can be used as an effective ingredient in a cosmetic, food or pharmaceutical composition.
• US8653143B2
  申请人：——

  公开号：US8653143B2

  公开（公告）日：2014-02-18
• US9198880B2
  申请人：——

  公开号：US9198880B2

  公开（公告）日：2015-12-01
• [EN] ANTI-HALITOSIS COMPOSITION COMPRISING PANDURATIN DERIVATIVES<br/>[FR] COMPOSITION ANTI-HALITOSE COMPORTANT DES DÉRIVÉS DE PANDURATINE
  申请人：HWANG JAE-KWAN

  公开号：WO2010041777A1

  公开（公告）日：2010-04-15

  An anti-halitosis composition comprising a panduratin derivative or Boesenbergia pandurata extract as an active ingredient, and an anti-halitosis composition comprising an emulsified panduratin derivative or Boesenbergia pandurata extract as an active ingredient. The compositions may be safely applied to the buccal cavity without side effects and have high anti-halitosis effects. In particular, the anti-halitosis composition comprising the emulsified panduratin derivative or Boesenbergia pandurata extract as an active ingredient may be applied to a variety of products including liquid food products.

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