Phosphorsaeure-bis-aethylenamid-<2-iod-benzoylamid> | 4119-81-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Phosphorsaeure-bis-aethylenamid-<2-iod-benzoylamid>
• 英文别名: Phosphorsaeure-diaethylenamid-<2-iod-benzoylamid>；N-(bis-aziridin-1-yl-phosphinoyl)-2-iodo-benzamide；Iodobenzotef；N-[bis(aziridin-1-yl)phosphoryl]-2-iodobenzamide
• CAS: 4119-81-7
• 化学式: C₁₁H₁₃IN₃O₂P
• 分子量: 377.121
• InChiKey: WLEFRRNVWGUEIP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  52.2
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  Phosphorsaeure-bis-aethylenamid-<2-iod-benzoylamid> 、 甲基丙烯酸丁酯 在 氮气 作用下， 以 水 为溶剂， 反应 0.5h， 以The monomer mixture is obtained by the addition of 585 g of styrene 225 g of butyl methacrylate, and 90 g of methyl methacrylate in a 2 liter Erlermeyer flask with magnetic stirring的产率得到苯乙烯
  参考文献：
  名称：

  Method for the production of high concentrations of emulsion polymers

  摘要：

  公开了一种制备固体含量约65％至约80％的乳液聚合物的方法。该方法包括将单体混合物添加到维持在约60℃至约90℃的反应系统中，单体添加速率不超过总单体的四分之一每小时，混合物包括粒径约为10-100微米的单体，系统在单体添加时含有乳化剂和引发剂。

  公开号：

  US04418183A1
• 作为试剂：
  描述：

  Turbostatin 1 、 Turbostatin 2 在 Phosphorsaeure-bis-aethylenamid-<2-iod-benzoylamid> 、 水合甲醇 作用下， 反应 0.76h， 以Turbostatins 1 and 2 were obtained in the following order的产率得到Turbostatin 4
  参考文献：
  名称：

  Isolation and structure of turbostatins 1-4

  摘要：

  本文描述了一种新的神经鞘脂化合物，分别命名为Turbostatin 1、Turbostatin 2、Turbostatin 3和Turbostatin 4。这些化合物是从海洋软体动物Turbo stenogyrus中提取和分离出来的，并且它们的结构已经阐明。这些新的化合物对多种小鼠和人类癌细胞系具有显著的抑制癌细胞生长的活性，因此在治疗各种形式的肿瘤疾病方面将会有用。

  公开号：

  US08053416B2

文献信息

• INDAZOLYL, BENZIMIDAZOLYL, BENZOTRIAZOLYL SUBSTITUTED INDOLINONE DERIVATIVES AS KINASE INHIBITORS USEFUL IN THE TREATMENT OF CANCER
  申请人：Pauls Heinz W.

  公开号：US20110065702A1

  公开（公告）日：2011-03-17

  The present invention is directed to a compound is represented by Structural Formula (A):or a pharmaceutically acceptable salt therof. The present invention is also directed to a pharmaceutical composition comprising a compound represented by Structural Formula (A) described above or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier or diluent. Also disclosed is a method of treating a subject having cancer, wherein the method comprises administering a therapeutically effective amount of a compound represented by Structural Formula (A) described above or a pharmaceutically acceptable salt thereof.

  本发明涉及一种化合物，其结构式表示为(A)或其药学上可接受的盐。本发明还涉及一种药物组合物，包括上述结构式(A)所表示的化合物或其药学上可接受的盐，以及药学上可接受的载体或稀释剂。本发明还揭示了一种治疗患有癌症的受试者的方法，其中该方法包括给予上述结构式(A)所表示的化合物或其药学上可接受的盐的治疗有效量。
• Indazolyl, benzimidazolyl, benzotriazolyl substituted indolinone derivatives as kinase inhibitors useful in the treatment of cancer
  申请人：Pauls Heinz W.

  公开号：US08765748B2

  公开（公告）日：2014-07-01

  The present invention is directed to a compound is represented by Structural Formula (A): or a pharmaceutically acceptable salt thereof. The present invention is also directed to a pharmaceutical composition comprising a compound represented by Structural Formula (A) described above or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier or diluent. Also disclosed is a method of treating a subject having cancer, wherein the method comprises administering a therapeutically effective amount of a compound represented by Structural Formula (A) described above or a pharmaceutically acceptable salt thereof.

  本发明涉及一种由结构式（A）表示的化合物或其药学上可接受的盐。本发明还涉及一种药物组合物，包括上述结构式（A）表示的化合物或其药学上可接受的盐，以及药学上可接受的载体或稀释剂。本发明还揭示了一种治疗癌症患者的方法，其中该方法包括给予上述结构式（A）表示的化合物或其药学上可接受的盐的治疗有效量。
• Method for the production of high concentrations of emulsion polymers
  申请人：Pitney Bowes Inc.

  公开号：US04418183A1

  公开（公告）日：1983-11-29

  A process for the preparation of emulsion polymers having a solid content of about 65% to about 80% is disclosed. The process comprises the step of adding a monomeric mixture to a reaction system maintained at a temperature of from about 60.degree. C. to about 90.degree. C., the monomer addition not exceeding an hourly rate of about one-fourth of the total monomer to be added, the mixture comprising monomers having a particle size of from about 10-100 microns, the system having therein an emulsifier and initiator at the time of the monomeric addition.

  公开了一种制备固体含量约65％至约80％的乳液聚合物的方法。该方法包括将单体混合物添加到维持在约60℃至约90℃的反应系统中，单体添加速率不超过总单体的四分之一每小时，混合物包括粒径约为10-100微米的单体，系统在单体添加时含有乳化剂和引发剂。