2-mercaptomethylglutaric acid | 109333-27-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-mercaptomethylglutaric acid
• 英文别名: 2-(sulfanylmethyl)pentanedioic acid
• CAS: 109333-27-9
• 化学式: C₆H₁₀O₄S
• 分子量: 178.209
• InChiKey: LDFDXRPEWZHIML-UHFFFAOYSA-N

物化性质

• 熔点：
  75 °C(Solv: ethyl acetate (141-78-6); hexane (110-54-3))
• 沸点：
  344.6±32.0 °C(Predicted)
• 密度：
  1.357±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  75.6
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  S-Benzoyl-2-mercaptomethylglutaric Acid 、 2-甲氧基乙胺 生成 2-mercaptomethylglutaric acid
  参考文献：
  名称：

  KALMAN, THOMAS I.

  摘要：

  DOI：

文献信息

• 2-mercaptomethylglutaric acid derivatives
  申请人：The Research Foundation of State University of New York

  公开号：US04927966A1

  公开（公告）日：1990-05-22

  New compounds having utility for enhancing the activity of antifolates are disclosed of the formula: ##STR1## wherein X is selected from hydrogen ##STR2## and R"--; R' is selected from alkyl, alkenyl, alkynyl, substituted and unsubstituted aryl, and substituted and unsubstituted heterocyclic aryl; R" is selected from ##STR3## and R'S; M is selected from OR and secondary amine; and R is selected from hydrogen, alkyl, acyloxymethyl, substituted and unsubstituted aryl, substituted and unsubstituted heterocyclic aryl, amino cation and metal cation.

  本发明揭示了具有增强抗叶酸活性的新化合物的公式：##STR1## 其中X从氢##STR2##和R" - ; R'从烷基，烯基，炔基，取代和未取代芳基，以及取代和未取代杂环芳基中选择；R"从##STR3##和R'S中选择；M从OR和次级胺中选择；R从氢，烷基，酰氧甲基，取代和未取代芳基，取代和未取代杂环芳基，氨基阳离子和金属阳离子中选择。
• Compositions and methods comprising 2-mercaptomethylglutaric acid
  申请人：The Research Foundation of State University of N.Y.

  公开号：US05010103A1

  公开（公告）日：1991-04-23

  New compounds having utility for enhancing the activity of antifolates are disclosed of the formula: ##STR1## wherein X is selected from hydrogen ##STR2## and R" ; R' is selected from alkyl, alkenyl, alkynyl, substituted and unsubstituted aryl, and substituted and unsubstituted heterocyclic aryl; R" is selected from ##STR3## and R'S; M is selected from OR and secondary amine; and R is selected from hydrogen, alkyl, acyloxymethyl, substituted and unsubstituted aryl, substituted and unsubstituted heterocyclic aryl, amino cation and metal cation.

  本发明公开了一种有用于增强抗叶酸活性的新化合物，其化学式为：##STR1## 其中X从氢，##STR2##和R"中选择；R'从烷基，烯基，炔基，取代和未取代芳基，以及取代和未取代杂环芳基中选择；R"从##STR3##和R'S中选择；M从OR和二级胺中选择；而R从氢，烷基，酰氧甲基，取代和未取代芳基，取代和未取代杂环芳基，氨基阳离子和金属阳离子中选择。
• Cast-molding process for producing UV-absorbing contact lenses
  申请人：Novartis AG

  公开号：US11111327B2

  公开（公告）日：2021-09-07

  Described herein is a cast-molding process for producing contact lenses in a relatively-short curing time from a lens-forming composition, which comprises (a) at least one thiol-containing compound or component, (b) at least one metal scavenger, and (c) at least one free radical scavenger and which has a pH of from about 2.5 to about 5. The addition of a chain-transfer agent into a lens-forming composition can reduce not only the curing time of the lens-forming composition but also reduce the elastic modulus of resultant crosslinked materials (e.g., contact lenses) from the lens-forming composition. The lower pH and the addition of metal scavenger and the free radical scavenger into the lens-forming composition can ensure that the lens-forming composition to have a shelf life of at least three days.

  本文描述了一种在相对较短的固化时间内用镜片成型组合物生产隐形眼镜的浇注成型工艺，该组合物包括（a）至少一种含硫醇的化合物或组分，（b）至少一种金属清除剂，以及（c）至少一种自由基清除剂，其 pH 值为约 2.5 至约 5。在镜片成型组合物中加入链转移剂不仅能缩短镜片成型组合物的固化时间，还能降低由镜片成型组合物生成的交联材料（如隐形眼镜）的弹性模量、隐形眼镜）的弹性模量。在镜片成型组合物中降低 pH 值并添加金属清除剂和自由基清除剂，可确保镜片成型组合物的保质期至少为三天。
• Heterocyclisch substituierte Thio(cyclo)alkanpolycarbonsäuren
  申请人：CIBA-GEIGY AG

  公开号：EP0129506B1

  公开（公告）日：1991-03-06
• NAALADASE INHIBITORS USEFUL AS PHARMACEUTICAL COMPOUNDS AND COMPOSITIONS
  申请人：GUILFORD PHARMACEUTICALS INC.

  公开号：EP1093453B1

  公开（公告）日：2005-09-28